This document analyzes the seismic behavior of reinforced concrete (RC) framed buildings with different configurations through computer modeling and simulation. It compares the seismic performance of a bare frame building, an infilled frame building where the spaces between columns and beams are filled with masonry, a building with an open ground floor ("soft story"), and a building with open ground and first floors. The analysis found that the infilled frame performed best, with the highest base shear, natural frequency, and lowest story drift and time period. The bare frame performed worst. The soft story and two-story open configurations performed better than the bare frame but worse than the infilled frame. Infilled frames are therefore most effective at resisting earthquake forces compared to other