1. Chiral Analysis and Separation
Chirality exists in many substances in nature. For example, naturally
occurring sugars as well as nucleic acids, starch, cellulose, proteins,
and amino acids are all chiral compounds. Chiral analysis and
separation refers to the analysis of chiral molecules that are mixed
together by a range of modern analytical devices and methods,
including high performance liquid chromatography (HPLC), gas
chromatography (GC), supercritical fluid chromatography (SFC),
capillary electrophoresis (CE), sensor methods, and spectrometry.
Application of Chiral Analysis and Separation
The significance of chiral separation is its role in chemical drugs that
are used for human disease treatment and in fine chemicals such as
insecticides, fungicides, insect sex pheromones, plant growth
regulators, food additives, spices, etc. One part has one to two chiral
centers. Many studies have shown that single-configuration chiral
molecule is usually a stereoisomer that has utility value, but its mirror
image molecule is useless or even harmful. Therefore, it is necessary
to study the physicochemical properties of chiral substances that are
enantiomers to each other, and obtain a single chiral enantiomer that
is beneficial to the human body and the environment.
BOC Sciences has advanced equipment and first-class
technology to provide chiral analysis and separation services.
Technologies for Chiral Analysis and Separation
Chromatographic techniques commonly used for chiral separations
include: TLC, GC, CE, SFC, and HPLC. Chromatography has become
the main tool for current chiral analysis and separation. Taking HPLC
as an example, it has a wide range of applications and strong
separation capability, and it has become one of the preferred
technology platforms for the separation of chiral compounds. SFC,
another example, is a new chromatographic technique. It can
2. separate and analyze objects that gas and liquid chromatography
cannot.
Enantiomer identification (HPLC/SCF)
The method for identifying compounds by HPLC and SFC is basically
the same, and it is to determine what each chromatogram peak
represents, and thus determine the composition of the sample mixture
made up of these components.
Enantiomeric purification (HPLC/SCF)
The method for the purification of enantiomers by high performance
liquid chromatography (HPLC) and supercritical fluid chromatography
(SFC) is generally referred to as the continuous adsorption and
desorption of compounds between the stationary phase (the column)
and the mobile phase so that different compounds can be separated.
Because different compounds have different forces between the two
(stationary phase and mobile phase). Some chiral substances and
spatial isomers have almost the same polarity, so they are difficult to
separate. Therefore, special chiral columns are needed to separate
them for purify.
Our Advantages
Ship compounds in milligrams to kilograms. Typically, smaller
samples are processed in a few days, and the process we develop
can be extended as your program needs to be upgraded.
A chromatographic solution that suits your schedule and budget.
Normal phase or SFC for rapid analysis and process monitoring.
Validation-prepare for bulk publishing and stability.
Inverse biological analysis.
We provide regulatory-driven analysis to support your regulatory
plans, such as new chemical notification research or drug
development requirements. BOC Sciences has state-of-the-art HPLC,
3. GC, CE, and SFC equipment, as well as a dedicated team of experts
who can customize the chiral analysis and separation services for
you.
