Corticosteroid induced psychosis: 3-4 days after initial therapy symptoms appear. Last days to 3wks or more. Abnormalities of the hypothalamo-pituitary-adrenal axis can result in mood 40mg or more increases risk.
A true vasculitic process occurs much less often.Autoantibodies for SLE: ANA, Anti-dsDNA, Anti-Sm, Anti-SSA or B Anti-histone for drug induced Lupus procainamide and hydralazine
Neuropsychiatric manifestations of systematic lupus
Systemic Lupus is an autoimmune disorder
affecting multiple organs.
Inflammation and tissue damage occurs due to
the body attacking its own cells and tissues.
It is a type III reaction in which antibody-
immune complexes precipitate and cause a
further immune response.
the production of unusual antibodies in the
Eight times more common in women than men.
About 10% of people with lupus isolated to the
skin will develop the systemic form of lupus
Acute confusional state
Depression, anxiety, obsessive-compulsive
Hallucinosis, and schizophrenia-like psychosis.
Mechanism is still unknown but some theories
are talked about are:
The presence of a vasculopathic state
(abnormal vessel walls without inflammatory
cell infiltrates) of small vessels which alters
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