Adrian Hernandez, MD, MHS, prepared heart failure infographics for this CME activity titled "Recognizing and Treating Iron Deficiency in Patients With Heart Failure: Achieving Better Outcomes and Quality of Life." For the full presentation, monograph, complete CME information, and to apply for credit, please visit us at http://bit.ly/307QteC. CME credit will be available until June 13, 2020.

1. ACC/AHA/HFSA (2017)2
ESC (2016)3
AND
Ferritin <100 mcg/L
Ferritin 100-299 mcg/L
if transferrin saturation <20%
ORHFrEF
and
symptoms
COR IIa LOE A
NYHA
II-III
AND
Ferritin <100 ng/mL
Ferritin 100-300 ng/mL
if transferrin saturation <20%
OR
COR IIb LOE B-R
No iron deficiency / no anemia
No iron deficiency / anemia
Iron deficiency / no anemia
Iron deficiency / anemia
Frequency of Iron Deficiency
in Patients With HF, %
Prevalence1
NYHA I
n = 121
NYHA II
n = 577
NYHA III
n = 712
NYHA IV
n = 96
Pathophysiology4
Guidelines
Iron Deficiency
Inflammation
↓ Transferrin
HFrEF
Signs and Symptoms
IV iron may alleviate worsening HF
symptoms and reduce hospitalizations
Recognizing and Treating Iron Deficiency in Patients With Heart Failure:
Achieving Better Outcomes and Quality of Life
Full references, accreditation, and disclosure information available at PeerView.com/FCG930
Recognizing Iron Deficiency in Patients With Heart Failure: Prevalence, Pathophysiology, and Guidelines

2. IV Iron Preparations5,6
• Polypharmacy
• Poor adherence
• GI toxicity
• Ineffective
• Iron dextran (HMW)
• Iron dextran (LMW)
• IV ferric gluconate
• IV iron sucrose
• Ferumoxytol injection
• IV ferric carboxymaltose
IV Iron Sucrose and IV Ferric Carboxymaltose in HF:
Summary of Clinical Outcomes7
FAIR-HFpEF8
N = 200; FCM, PBO
PREFER-HF9
N = 72; FCM, FS, SI, PBO
HFpEF Jun 2020Jul 2019
FAIR-HF210
N = 1,200; FCM, PBO
IRONMAN11
N = 1,300; IIM ± SOC
HEART-FID12
N = 3,014; FCM, PBO
HFrEF Oct 2020 Feb 2021 Jun 2022
Affirm-AHF13
N = 1,100; FCM, PBO
Acute HF Aug 2020
• 6MWD
• QOL
• LVEF
• Peak VO2
• NYHA class
• Hospitalization
• NT-proBNP
IV Iron
Emerging Evidence
IV Iron
Current Knowledge
Oral Iron4
• Safe
• Simple administration
• Inexpensive
Recognizing and Treating Iron Deficiency in Patients With Heart Failure:
Achieving Better Outcomes and Quality of Life
Full references, accreditation, and disclosure information available at PeerView.com/FCG930
Managing Iron Deficiency in Patients With Heart Failure