SlideShare a Scribd company logo
AMENORRHOEA II
PRIMARY AMENORRHOEA
Amenorrhoea without sec sex characters
• E from ovaries → Breast development
• No breast dev – No E → Amenorrhoea
↓
Hypogonadism
Hypergonadotrophic

Hypogonadotrophic
Hypergonadotrophic Amenorrhoea
• 30% have genetic
abnormalities
• Most common – Turner’s
Syndrome
– 45 XO (accelerated atresia of
follicles)
– Short stature
– Webbed neck
– Shield chest
– Cubitus valgus
– Associated conditions
• Coarctation of aorta
• Horse-shoe kidney
• Autoimmune thyroiditis
Hypergonadotrophic Amenorrhoea
• Pure Gonadal Dysgenesis
– Swyer syndrome – XY female

• Mixed Gonadal Dysgenesis
– Streak gonad & testis

• Enzyme Deficiency (Defect in steroid synthesis)
– Congenital adrenal hyperplasia

• Premature ovarian failure
– Galactosemia, chemotherapy, radiation
Hypogonadotrophic Amenorrhoea
• Physiological / Constitutional Delay
• Kallman’s Syndrome
– Amenorrhoea, sexual infantilism, anosmia

• Inflammation, Trauma, Tumour, Vascular
lesions
• CNS tumour
Diagnosis – History, Clinical, Investigation
Treatment – Replacement therapy, Surgery
PRIMARY AMENORRHOEA
Amenorrhoea with sec sex characters
• Anatomic abnormalities
– Obstruction
– Absence of uterus(M-R-K-H syndrome)
• Assoc with pelvic or horse shoe kidney,
double urinary collecting system, skeletal
abnormalities
PRIMARY AMENORRHOEA
• Androgen Insensitivity
(Testicular feminisation
syn) : problem of
androgen receptors
– Male pseudohermaphrodite
– AMH present : no uterus,
only blind vagina
– Well dev breast with pale
areola & immature nipple
– Scant or absent pubic /
axillary hair
MANAGEMENT
•
•
•
•

Removal of obstruction
Cervix absent or hypoplastic – TAH
Short vagina – Dilatation or reconstruction
Gonad containing Y chromosome –
Gonadectomy
– In androgen insensitivity done after pubertal
development
ASHERMAN’S SYNDROME
Endometrial destruction →Sec amenorrhoea
Cause : Overzealous curettage,
metroplasty, myomectomy, uterine art
embolisation
Diagnosis : HSG, Hysteroscopy
Treatment : D & C, Hysteroscopic
adhesiolysis → Foley’s catheter +
Oestrogen
PITUITARY DISORDERS
• Tumour
– Prolactinoma
– Acromegaly, Cushing’s Disease
– Craniopharyngioma, meningioma, glioma

• Infarction (Sheehan’s Syndrome)
• Inflammation
• Radiological / Surgical ablation
PITUITARY TUMOURS
• Mechanism of action
– Decrease secretion of GnRH
– Mass effect
• Compression of pituitary stalk and prevent delivery
of GnRH

• Empty sella syndrome
• Diagnosis : S/S specific to hormone
Headache, visual symptoms
Imaging
• Treatment : Dopamine agonist, Surgery
HYPOTHALAMIC DISORDER
• Commonest cause of hypogonadotrophic
amenorrhoea
• Diagnosed by exclusion of pituitary lesions
• Low or normal gonadotrophins
• Stress, wt loss, psy disorder, exercise
• Ultimate cause – GnRH suppression
• LPD → anovulation → amenorrhoea
GnRH REGULATION
• ↓ GnRH
– Endogenous opiods, dopamine
– CRH
– GABA
– ↑ Neuropeptide Y
– ↓ Leptin
• ↑ GnRH
– Catecholamines
– Acetylcholine
EFFECT OF BODY FAT
• Critical level of body
– 17 % for initiation of menses
– 22 % for sustaining menses

• “ Fat talks to the brain via leptin”
• “ When available energy is excessively
diverted as in exercise or when insufficient
as with eating disorders, reproduction is
suspended in order to support essential
metabolism for survival”.
ANOREXIA NERVOSA
• Wt loss of 25% or wt below 15% of
normal
• Intense fear of becoming fat
• Altered perception of one’s body
image
• Amenorrhoea
• Food restriction, induced vomitting,
laxative use, intense exercise
• Cold & heat intolerance, lanugo hair,
hypotension, bradycardia, yellow
skin,diabetes insipidus, binge eating
• Can be life threatening →
Psychotherapy

More Related Content

What's hot

Amenorrhea NISHTAR
Amenorrhea NISHTARAmenorrhea NISHTAR
Amenorrhea NISHTAR
MUHAMMAD SAEED
 
amenorrhea
amenorrheaamenorrhea
amenorrhea
Karl Daniel, M.D.
 
Amenorrhea
Amenorrhea Amenorrhea
Amenorrhea
MaHmoud LaZek
 
Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
Tiny SemSem
 
Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
Venkat Ramesh
 
Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
Charu Smita
 
Amenorrhea ppt
Amenorrhea pptAmenorrhea ppt
Amenorrhea ppt
magdy abdel
 
gynaecology.Sec amenorrhea.(dr.hana)
gynaecology.Sec amenorrhea.(dr.hana)gynaecology.Sec amenorrhea.(dr.hana)
gynaecology.Sec amenorrhea.(dr.hana)
student
 
Amenorrhea, Mob: 7289915430, www.drpradeepgarg.com
Amenorrhea,  Mob: 7289915430, www.drpradeepgarg.comAmenorrhea,  Mob: 7289915430, www.drpradeepgarg.com
Amenorrhea, Mob: 7289915430, www.drpradeepgarg.com
Pradeep Garg
 
27.Amenorrhea
27.Amenorrhea27.Amenorrhea
27.Amenorrhea
Deep Deep
 
Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
mohit rulaniya
 
Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
Pallavi Lokhande
 
Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
Rawa Muhsin
 
Menstrual dysfunction
Menstrual dysfunctionMenstrual dysfunction
Menstrual dysfunction
Ruslan Migorianu
 
Amenorrhoea PCOD
Amenorrhoea PCOD Amenorrhoea PCOD
Amenorrhoea PCOD
Salini Mandal
 
Primary amenorrhoea
Primary amenorrhoeaPrimary amenorrhoea
Primary amenorrhoea
drmcbansal
 
Primary amenorrhea
Primary amenorrheaPrimary amenorrhea
Primary amenorrhea
Nahry Omer
 
Management of primary amenorrhoea
Management of primary amenorrhoeaManagement of primary amenorrhoea
Management of primary amenorrhoea
Amrit Neupane
 
Primary amenorrhea and management
Primary amenorrhea and managementPrimary amenorrhea and management
Primary amenorrhea and management
DrSobhan Padhi
 
Amenorrhoea
AmenorrhoeaAmenorrhoea
Amenorrhoea
pushpalatha57
 

What's hot (20)

Amenorrhea NISHTAR
Amenorrhea NISHTARAmenorrhea NISHTAR
Amenorrhea NISHTAR
 
amenorrhea
amenorrheaamenorrhea
amenorrhea
 
Amenorrhea
Amenorrhea Amenorrhea
Amenorrhea
 
Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
 
Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
 
Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
 
Amenorrhea ppt
Amenorrhea pptAmenorrhea ppt
Amenorrhea ppt
 
gynaecology.Sec amenorrhea.(dr.hana)
gynaecology.Sec amenorrhea.(dr.hana)gynaecology.Sec amenorrhea.(dr.hana)
gynaecology.Sec amenorrhea.(dr.hana)
 
Amenorrhea, Mob: 7289915430, www.drpradeepgarg.com
Amenorrhea,  Mob: 7289915430, www.drpradeepgarg.comAmenorrhea,  Mob: 7289915430, www.drpradeepgarg.com
Amenorrhea, Mob: 7289915430, www.drpradeepgarg.com
 
27.Amenorrhea
27.Amenorrhea27.Amenorrhea
27.Amenorrhea
 
Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
 
Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
 
Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
 
Menstrual dysfunction
Menstrual dysfunctionMenstrual dysfunction
Menstrual dysfunction
 
Amenorrhoea PCOD
Amenorrhoea PCOD Amenorrhoea PCOD
Amenorrhoea PCOD
 
Primary amenorrhoea
Primary amenorrhoeaPrimary amenorrhoea
Primary amenorrhoea
 
Primary amenorrhea
Primary amenorrheaPrimary amenorrhea
Primary amenorrhea
 
Management of primary amenorrhoea
Management of primary amenorrhoeaManagement of primary amenorrhoea
Management of primary amenorrhoea
 
Primary amenorrhea and management
Primary amenorrhea and managementPrimary amenorrhea and management
Primary amenorrhea and management
 
Amenorrhoea
AmenorrhoeaAmenorrhoea
Amenorrhoea
 

Viewers also liked

Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
B Johani
 
Amenorrhea made easy slideshare 2015
Amenorrhea made easy   slideshare  2015Amenorrhea made easy   slideshare  2015
Amenorrhea made easy slideshare 2015
Mohammad Emam
 
gynaecology.Primary amenorrhea.(dr.sundus)
gynaecology.Primary amenorrhea.(dr.sundus)gynaecology.Primary amenorrhea.(dr.sundus)
gynaecology.Primary amenorrhea.(dr.sundus)
student
 
Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
Mohd Hanafi
 
Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
raj kumar
 
Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
MaryamAbdulqadir
 
Menstruation and menstrual disorders
Menstruation and menstrual disordersMenstruation and menstrual disorders
Menstruation and menstrual disorders
Wuntima A. Kwame
 
Amenorrea
AmenorreaAmenorrea
MENSTRUAL CYCLE DISORDERS
MENSTRUAL CYCLE DISORDERSMENSTRUAL CYCLE DISORDERS
MENSTRUAL CYCLE DISORDERS
google
 
Medical investigations in gynecological patients
Medical investigations in gynecological patientsMedical investigations in gynecological patients
Medical investigations in gynecological patients
Muni Venkatesh
 
Vulvovaginal infection
Vulvovaginal infectionVulvovaginal infection
Vulvovaginal infection
muhammad al hennawy
 
Clinical Approach to Gynecological Patient (part-1)
Clinical Approach to Gynecological Patient (part-1)Clinical Approach to Gynecological Patient (part-1)
Clinical Approach to Gynecological Patient (part-1)
drmcbansal
 
Practical approach to amenorrhea warda
Practical approach to amenorrhea wardaPractical approach to amenorrhea warda
Practical approach to amenorrhea warda
Osama Warda
 
Amenorrea
AmenorreaAmenorrea
Amenorrea
Susana Gurrola
 
How to approch a case of amenorrhea
How to approch a case of amenorrheaHow to approch a case of amenorrhea
How to approch a case of amenorrhea
Faculty of Medicine,Zagazig University,EGYPT
 
Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
LPDTasTAFE
 
Puberty dr-arshiyasultana-110312042731-phpapp02
Puberty dr-arshiyasultana-110312042731-phpapp02Puberty dr-arshiyasultana-110312042731-phpapp02
Puberty dr-arshiyasultana-110312042731-phpapp02
Asri Purwanti
 
Gyn Infections
Gyn  InfectionsGyn  Infections
Gyn Infections
Miami Dade
 
Menstrual disorders
Menstrual disordersMenstrual disorders
Menstrual disorders
Amir Mahmoud
 
Amenorrea
AmenorreaAmenorrea
Amenorrea
hadoken Boveri
 

Viewers also liked (20)

Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
 
Amenorrhea made easy slideshare 2015
Amenorrhea made easy   slideshare  2015Amenorrhea made easy   slideshare  2015
Amenorrhea made easy slideshare 2015
 
gynaecology.Primary amenorrhea.(dr.sundus)
gynaecology.Primary amenorrhea.(dr.sundus)gynaecology.Primary amenorrhea.(dr.sundus)
gynaecology.Primary amenorrhea.(dr.sundus)
 
Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
 
Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
 
Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
 
Menstruation and menstrual disorders
Menstruation and menstrual disordersMenstruation and menstrual disorders
Menstruation and menstrual disorders
 
Amenorrea
AmenorreaAmenorrea
Amenorrea
 
MENSTRUAL CYCLE DISORDERS
MENSTRUAL CYCLE DISORDERSMENSTRUAL CYCLE DISORDERS
MENSTRUAL CYCLE DISORDERS
 
Medical investigations in gynecological patients
Medical investigations in gynecological patientsMedical investigations in gynecological patients
Medical investigations in gynecological patients
 
Vulvovaginal infection
Vulvovaginal infectionVulvovaginal infection
Vulvovaginal infection
 
Clinical Approach to Gynecological Patient (part-1)
Clinical Approach to Gynecological Patient (part-1)Clinical Approach to Gynecological Patient (part-1)
Clinical Approach to Gynecological Patient (part-1)
 
Practical approach to amenorrhea warda
Practical approach to amenorrhea wardaPractical approach to amenorrhea warda
Practical approach to amenorrhea warda
 
Amenorrea
AmenorreaAmenorrea
Amenorrea
 
How to approch a case of amenorrhea
How to approch a case of amenorrheaHow to approch a case of amenorrhea
How to approch a case of amenorrhea
 
Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
 
Puberty dr-arshiyasultana-110312042731-phpapp02
Puberty dr-arshiyasultana-110312042731-phpapp02Puberty dr-arshiyasultana-110312042731-phpapp02
Puberty dr-arshiyasultana-110312042731-phpapp02
 
Gyn Infections
Gyn  InfectionsGyn  Infections
Gyn Infections
 
Menstrual disorders
Menstrual disordersMenstrual disorders
Menstrual disorders
 
Amenorrea
AmenorreaAmenorrea
Amenorrea
 

Similar to Amenorrhoea Amenorhhea

Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
drnadeemsoomro
 
Anterior pituitary: endocinology, hypopituitarism apoplexy etc..
Anterior pituitary: endocinology, hypopituitarism apoplexy etc.. Anterior pituitary: endocinology, hypopituitarism apoplexy etc..
Anterior pituitary: endocinology, hypopituitarism apoplexy etc..
Vasif Mayan
 
L47 Amenorrhea
L47 AmenorrheaL47 Amenorrhea
Adrenal tumor
Adrenal tumorAdrenal tumor
Adrenal tumor
HappyFridayKnight
 
Approach to pitiutary diseases
Approach to pitiutary diseasesApproach to pitiutary diseases
Approach to pitiutary diseases
DR RML DELHI
 
Pituitary Adenomas-Clinical Neuro-Ophthalmic and Radiological Evaluation.pdf
Pituitary Adenomas-Clinical Neuro-Ophthalmic and Radiological Evaluation.pdfPituitary Adenomas-Clinical Neuro-Ophthalmic and Radiological Evaluation.pdf
Pituitary Adenomas-Clinical Neuro-Ophthalmic and Radiological Evaluation.pdf
FrankyQ2
 
Amenorrhea.warda
Amenorrhea.wardaAmenorrhea.warda
Amenorrhea.warda
Osama Warda
 
amenorrhea
amenorrheaamenorrhea
amenorrhea
PRIYANKAMARU6
 
Hypopituitarism
HypopituitarismHypopituitarism
Hypopituitarism
Shivshankar Badole
 
Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
Poly Begum
 
25 endocrine
25 endocrine25 endocrine
25 endocrine
Reach Na
 
Amenorrhea definition causes and mangement.pptx
Amenorrhea definition  causes and mangement.pptxAmenorrhea definition  causes and mangement.pptx
Amenorrhea definition causes and mangement.pptx
MohamedHussien128965
 
ADRENAL DISORDER.pptx
ADRENAL DISORDER.pptxADRENAL DISORDER.pptx
ADRENAL DISORDER.pptx
AkhilAnto9
 
Endo Reproduction
Endo ReproductionEndo Reproduction
Endo Reproduction
Miami Dade
 
L45 Genital tract development and Puberty & their disorders
L45 Genital tract development and Puberty & their disordersL45 Genital tract development and Puberty & their disorders
L45 Genital tract development and Puberty & their disorders
Public Health & Medical Academy
 
Gonadal horomone disorders
Gonadal horomone disorders Gonadal horomone disorders
Gonadal horomone disorders
binaya tamang
 
Menopause
MenopauseMenopause
Menopause
ABParbadiya
 
HYPOPITUITARISM.pptx
HYPOPITUITARISM.pptxHYPOPITUITARISM.pptx
HYPOPITUITARISM.pptx
GENERALMEDICEGDMC
 
HYPOPITUITARISM1.pptx
HYPOPITUITARISM1.pptxHYPOPITUITARISM1.pptx
HYPOPITUITARISM1.pptx
AnupamAnand60
 
Endocrine DOs.pptx
Endocrine DOs.pptxEndocrine DOs.pptx
Endocrine DOs.pptx
MohammedAbdela7
 

Similar to Amenorrhoea Amenorhhea (20)

Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
 
Anterior pituitary: endocinology, hypopituitarism apoplexy etc..
Anterior pituitary: endocinology, hypopituitarism apoplexy etc.. Anterior pituitary: endocinology, hypopituitarism apoplexy etc..
Anterior pituitary: endocinology, hypopituitarism apoplexy etc..
 
L47 Amenorrhea
L47 AmenorrheaL47 Amenorrhea
L47 Amenorrhea
 
Adrenal tumor
Adrenal tumorAdrenal tumor
Adrenal tumor
 
Approach to pitiutary diseases
Approach to pitiutary diseasesApproach to pitiutary diseases
Approach to pitiutary diseases
 
Pituitary Adenomas-Clinical Neuro-Ophthalmic and Radiological Evaluation.pdf
Pituitary Adenomas-Clinical Neuro-Ophthalmic and Radiological Evaluation.pdfPituitary Adenomas-Clinical Neuro-Ophthalmic and Radiological Evaluation.pdf
Pituitary Adenomas-Clinical Neuro-Ophthalmic and Radiological Evaluation.pdf
 
Amenorrhea.warda
Amenorrhea.wardaAmenorrhea.warda
Amenorrhea.warda
 
amenorrhea
amenorrheaamenorrhea
amenorrhea
 
Hypopituitarism
HypopituitarismHypopituitarism
Hypopituitarism
 
Amenorrhea
AmenorrheaAmenorrhea
Amenorrhea
 
25 endocrine
25 endocrine25 endocrine
25 endocrine
 
Amenorrhea definition causes and mangement.pptx
Amenorrhea definition  causes and mangement.pptxAmenorrhea definition  causes and mangement.pptx
Amenorrhea definition causes and mangement.pptx
 
ADRENAL DISORDER.pptx
ADRENAL DISORDER.pptxADRENAL DISORDER.pptx
ADRENAL DISORDER.pptx
 
Endo Reproduction
Endo ReproductionEndo Reproduction
Endo Reproduction
 
L45 Genital tract development and Puberty & their disorders
L45 Genital tract development and Puberty & their disordersL45 Genital tract development and Puberty & their disorders
L45 Genital tract development and Puberty & their disorders
 
Gonadal horomone disorders
Gonadal horomone disorders Gonadal horomone disorders
Gonadal horomone disorders
 
Menopause
MenopauseMenopause
Menopause
 
HYPOPITUITARISM.pptx
HYPOPITUITARISM.pptxHYPOPITUITARISM.pptx
HYPOPITUITARISM.pptx
 
HYPOPITUITARISM1.pptx
HYPOPITUITARISM1.pptxHYPOPITUITARISM1.pptx
HYPOPITUITARISM1.pptx
 
Endocrine DOs.pptx
Endocrine DOs.pptxEndocrine DOs.pptx
Endocrine DOs.pptx
 

More from Jitendra Ingole

Hepatitis acute
Hepatitis acute Hepatitis acute
Hepatitis acute
Jitendra Ingole
 
Dysfunctional Uterine Bleeding (DUB)
Dysfunctional Uterine Bleeding (DUB)Dysfunctional Uterine Bleeding (DUB)
Dysfunctional Uterine Bleeding (DUB)
Jitendra Ingole
 
Doctor as detective
Doctor as detectiveDoctor as detective
Doctor as detective
Jitendra Ingole
 
Collection of blood for investigation met microteaching ppt
Collection of blood for investigation met microteaching pptCollection of blood for investigation met microteaching ppt
Collection of blood for investigation met microteaching ppt
Jitendra Ingole
 
Diabetes & high cholesterol _ Dr Ingole
Diabetes & high cholesterol _ Dr IngoleDiabetes & high cholesterol _ Dr Ingole
Diabetes & high cholesterol _ Dr Ingole
Jitendra Ingole
 
Dr Ingole_hypertension treatment concepts ,.,
Dr Ingole_hypertension treatment concepts ,.,Dr Ingole_hypertension treatment concepts ,.,
Dr Ingole_hypertension treatment concepts ,.,
Jitendra Ingole
 
Epilepsy and pregnancy ..,,
Epilepsy and pregnancy ..,, Epilepsy and pregnancy ..,,
Epilepsy and pregnancy ..,,
Jitendra Ingole
 
Subtle signs of myocardial ischaemia on ecg
Subtle signs of myocardial ischaemia on ecgSubtle signs of myocardial ischaemia on ecg
Subtle signs of myocardial ischaemia on ecg
Jitendra Ingole
 
COPD Asthma Workshop
COPD Asthma Workshop COPD Asthma Workshop
COPD Asthma Workshop
Jitendra Ingole
 
Diplopia
DiplopiaDiplopia
Diplopia
Jitendra Ingole
 
Pcos
PcosPcos
Iugr (1)
Iugr (1)Iugr (1)
Iugr (1)
Jitendra Ingole
 
Uterine anomalies
Uterine anomaliesUterine anomalies
Uterine anomalies
Jitendra Ingole
 
Caesarean section
Caesarean sectionCaesarean section
Caesarean section
Jitendra Ingole
 
Bleeding in early pregnancy
Bleeding in early pregnancyBleeding in early pregnancy
Bleeding in early pregnancy
Jitendra Ingole
 
Abortion
AbortionAbortion
Abortion
Jitendra Ingole
 
Abnormal cytology & histology of cervix _ Histopathology
Abnormal cytology & histology of cervix _ Histopathology Abnormal cytology & histology of cervix _ Histopathology
Abnormal cytology & histology of cervix _ Histopathology
Jitendra Ingole
 
Water and you-manthena raju
Water and you-manthena rajuWater and you-manthena raju
Water and you-manthena raju
Jitendra Ingole
 
Doctor as detective new
Doctor as detective newDoctor as detective new
Doctor as detective new
Jitendra Ingole
 
Manthena raju a proven cure diabetes
  Manthena raju  a proven cure diabetes  Manthena raju  a proven cure diabetes
Manthena raju a proven cure diabetes
Jitendra Ingole
 

More from Jitendra Ingole (20)

Hepatitis acute
Hepatitis acute Hepatitis acute
Hepatitis acute
 
Dysfunctional Uterine Bleeding (DUB)
Dysfunctional Uterine Bleeding (DUB)Dysfunctional Uterine Bleeding (DUB)
Dysfunctional Uterine Bleeding (DUB)
 
Doctor as detective
Doctor as detectiveDoctor as detective
Doctor as detective
 
Collection of blood for investigation met microteaching ppt
Collection of blood for investigation met microteaching pptCollection of blood for investigation met microteaching ppt
Collection of blood for investigation met microteaching ppt
 
Diabetes & high cholesterol _ Dr Ingole
Diabetes & high cholesterol _ Dr IngoleDiabetes & high cholesterol _ Dr Ingole
Diabetes & high cholesterol _ Dr Ingole
 
Dr Ingole_hypertension treatment concepts ,.,
Dr Ingole_hypertension treatment concepts ,.,Dr Ingole_hypertension treatment concepts ,.,
Dr Ingole_hypertension treatment concepts ,.,
 
Epilepsy and pregnancy ..,,
Epilepsy and pregnancy ..,, Epilepsy and pregnancy ..,,
Epilepsy and pregnancy ..,,
 
Subtle signs of myocardial ischaemia on ecg
Subtle signs of myocardial ischaemia on ecgSubtle signs of myocardial ischaemia on ecg
Subtle signs of myocardial ischaemia on ecg
 
COPD Asthma Workshop
COPD Asthma Workshop COPD Asthma Workshop
COPD Asthma Workshop
 
Diplopia
DiplopiaDiplopia
Diplopia
 
Pcos
PcosPcos
Pcos
 
Iugr (1)
Iugr (1)Iugr (1)
Iugr (1)
 
Uterine anomalies
Uterine anomaliesUterine anomalies
Uterine anomalies
 
Caesarean section
Caesarean sectionCaesarean section
Caesarean section
 
Bleeding in early pregnancy
Bleeding in early pregnancyBleeding in early pregnancy
Bleeding in early pregnancy
 
Abortion
AbortionAbortion
Abortion
 
Abnormal cytology & histology of cervix _ Histopathology
Abnormal cytology & histology of cervix _ Histopathology Abnormal cytology & histology of cervix _ Histopathology
Abnormal cytology & histology of cervix _ Histopathology
 
Water and you-manthena raju
Water and you-manthena rajuWater and you-manthena raju
Water and you-manthena raju
 
Doctor as detective new
Doctor as detective newDoctor as detective new
Doctor as detective new
 
Manthena raju a proven cure diabetes
  Manthena raju  a proven cure diabetes  Manthena raju  a proven cure diabetes
Manthena raju a proven cure diabetes
 

Recently uploaded

biomechanics of running. Dr.dhwani.pptx
biomechanics of running.   Dr.dhwani.pptxbiomechanics of running.   Dr.dhwani.pptx
biomechanics of running. Dr.dhwani.pptx
Dr. Dhwani kawedia
 
Introduction to British pharmacopeia.pptx
Introduction to British pharmacopeia.pptxIntroduction to British pharmacopeia.pptx
Introduction to British pharmacopeia.pptx
taiba qazi
 
Top Travel Vaccinations in Manchester
Top Travel Vaccinations in ManchesterTop Travel Vaccinations in Manchester
Top Travel Vaccinations in Manchester
NX Healthcare
 
5 Effective Homeopathic Medicines for Irregular Periods
5 Effective Homeopathic Medicines for Irregular Periods5 Effective Homeopathic Medicines for Irregular Periods
5 Effective Homeopathic Medicines for Irregular Periods
Dr. Deepika's Homeopathy - Gaur City
 
Skin Diseases That Happen During Summer.
 Skin Diseases That Happen During Summer. Skin Diseases That Happen During Summer.
Skin Diseases That Happen During Summer.
Gokuldas Hospital
 
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7
shruti jagirdar
 
Local anesthetics 2024/ Medicinal Chemistry pdf
Local anesthetics 2024/ Medicinal Chemistry pdfLocal anesthetics 2024/ Medicinal Chemistry pdf
Local anesthetics 2024/ Medicinal Chemistry pdf
NarminHamaaminHussen
 
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.GawadHemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
NephroTube - Dr.Gawad
 
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdf
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdfOsvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdf
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdf
Osvaldo Bernardo Muchanga
 
June 2024 Oncology Cartoons By Dr Kanhu Charan Patro
June 2024 Oncology Cartoons By Dr Kanhu Charan PatroJune 2024 Oncology Cartoons By Dr Kanhu Charan Patro
June 2024 Oncology Cartoons By Dr Kanhu Charan Patro
Kanhu Charan
 
“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...
“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...
“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...
Université de Montréal
 
What are the different types of Dental implants.
What are the different types of Dental implants.What are the different types of Dental implants.
What are the different types of Dental implants.
Gokuldas Hospital
 
Giloy in Ayurveda - Classical Categorization and Synonyms
Giloy in Ayurveda - Classical Categorization and SynonymsGiloy in Ayurveda - Classical Categorization and Synonyms
Giloy in Ayurveda - Classical Categorization and Synonyms
Planet Ayurveda
 
Debunking Nutrition Myths: Separating Fact from Fiction"
Debunking Nutrition Myths: Separating Fact from Fiction"Debunking Nutrition Myths: Separating Fact from Fiction"
Debunking Nutrition Myths: Separating Fact from Fiction"
AlexandraDiaz101
 
pharmacology for dummies free pdf download.pdf
pharmacology for dummies free pdf download.pdfpharmacology for dummies free pdf download.pdf
pharmacology for dummies free pdf download.pdf
KerlynIgnacio
 
Ophthalmic drugs latest. Xxxxxxzxxxxxx.pdf
Ophthalmic drugs latest. Xxxxxxzxxxxxx.pdfOphthalmic drugs latest. Xxxxxxzxxxxxx.pdf
Ophthalmic drugs latest. Xxxxxxzxxxxxx.pdf
MuhammadMuneer49
 
Medical Quiz ( Online Quiz for API Meet 2024 ).pdf
Medical Quiz ( Online Quiz for API Meet 2024 ).pdfMedical Quiz ( Online Quiz for API Meet 2024 ).pdf
Medical Quiz ( Online Quiz for API Meet 2024 ).pdf
Jim Jacob Roy
 
Tele Optometry (kunj'sppt) / Basics of tele optometry.
Tele Optometry (kunj'sppt) / Basics of tele optometry.Tele Optometry (kunj'sppt) / Basics of tele optometry.
Tele Optometry (kunj'sppt) / Basics of tele optometry.
Kunj Vihari
 
Travel Clinic Cardiff: Health Advice for International Travelers
Travel Clinic Cardiff: Health Advice for International TravelersTravel Clinic Cardiff: Health Advice for International Travelers
Travel Clinic Cardiff: Health Advice for International Travelers
NX Healthcare
 
Cervical Disc Arthroplasty ORSI 2024.pptx
Cervical Disc Arthroplasty ORSI 2024.pptxCervical Disc Arthroplasty ORSI 2024.pptx
Cervical Disc Arthroplasty ORSI 2024.pptx
LEFLOT Jean-Louis
 

Recently uploaded (20)

biomechanics of running. Dr.dhwani.pptx
biomechanics of running.   Dr.dhwani.pptxbiomechanics of running.   Dr.dhwani.pptx
biomechanics of running. Dr.dhwani.pptx
 
Introduction to British pharmacopeia.pptx
Introduction to British pharmacopeia.pptxIntroduction to British pharmacopeia.pptx
Introduction to British pharmacopeia.pptx
 
Top Travel Vaccinations in Manchester
Top Travel Vaccinations in ManchesterTop Travel Vaccinations in Manchester
Top Travel Vaccinations in Manchester
 
5 Effective Homeopathic Medicines for Irregular Periods
5 Effective Homeopathic Medicines for Irregular Periods5 Effective Homeopathic Medicines for Irregular Periods
5 Effective Homeopathic Medicines for Irregular Periods
 
Skin Diseases That Happen During Summer.
 Skin Diseases That Happen During Summer. Skin Diseases That Happen During Summer.
Skin Diseases That Happen During Summer.
 
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7
 
Local anesthetics 2024/ Medicinal Chemistry pdf
Local anesthetics 2024/ Medicinal Chemistry pdfLocal anesthetics 2024/ Medicinal Chemistry pdf
Local anesthetics 2024/ Medicinal Chemistry pdf
 
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.GawadHemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
 
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdf
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdfOsvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdf
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdf
 
June 2024 Oncology Cartoons By Dr Kanhu Charan Patro
June 2024 Oncology Cartoons By Dr Kanhu Charan PatroJune 2024 Oncology Cartoons By Dr Kanhu Charan Patro
June 2024 Oncology Cartoons By Dr Kanhu Charan Patro
 
“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...
“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...
“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...
 
What are the different types of Dental implants.
What are the different types of Dental implants.What are the different types of Dental implants.
What are the different types of Dental implants.
 
Giloy in Ayurveda - Classical Categorization and Synonyms
Giloy in Ayurveda - Classical Categorization and SynonymsGiloy in Ayurveda - Classical Categorization and Synonyms
Giloy in Ayurveda - Classical Categorization and Synonyms
 
Debunking Nutrition Myths: Separating Fact from Fiction"
Debunking Nutrition Myths: Separating Fact from Fiction"Debunking Nutrition Myths: Separating Fact from Fiction"
Debunking Nutrition Myths: Separating Fact from Fiction"
 
pharmacology for dummies free pdf download.pdf
pharmacology for dummies free pdf download.pdfpharmacology for dummies free pdf download.pdf
pharmacology for dummies free pdf download.pdf
 
Ophthalmic drugs latest. Xxxxxxzxxxxxx.pdf
Ophthalmic drugs latest. Xxxxxxzxxxxxx.pdfOphthalmic drugs latest. Xxxxxxzxxxxxx.pdf
Ophthalmic drugs latest. Xxxxxxzxxxxxx.pdf
 
Medical Quiz ( Online Quiz for API Meet 2024 ).pdf
Medical Quiz ( Online Quiz for API Meet 2024 ).pdfMedical Quiz ( Online Quiz for API Meet 2024 ).pdf
Medical Quiz ( Online Quiz for API Meet 2024 ).pdf
 
Tele Optometry (kunj'sppt) / Basics of tele optometry.
Tele Optometry (kunj'sppt) / Basics of tele optometry.Tele Optometry (kunj'sppt) / Basics of tele optometry.
Tele Optometry (kunj'sppt) / Basics of tele optometry.
 
Travel Clinic Cardiff: Health Advice for International Travelers
Travel Clinic Cardiff: Health Advice for International TravelersTravel Clinic Cardiff: Health Advice for International Travelers
Travel Clinic Cardiff: Health Advice for International Travelers
 
Cervical Disc Arthroplasty ORSI 2024.pptx
Cervical Disc Arthroplasty ORSI 2024.pptxCervical Disc Arthroplasty ORSI 2024.pptx
Cervical Disc Arthroplasty ORSI 2024.pptx
 

Amenorrhoea Amenorhhea

  • 2. PRIMARY AMENORRHOEA Amenorrhoea without sec sex characters • E from ovaries → Breast development • No breast dev – No E → Amenorrhoea ↓ Hypogonadism Hypergonadotrophic Hypogonadotrophic
  • 3. Hypergonadotrophic Amenorrhoea • 30% have genetic abnormalities • Most common – Turner’s Syndrome – 45 XO (accelerated atresia of follicles) – Short stature – Webbed neck – Shield chest – Cubitus valgus – Associated conditions • Coarctation of aorta • Horse-shoe kidney • Autoimmune thyroiditis
  • 4. Hypergonadotrophic Amenorrhoea • Pure Gonadal Dysgenesis – Swyer syndrome – XY female • Mixed Gonadal Dysgenesis – Streak gonad & testis • Enzyme Deficiency (Defect in steroid synthesis) – Congenital adrenal hyperplasia • Premature ovarian failure – Galactosemia, chemotherapy, radiation
  • 5. Hypogonadotrophic Amenorrhoea • Physiological / Constitutional Delay • Kallman’s Syndrome – Amenorrhoea, sexual infantilism, anosmia • Inflammation, Trauma, Tumour, Vascular lesions • CNS tumour Diagnosis – History, Clinical, Investigation Treatment – Replacement therapy, Surgery
  • 6. PRIMARY AMENORRHOEA Amenorrhoea with sec sex characters • Anatomic abnormalities – Obstruction – Absence of uterus(M-R-K-H syndrome) • Assoc with pelvic or horse shoe kidney, double urinary collecting system, skeletal abnormalities
  • 7. PRIMARY AMENORRHOEA • Androgen Insensitivity (Testicular feminisation syn) : problem of androgen receptors – Male pseudohermaphrodite – AMH present : no uterus, only blind vagina – Well dev breast with pale areola & immature nipple – Scant or absent pubic / axillary hair
  • 8. MANAGEMENT • • • • Removal of obstruction Cervix absent or hypoplastic – TAH Short vagina – Dilatation or reconstruction Gonad containing Y chromosome – Gonadectomy – In androgen insensitivity done after pubertal development
  • 9. ASHERMAN’S SYNDROME Endometrial destruction →Sec amenorrhoea Cause : Overzealous curettage, metroplasty, myomectomy, uterine art embolisation Diagnosis : HSG, Hysteroscopy Treatment : D & C, Hysteroscopic adhesiolysis → Foley’s catheter + Oestrogen
  • 10. PITUITARY DISORDERS • Tumour – Prolactinoma – Acromegaly, Cushing’s Disease – Craniopharyngioma, meningioma, glioma • Infarction (Sheehan’s Syndrome) • Inflammation • Radiological / Surgical ablation
  • 11. PITUITARY TUMOURS • Mechanism of action – Decrease secretion of GnRH – Mass effect • Compression of pituitary stalk and prevent delivery of GnRH • Empty sella syndrome • Diagnosis : S/S specific to hormone Headache, visual symptoms Imaging • Treatment : Dopamine agonist, Surgery
  • 12. HYPOTHALAMIC DISORDER • Commonest cause of hypogonadotrophic amenorrhoea • Diagnosed by exclusion of pituitary lesions • Low or normal gonadotrophins • Stress, wt loss, psy disorder, exercise • Ultimate cause – GnRH suppression • LPD → anovulation → amenorrhoea
  • 13. GnRH REGULATION • ↓ GnRH – Endogenous opiods, dopamine – CRH – GABA – ↑ Neuropeptide Y – ↓ Leptin • ↑ GnRH – Catecholamines – Acetylcholine
  • 14. EFFECT OF BODY FAT • Critical level of body – 17 % for initiation of menses – 22 % for sustaining menses • “ Fat talks to the brain via leptin” • “ When available energy is excessively diverted as in exercise or when insufficient as with eating disorders, reproduction is suspended in order to support essential metabolism for survival”.
  • 15. ANOREXIA NERVOSA • Wt loss of 25% or wt below 15% of normal • Intense fear of becoming fat • Altered perception of one’s body image • Amenorrhoea • Food restriction, induced vomitting, laxative use, intense exercise • Cold & heat intolerance, lanugo hair, hypotension, bradycardia, yellow skin,diabetes insipidus, binge eating • Can be life threatening → Psychotherapy