Mr. Jones is admitted to the hospital with an exacerbation of heart failure. He has +3 peripheral edema of the lower extremities. What are the possible causes of his peripheral edema? Solution Peripheral edema is edema in tissue perfused by the peripheral vascular system usually in the lower limbs. In the most dependent parts of the body, it may be called dependent edema. The condition is commonly associated with aging, but can be caused by many other conditions including congestive heart failure trauma alcohlism altitude sickness pregnancy hypertension sickle cell anemia compromised lymphatic system or merely long periods of time sitting or standing without moving. Some medicines may also cause or worsen the condition. Successful treatment depends on control of the underlying cause. Service swelling can cause permanent damage to nerves resulting in peripheral neuropathy. Many cases from temporary or minor cause resolve on their on, with no lasting damage..