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Clinical Presentation
• Acute viral disease endemic in tropical areas
  of Africa and Latin America
• A re-emerging infectious disease for which
  there is no cure or specific treatment
• Preventive vaccine developed in 1937
• Extensive vaccination campaigns ongoing in
  Africa
Transmission



• Yellow fever is an arbovirus – a disease
  transmitted by arthropod vectors
• Mosquito is primary vector
• Mosquito transmits virus primarily between
  monkeys, from monkeys to humans, and from
  person to person
Clinical Periods
• Three distinguishable periods
• Infection: fever, headache, malaise, weakness,
  nausea and vomiting (3-4 days)
• Remission: Symptoms remit before coming back
  with increased intensity
• Intoxication: jaundice, albuminuria,
  cardiovascular instability and hemorrhagic
  manifestations
• 15% of cases progress to intoxication
• Overall 3% case fatality rate

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Clinical presentation

  • 2.
  • 3. • Acute viral disease endemic in tropical areas of Africa and Latin America • A re-emerging infectious disease for which there is no cure or specific treatment • Preventive vaccine developed in 1937 • Extensive vaccination campaigns ongoing in Africa
  • 4. Transmission • Yellow fever is an arbovirus – a disease transmitted by arthropod vectors • Mosquito is primary vector • Mosquito transmits virus primarily between monkeys, from monkeys to humans, and from person to person
  • 5. Clinical Periods • Three distinguishable periods • Infection: fever, headache, malaise, weakness, nausea and vomiting (3-4 days) • Remission: Symptoms remit before coming back with increased intensity • Intoxication: jaundice, albuminuria, cardiovascular instability and hemorrhagic manifestations • 15% of cases progress to intoxication • Overall 3% case fatality rate