Dengue fever, a mosquito borne viral disease is caused by 1 of 4 closely related serotypes of dengue virus. These serotypes are antigenically distinct namely DENV-1 through DEN-4. Infection with any one type confers a very short period of partial heterotypic immunity but lifelong homotypic immunity. During an epidemic several serotypes can be in circulation. In severe infection, lactic acidosis, hypoglycaemia, hypocalcemia and eventual multiple organ failure occurs. Viral damage and subsequent tissue inflammation culminates myocarditis, encephalopathy and liver necrosis. Solution Dengue fever, a mosquito borne viral disease is caused by 1 of 4 closely related serotypes of dengue virus. These serotypes are antigenically distinct namely DENV-1 through DEN-4. Infection with any one type confers a very short period of partial heterotypic immunity but lifelong homotypic immunity. During an epidemic several serotypes can be in circulation. In severe infection, lactic acidosis, hypoglycaemia, hypocalcemia and eventual multiple organ failure occurs. Viral damage and subsequent tissue inflammation culminates myocarditis, encephalopathy and liver necrosis..