What is the structural difference between the sugar found in RNA and the sugar found in DNA? A. The presence of a 3’ hydroxyl B. The presence of a 2’ hydroxyl C. The presence of a 5’ hydroxyl D. The presence of a ring oxygen Solution ANS: B. The presence of a 2’ hydroxyl. Explanation: Both DNA and RNA nucleotides are made up with a Nitrogenous base, 5-carbon sugar and phosphate group. The sugar molecule in ribonucleotides is Beta- D- Ribofuranose (Ribo furanose), where as in de oxy ribonucleotides it is 2-De oxy Beta- D- Ribofuranose. RNA contains oxygen molecule on second position of its Ribose sugar. In DNA it is absent; due to this nature DNA is more chemically stable when comparing with RNA..