How did the discovery of three categories of petite mutations in yeast lead researchers to postulate extranuclear inheritance of colony size? Whereas segregational petites exhibited Mendelian inheritance, both neutral and suppressive petites followed non-Mendelian patterns that were consistent with the involvement of nuclear inheritance. Whereas segregational petites exhibited Mendelian inheritance, both neutral and suppressive petites followed non-Mendelian patterns that were consistent with the involvement of an extranuclear agent. Whereas suppressive petites exhibited Mendelian inheritance, both neutral and segregational petites followed non-Mendelian patterns that were consistent with the involvement of an extranuclear agent. Whereas suppressive petites exhibited Mendelian inheritance, both neutral and segregational petites followed non-Mendelian patterns that were consistent with the involvement of nuclear inheritance. Solution Whereas segregational petites exhibited Mendelian inheritance, both neutral and suppressive petites followed non-Mendelian patterns that were consistent with the involvement of nuclear inheritance. --------- Extra nuclear inheritance means, inheritance patterns involving genetic material outside the nucleus, here the genome is residing in mitochondria or chloroplast. The segregation petite followed Mendelian type of inheritance (wild type and segregation when mated, segregated in 1:1 ratio), and if any mutation has occurred in the cell nucleus, it affected the protein production needed for mitochondrial function. Where as neutral petites, they did not have most of their mt DNA and but then it was mated with wild type resulted in all wild type 4: neutral 0. So, these are not following Mendelian type of inheritance. In case, of suppressive petites, when suppressive mutants mated with wild type resulted in All wild type 4: 0 all petite. So they are also not following Mendelian inheritance..