Apoptosis extrinsic pathway
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Apoptosis extrinsic pathway
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Apoptosis extrinsic pathway
- 1. Extrinsic Pathway Extrinsic Pathway Death Ligand Death Receptors Caspases Nuclease/Proteas e N
- 3. Apoptotic clearance of cell body - Phagocytosis: is a major mechanism used to remove pathogens and cell debris - Example of Phagocytic Cells: Macrophages (Monocytes) Neutrophils & Eosinophils (Macrophages) - Similarities between Necrosis and apoptosis is that there remnanants are phagocytosed
- 4. Disorders Associated with Dysregulated Apoptosis • Defective apoptosis and increased cell survival • - Mutation in p53 – Cancer – Autoimmune diseases • Increased apoptosis and excessive cell death – Neurodegenerative diseases – Ischemic injury – Death of virus infected cells
- 5. Question and References 1. Is down-regulation of apoptosis associated with cancer? yes or No References https://www.youtube.com/watch?v=TOR7qJsYDKI https://www.khanacademy.org/science/biology/cellular-molecular -biology/stem-cells-and-cancer/e/apoptosis https://drive.google.com/file/d/149Qw1u_Kbs_i5B4v7QuE_kq8ceLS4LZa/view?usp=sharing https://drive.google.com/file/d/17H0I1psQB6WPRwfTMelnSpkj7QIvRMD8/view?usp=sharing https://drive.google.com/file/d/1D4V77LkO5i4jXKXwtmuGKpFR3ARtQh7O/view?usp=sharing
Editor's Notes
- Nuclease will breakdown nuclic acid (DNA) Protease break down proteins - whenn the lamins and actin filaments are cleaved how will the cell survive then they start forming blebs
- How are the intrinsic and extrinsic apoptotic pathways are connected? Activation of caspase 3 via caspase 8 can sometimes be sufficient to induce apoptosis in the extrinsic pathway. Sometimes it isn't though. Caspase 8 is also capable of cleaving and activating BID which induces the intrinsic/mitochondrial pathway (via Bak/Bax), Cytochrome c, apaf1,apoptosome,caspade 9,caspade 3,nuclease
- Defective apoptosis and increased cell survival- imagine viral infection, DNA damage and the cell keep dividing out of hand its leading to - Cancer