This document provides information on peripherally inserted central catheters (PICCs), including guidelines for insertion and care. PICCs are long, thin tubes inserted into a vein in the arm and advanced into the heart to provide intravenous access. They can remain in place for extended periods. Proper care includes hand hygiene, aseptic technique, dressing changes according to guidelines, and flushing/locking to maintain patency and prevent infection. Potential complications include infection, obstruction, phlebitis, malposition, air embolism, and venous spasm. PICCs should not be removed due to risks of air embolism, syncope, venous spasm, and catheter fracture.