Biochemistry for explanation please contact me.. yashodhankunjir.01@gmail.com

1. DIABETES MELLITUS
TYPE 2
YASHODHAN SUNIL KUNJIR
GROUP -1

2. Introduction
• Chronic metabolic disorder characterized by persistent
hyperglycaemia, insulin resistance, and relative insulin
deficiency.
• It is also known as Lifestyle DM & Non-insulin
dependent DM

3. Etiolog
y

4. Etiolog
y
• In T2DM, the response to insulin
is diminished, and this is defined
as insulin resistance
• T2DM is most commonly seen in
persons older than 45 years.
Still, it is increasingly seen in
children, adolescents, and
younger adults due to rising levels
of obesity, physical inactivity, and
energy-dense diets.

5. Pathophysiolog
y
• Type 2 DM is
characterized by
insulin insensitivity
as a result of
insulin resistance,
declining insulin
production, and
eventual pancreatic
beta-cell failure.

6. Insulin Resistance

7. Symptoms

8. Diagnosis
• Diabetes can be diagnosed either by the
hemoglobin A1C criteria or plasma glucose
concentration (fasting or 2-hour plasma
glucose).
• OGTT

9. Pharma Treatment
• Metformin (Fortamet, Glumetza,
others)
• Biguanides
• Sulfonylureas
• Meglitinides
• Thiazolidinediones
• Alpha-Glucosidase Inhibitors
• Incretin-Based Therapies
• Dipeptidyl-Peptidase IV Inhibitors
• Bromocriptine

10. Conclusion
• Type 2 DM is a metabolic disease that can be prevented
through lifestyle modification, diet control, and control of
overweight and obesity
• Education of the populace is still key to the control of this
emerging epidemic.
• Novel drugs are being developed, yet no cure is available in
sight for the disease, despite new insight into the
pathophysiology of the disease.
• Management should be tailored to improve the quality of life
of individuals with type 2 DM.

11. Reference
• https://www.ncbi.nlm.nih.gov/pmc/
articles/PMC3464757/
• https://www.ncbi.nlm.nih.gov/books/
NBK513253/
• https://emedicine.medscape.com/
article/117853-overview
• https://www.mayoclinic.org/diseases-
conditions/type-2-diabetes/symptoms-
causes/syc-20351193

12. THANK YOU 😊