Co-Chairs and Presenter Marianne Davies, DNP, ACNP, AOCNP, FAAN, Beth Sandy, MSN, CRNP, FAPO, and Matthew A. Gubens, MD, MS, FASCO, prepared useful Practice Aids pertaining to NSCLC for this CME/MOC/NCPD/ILNA/IPCE activity titled “Making Patient-Centric Immunotherapy a Reality in Lung Cancer: Best Practices for Patient Education, irAE Management, and Survivorship Care.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/NCPD/ILNA/IPCE information, and to apply for credit, please visit us at https://bit.ly/3RDokbZ. CME/MOC/NCPD/ILNA/IPCE credit will be available until May 24, 2025.
Co-Chairs, Jessica Donington, MD, and Jonathan D. Spicer, MD, PhD, FRCSC, prepared useful Practice Aids pertaining to lung cancer for this CME/MOC/AAPA activity titled “Transforming Care and Outcomes With Immunotherapy in Stage I-III Resectable NSCLC: A Case Exploration of New Standards and Emerging Approaches.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at https://bit.ly/3TxdcP5. CME/MOC/AAPA credit will be available until June 7, 2025.
Chair and Presenters Sumanta Kumar Pal, MD, FASCO, Prof. Laurence Albiges, MD, PhD, and David F. McDermott, MD, prepared useful Practice Aids pertaining to renal cell carcinoma for this CME/MOC/AAPA activity titled “Leveling Up Our RCC Care Strategy: Real-World Translation of Key Evidence Across Treatment Settings.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at https://bit.ly/3LtPuyF. CME/MOC/AAPA credit will be available until December 10, 2024.
Daniel Pallin, MD, MPH, and Douglas B. Johnson, MD, MSCI, prepared useful practice aids pertaining to immune-related adverse events for this CME/MOC/CE activity titled "Emergency Medicine and Immuno-Oncology Intersect: Recognizing and Managing Cancer Immunotherapy–Related Adverse Effects in the Emergency Department." For the full presentation, monograph, complete CME/MOC/CE information, and to apply for credit, please visit us at http://bit.ly/2PRv8Ul. CME/MOC/CE credit will be available until November 20, 2019.
Lupus is a chronic autoimmune disease that occurs when a person's immune system attacks their own tissues and organs. Learn about the symptoms of lupus, how it is diagnosed and new treatment options to live well with lupus.
Chair, David M. O'Malley, MD, Ana Oaknin, MD, PhD, and Matthew A. Powell, MD, prepared useful Practice Aids pertaining to endometrial cancer for this CME/MOC/AAPA activity titled “Endometrial Cancer Care in the Age of Immunotherapy: Translating Clinical Evidence Into Meaningful Improvements in Patient Outcomes Across the Disease Continuum.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at https://bit.ly/40bmalK. CME/MOC/AAPA credit will be available until July 3, 2024.
A healthy immune system defends the body against disease and infection. But if the immune system malfunctions, it mistakenly attacks healthy cells, tissues, and organs. Called autoimmune disease, these attacks can affect any part of the body, weakening bodily function and even turning life-threatening.
Chair and Presenters Kathleen N. Moore, MD, MS, Floor J. Backes, MD, and Bhavana Pothuri, MD, MS, prepared useful Practice Aids pertaining to endometrial cancer for this CME/MOC/NCPD/AAPA/IPCE activity titled “Redefining Endometrial and Ovarian Carcinoma Care: Maximizing the Clinical Potential of Immunotherapy, ADCs, PARP Inhibitors, and Other Emerging Treatment Strategies.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at https://bit.ly/3SjJyuH. CME/MOC/NCPD/AAPA/IPCE credit will be available until April 17, 2025.
Co-Chairs, Jessica Donington, MD, and Jonathan D. Spicer, MD, PhD, FRCSC, prepared useful Practice Aids pertaining to lung cancer for this CME/MOC/AAPA activity titled “Transforming Care and Outcomes With Immunotherapy in Stage I-III Resectable NSCLC: A Case Exploration of New Standards and Emerging Approaches.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at https://bit.ly/3TxdcP5. CME/MOC/AAPA credit will be available until June 7, 2025.
Chair and Presenters Sumanta Kumar Pal, MD, FASCO, Prof. Laurence Albiges, MD, PhD, and David F. McDermott, MD, prepared useful Practice Aids pertaining to renal cell carcinoma for this CME/MOC/AAPA activity titled “Leveling Up Our RCC Care Strategy: Real-World Translation of Key Evidence Across Treatment Settings.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at https://bit.ly/3LtPuyF. CME/MOC/AAPA credit will be available until December 10, 2024.
Daniel Pallin, MD, MPH, and Douglas B. Johnson, MD, MSCI, prepared useful practice aids pertaining to immune-related adverse events for this CME/MOC/CE activity titled "Emergency Medicine and Immuno-Oncology Intersect: Recognizing and Managing Cancer Immunotherapy–Related Adverse Effects in the Emergency Department." For the full presentation, monograph, complete CME/MOC/CE information, and to apply for credit, please visit us at http://bit.ly/2PRv8Ul. CME/MOC/CE credit will be available until November 20, 2019.
Lupus is a chronic autoimmune disease that occurs when a person's immune system attacks their own tissues and organs. Learn about the symptoms of lupus, how it is diagnosed and new treatment options to live well with lupus.
Chair, David M. O'Malley, MD, Ana Oaknin, MD, PhD, and Matthew A. Powell, MD, prepared useful Practice Aids pertaining to endometrial cancer for this CME/MOC/AAPA activity titled “Endometrial Cancer Care in the Age of Immunotherapy: Translating Clinical Evidence Into Meaningful Improvements in Patient Outcomes Across the Disease Continuum.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at https://bit.ly/40bmalK. CME/MOC/AAPA credit will be available until July 3, 2024.
A healthy immune system defends the body against disease and infection. But if the immune system malfunctions, it mistakenly attacks healthy cells, tissues, and organs. Called autoimmune disease, these attacks can affect any part of the body, weakening bodily function and even turning life-threatening.
Chair and Presenters Kathleen N. Moore, MD, MS, Floor J. Backes, MD, and Bhavana Pothuri, MD, MS, prepared useful Practice Aids pertaining to endometrial cancer for this CME/MOC/NCPD/AAPA/IPCE activity titled “Redefining Endometrial and Ovarian Carcinoma Care: Maximizing the Clinical Potential of Immunotherapy, ADCs, PARP Inhibitors, and Other Emerging Treatment Strategies.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at https://bit.ly/3SjJyuH. CME/MOC/NCPD/AAPA/IPCE credit will be available until April 17, 2025.
Chair, Jessica Donington, MD, David H. Harpole Jr., MD, and Jonathan D. Spicer, MD, PhD, FRCSC, prepared useful Practice Aids pertaining to NSCLC for this CME/MOC/AAPA activity titled “Unleashing the Potential of Perioperative Immunotherapy in Resectable NSCLC: Leveraging Science, Enhancing Collaboration, and Improving Outcomes With Neoadjuvant and/or Adjuvant Checkpoint Inhibition.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at https://bit.ly/3OtwGAh. CME/MOC/AAPA credit will be available until October 22, 2024.
Chair & Presenter, Nancy P. Moldawer, RN, MSN, Archana Ajmera, MSN, ANP-BC, AOCNP, and Rana R. McKay, MD, prepared useful Practice Aids pertaining to renal cell carcinoma for this CME/NCPD/ILNA activity titled “Aligning Nursing Care Strategies With Evolving Patient Needs in RCC: Interprofessional Insights on Optimizing Outcomes With Novel Targeted and Immune-Based Therapies.” For the full presentation, downloadable Practice Aids, and complete CME/NCPD/ILNA information, and to apply for credit, please visit us at https://bit.ly/3tubZd0. CME/NCPD/ILNA credit will be available until May 31, 2023.
Chair, Jamie E. Chaft, MD, and Jonathan D. Spicer, MD, PhD, FRCSC, prepared useful Practice Aids pertaining to NSCLC for this CME/MOC/CC/NCPD activity titled “Marking New Milestones With Immunotherapy in Locally Advanced and Early Lung Cancer: Latest Data Informing Best Practices for Multimodal Management of Stage I-III NSCLC.” For the full presentation, downloadable Practice Aids and complete CME/MOC/CC/NCPD information, and to apply for credit, please visit us at https://bit.ly/3fcc3qs. CME/MOC/CC/NCPD credit will be available until July 11, 2022.
Linda R. Duska, MD, MPH, prepared useful practice aids pertaining to endometrial and cervical cancers for this CME/MOC activity titled Chair’s Take on Advances in Gynecologic Cancer Care: Exploring New Advances and Innovative Therapies in Endometrial and Cervical Cancers. For the full presentation, monograph, complete CME/MOC information, and to apply for credit, please visit us at https://bit.ly/2Uk5F72. CME/MOC credit will be available until June 17, 2021.
Systemic Lupus erythematous , is world wide health problem
Here we talk about criteria for diagnosis investigation , Management and complication
With some scenarios to about disease and complication
Dr Richard Schloeffel - Chronic Fatigue Syndrome Diagnosis and TreatmentPeer Support Network
Emerge Australia seminar 13 September 2014.
Dr Richard Schloeffel graduated in 1978 from NSW Uni with post -graduate training in isolated rural general practice. He worked in country practices for thirteen years and spent five years working in the developing world, including Papua New Guinea, China, India, Bali and Eastern Europe. For the last twenty years He has been the principal at ‘Pymble Grove Health Centre’ where he has been treating and specializing in complex and chronic disorders with an integrative team of practitioners.
This broad experience has been invaluable in developing the diagnosis and treatment of chronic disorders and the ability to look beyond the existing paradigms to a deeper and more profound understanding of complex disease, particularly Chronic Fatigue Syndrome, Borreliosis and its co-infections and Auto Immune Disease.
Dr Schloeffel has treated over three and a half thousand patients with Chronic Fatigue Syndrome and related disorders, refining diagnosis and appropriate investigations and management protocols. He has lectured widely on CFS and is currently undertaking research at Sydney University into Australian Lyme Disease.
Co-Chairs, Brett Elicker, MD, and David E. Griffith, MD, ATSF, ACCP, OFRSM, prepared useful Practice Aids pertaining to non-cystic fibrosis bronchiectasis for this CME/MOC activity titled “Bridging the Gap to Improved Outcomes in Non-Cystic Fibrosis Bronchiectasis: Ensuring Prompt Diagnosis Through Accurate Interpretation of CT Imaging.” For the full presentation, downloadable Practice Aids, and complete CME/MOC information, and to apply for credit, please visit us at https://bit.ly/48WUULu. CME/MOC credit will be available until June 4, 2025.
Co-Chairs, Brett Elicker, MD, and David E. Griffith, MD, ATSF, ACCP, OFRSM, discuss non-cystic fibrosis bronchiectasis in this CME/MOC activity titled “Bridging the Gap to Improved Outcomes in Non-Cystic Fibrosis Bronchiectasis: Ensuring Prompt Diagnosis Through Accurate Interpretation of CT Imaging.” For the full presentation, downloadable Practice Aids, and complete CME/MOC information, and to apply for credit, please visit us at https://bit.ly/48WUULu. CME/MOC credit will be available until June 4, 2025.
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Chair, Jessica Donington, MD, David H. Harpole Jr., MD, and Jonathan D. Spicer, MD, PhD, FRCSC, prepared useful Practice Aids pertaining to NSCLC for this CME/MOC/AAPA activity titled “Unleashing the Potential of Perioperative Immunotherapy in Resectable NSCLC: Leveraging Science, Enhancing Collaboration, and Improving Outcomes With Neoadjuvant and/or Adjuvant Checkpoint Inhibition.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at https://bit.ly/3OtwGAh. CME/MOC/AAPA credit will be available until October 22, 2024.
Chair & Presenter, Nancy P. Moldawer, RN, MSN, Archana Ajmera, MSN, ANP-BC, AOCNP, and Rana R. McKay, MD, prepared useful Practice Aids pertaining to renal cell carcinoma for this CME/NCPD/ILNA activity titled “Aligning Nursing Care Strategies With Evolving Patient Needs in RCC: Interprofessional Insights on Optimizing Outcomes With Novel Targeted and Immune-Based Therapies.” For the full presentation, downloadable Practice Aids, and complete CME/NCPD/ILNA information, and to apply for credit, please visit us at https://bit.ly/3tubZd0. CME/NCPD/ILNA credit will be available until May 31, 2023.
Chair, Jamie E. Chaft, MD, and Jonathan D. Spicer, MD, PhD, FRCSC, prepared useful Practice Aids pertaining to NSCLC for this CME/MOC/CC/NCPD activity titled “Marking New Milestones With Immunotherapy in Locally Advanced and Early Lung Cancer: Latest Data Informing Best Practices for Multimodal Management of Stage I-III NSCLC.” For the full presentation, downloadable Practice Aids and complete CME/MOC/CC/NCPD information, and to apply for credit, please visit us at https://bit.ly/3fcc3qs. CME/MOC/CC/NCPD credit will be available until July 11, 2022.
Linda R. Duska, MD, MPH, prepared useful practice aids pertaining to endometrial and cervical cancers for this CME/MOC activity titled Chair’s Take on Advances in Gynecologic Cancer Care: Exploring New Advances and Innovative Therapies in Endometrial and Cervical Cancers. For the full presentation, monograph, complete CME/MOC information, and to apply for credit, please visit us at https://bit.ly/2Uk5F72. CME/MOC credit will be available until June 17, 2021.
Systemic Lupus erythematous , is world wide health problem
Here we talk about criteria for diagnosis investigation , Management and complication
With some scenarios to about disease and complication
Dr Richard Schloeffel - Chronic Fatigue Syndrome Diagnosis and TreatmentPeer Support Network
Emerge Australia seminar 13 September 2014.
Dr Richard Schloeffel graduated in 1978 from NSW Uni with post -graduate training in isolated rural general practice. He worked in country practices for thirteen years and spent five years working in the developing world, including Papua New Guinea, China, India, Bali and Eastern Europe. For the last twenty years He has been the principal at ‘Pymble Grove Health Centre’ where he has been treating and specializing in complex and chronic disorders with an integrative team of practitioners.
This broad experience has been invaluable in developing the diagnosis and treatment of chronic disorders and the ability to look beyond the existing paradigms to a deeper and more profound understanding of complex disease, particularly Chronic Fatigue Syndrome, Borreliosis and its co-infections and Auto Immune Disease.
Dr Schloeffel has treated over three and a half thousand patients with Chronic Fatigue Syndrome and related disorders, refining diagnosis and appropriate investigations and management protocols. He has lectured widely on CFS and is currently undertaking research at Sydney University into Australian Lyme Disease.
Immune check point inhibitors and adverse effectsSCGH ED CME
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Similar to Making Patient-Centric Immunotherapy a Reality in Lung Cancer: Best Practices for Patient Education, irAE Management, and Survivorship Care (20)
Co-Chairs, Brett Elicker, MD, and David E. Griffith, MD, ATSF, ACCP, OFRSM, prepared useful Practice Aids pertaining to non-cystic fibrosis bronchiectasis for this CME/MOC activity titled “Bridging the Gap to Improved Outcomes in Non-Cystic Fibrosis Bronchiectasis: Ensuring Prompt Diagnosis Through Accurate Interpretation of CT Imaging.” For the full presentation, downloadable Practice Aids, and complete CME/MOC information, and to apply for credit, please visit us at https://bit.ly/48WUULu. CME/MOC credit will be available until June 4, 2025.
Co-Chairs, Brett Elicker, MD, and David E. Griffith, MD, ATSF, ACCP, OFRSM, discuss non-cystic fibrosis bronchiectasis in this CME/MOC activity titled “Bridging the Gap to Improved Outcomes in Non-Cystic Fibrosis Bronchiectasis: Ensuring Prompt Diagnosis Through Accurate Interpretation of CT Imaging.” For the full presentation, downloadable Practice Aids, and complete CME/MOC information, and to apply for credit, please visit us at https://bit.ly/48WUULu. CME/MOC credit will be available until June 4, 2025.
Co-Chairs, Jonathan E. McConathy, MD, PhD, and Gil Rabinovici, MD, discuss Alzheimer's disease in this CME/AAPA activity titled “Applying Advances in PET Imaging to Facilitate the Early Diagnosis of Alzheimer’s Disease: Preparing Nuclear Medicine and Radiology Specialists for New Diagnostic Workflows.” For the full presentation, downloadable Practice Aids, and complete CME/AAPA information, and to apply for credit, please visit us at https://bit.ly/45RFl6g. CME/AAPA credit will be available until June 15, 2025.
Co-Chairs Sarah Hayward, PharmD, BCOP, and Ambar Khan, PharmD, BCOP, discuss endometrial and cervical cancers in this CME/CPE/IPCE activity titled “A Pharmacist’s Take on Navigating the Expanding Therapeutic Landscape for Endometrial and Cervical Cancers: Insights on Coordinating and Delivering Effective Modern Care.” For the full presentation, downloadable Practice Aids, and complete CME/CPE/IPCE information, and to apply for credit, please visit us at https://bit.ly/3wGBPQp. CME/CPE/IPCE credit will be available until May 27, 2025.
Co-Chairs, Suzanne Lentzsch, MD, PhD, and Joshua Richter, MD, discuss multiple myeloma in this CME activity titled “‘Four-Ward’ Progress in NDMM: New Developments With CD38 Antibody Quadruplets.” For the full presentation and complete CME information, and to apply for credit, please visit us at https://bit.ly/3x3oWA3. CME credit will be available until May 23, 2025.
Co-Chairs, Jessica Donington, MD, and Jonathan D. Spicer, MD, PhD, FRCSC, discuss lung cancer in this CME/MOC/AAPA activity titled “Transforming Care and Outcomes With Immunotherapy in Stage I-III Resectable NSCLC: A Case Exploration of New Standards and Emerging Approaches.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at https://bit.ly/3TxdcP5. CME/MOC/AAPA credit will be available until June 7, 2025.
Chair Oliver Sartor, MD, discusses prostate cancer in this CME activity titled “On Target: Understanding the Impact of PSMA for Diagnostic and Therapeutic Strategies in Prostate Cancer.” For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at https://bit.ly/49oY4IJ. CME credit will be available until May 23, 2025.
Chair and Presenters, Neal D. Shore, MD, FACS, Ashish M. Kamat, MD, MBBS, and Joshua J. Meeks, MD, PhD, prepared useful Practice Aids pertaining to bladder cancer for this CME/MOC/NCPD/AAPA/IPCE activity titled “Harnessing Innovation in Bladder Cancer Care: Strategies for Effectively Implementing Modern Therapeutic Advances Across the Disease Continuum.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at https://bit.ly/3PH0RVQ. CME/MOC/NCPD/AAPA/IPCE credit will be available until June 2, 2025.
Chair and Presenters, Neal D. Shore, MD, FACS, Ashish M. Kamat, MD, MBBS, and Joshua J. Meeks, MD, PhD, discuss bladder cancer in this CME/MOC/NCPD/AAPA/IPCE activity titled “Harnessing Innovation in Bladder Cancer Care: Strategies for Effectively Implementing Modern Therapeutic Advances Across the Disease Continuum.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at https://bit.ly/3PH0RVQ. CME/MOC/NCPD/AAPA/IPCE credit will be available until June 2, 2025.
Chair, Nicholas J. Short, MD, discusses acute lymphoblastic leukemia in this CME/NCPD/CPE/AAPA/IPCE activity titled “Striking Back at ALL: Achieving Lasting Benefits with Bispecific Antibodies & MRD-Guided Strategies Across Disease Settings.” For the full presentation, downloadable Practice Aids, and complete CME/NCPD/CPE/AAPA/IPCE information, and to apply for credit, please visit us at https://bit.ly/42QsTDT. CME/NCPD/CPE/AAPA/IPCE credit will be available until May 22, 2025.
Chair, Sharon Cohen, MD, FRCPC, prepared useful Practice Aids pertaining to Alzheimer’s disease for this CME/MOC/AAPA activity titled “Specialty Training for the New Era in Alzheimer’s Disease: Building Skills for Making an Early Diagnosis and Implementing Disease-Modifying Treatment.” For the full presentation, downloadable Practice Aids, monograph, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at https://bit.ly/472bp8g. CME/MOC/AAPA credit will be available until May 20, 2025.
Chair, Sharon Cohen, MD, FRCPC, discusses Alzheimer’s disease in this CME/MOC/AAPA activity titled “Specialty Training for the New Era in Alzheimer’s Disease: Building Skills for Making an Early Diagnosis and Implementing Disease-Modifying Treatment.” For the full presentation, downloadable Practice Aids, monograph, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at https://bit.ly/472bp8g. CME/MOC/AAPA credit will be available until May 20, 2025.
Chair and Presenter, Beth Faiman, PhD, MSN, APN-BC, AOCN, BMTCN, FAAN, FAPO, Donna D. Catamero, ANP-BC, OCN, CCRC, and Charise Gleason, MSN, NP-C, AOCNP, discuss multiple myeloma in this CME/MOC/NCPD/ILNA/IPCE activity titled “Ten Steps for Highly Successful Myeloma Care: Guidance on the Road to Remission With Antibodies, BCMA Immunotherapy, and Other Innovations.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/NCPD/ILNA/IPCE information, and to apply for credit, please visit us at https://bit.ly/47mtUnM. CME/MOC/NCPD/ILNA/IPCE credit will be available until May 25, 2025.
Co-Chairs and Presenter Marianne Davies, DNP, ACNP, AOCNP, FAAN, Beth Sandy, MSN, CRNP, FAPO, and Matthew A. Gubens, MD, MS, FASCO, discuss NSCLC in this CME/MOC/NCPD/ILNA/IPCE activity titled “Making Patient-Centric Immunotherapy a Reality in Lung Cancer: Best Practices for Patient Education, irAE Management, and Survivorship Care.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/NCPD/ILNA/IPCE information, and to apply for credit, please visit us at https://bit.ly/3RDokbZ. CME/MOC/NCPD/ILNA/IPCE credit will be available until May 24, 2025.
Co-Chairs, Sia Daneshmand, MD, and Matthew D. Galsky, MD, discuss bladder cancer in this CME/MOC/NCPD/AAPA/IPCE activity titled “Modern Team-Based Therapeutic Management for Bladder Cancer Care: Expert Strategies for Integrating the Latest Evidence and Treatment Advances.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at https://bit.ly/3OOeYbO. CME/MOC/NCPD/AAPA/IPCE credit will be available until May 13, 2025.
Chair Jamie Carroll, APRN, CNP, MSN, discusses breast cancer in this NCPD/ILNA/AAPA activity titled “Nurses at the Forefront of Maximizing the Potential of TROP2-Targeted Therapy in TNBC and HR+, HER2- Breast Cancer: Best Practices for Adverse Event Management and Patient Education.” For the full presentation, downloadable Practice Aids, and complete NCPD/ILNA/AAPA information, and to apply for credit, please visit us at https://bit.ly/3SdnvWt. NCPD/ILNA/AAPA credit will be available until May 8, 2025.
Chair Jonathan A. Bernstein, MD, discusses chronic spontaneous urticaria in this CME activity titled “BTK Inhibition Transforming the Landscape of Chronic Spontaneous Urticaria Treatment.” For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at https://bit.ly/3P0cnvi. CME credit will be available until May 6, 2025.
Co-Chairs Milind Desai, MD, MBA, FACC, FAHA, FESC, and Andrew Willeford, PharmD, PhD, BCCP, prepared useful Practice Aids pertaining to hypertrophic cardiomyopathy for this CME/MOC/CPE/AAPA/IPCE activity titled “Adapting Managed Care Strategies in the Era of Precision Medicine for Hypertrophic Cardiomyopathy.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/CPE/AAPA/IPCE information, and to apply for credit, please visit us at https://bit.ly/4bb7eKc. CME/MOC/CPE/AAPA/IPCE credit will be available until May 16, 2025.
Co-Chairs Milind Desai, MD, MBA, FACC, FAHA, FESC, and Andrew Willeford, PharmD, PhD, BCCP, discuss hypertrophic cardiomyopathy in this CME/MOC/CPE/AAPA/IPCE activity titled “Adapting Managed Care Strategies in the Era of Precision Medicine for Hypertrophic Cardiomyopathy.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/CPE/AAPA/IPCE information, and to apply for credit, please visit us at https://bit.ly/4bb7eKc. CME/MOC/CPE/AAPA/IPCE credit will be available until May 16, 2025.
Chair A. Michael Lincoff, MD, discusses obesity in this CME activity titled “Exploring the Evidence: Improving Cardiovascular Outcomes and the Role of Weight Loss Pharmacotherapy.” For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at https://bit.ly/3KAO98K. CME credit will be available until April 25, 2025.
More from PVI, PeerView Institute for Medical Education (20)
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Mastering Wealth: A Path to Financial FreedomFatimaMary4
### Understanding Wealth: A Comprehensive Guide
Wealth is a multifaceted concept that extends beyond mere financial assets. It encompasses a range of elements including money, investments, property, and other valuable resources. However, true wealth also includes non-material aspects such as health, relationships, and personal fulfillment. This guide delves into the various dimensions of wealth, exploring how it can be created, sustained, and enjoyed.
#### Defining Wealth
Traditionally, wealth is defined as the abundance of valuable resources or material possessions. It includes financial assets like cash, savings, stocks, bonds, and real estate. However, a broader understanding of wealth considers factors such as personal well-being, emotional health, social connections, and intellectual growth. This holistic view recognizes that true wealth is not solely about accumulating money but also about enhancing one's quality of life.
#### The Importance of Financial Wealth
Financial wealth remains a critical component of overall wealth. It provides security, freedom, and the ability to pursue opportunities. Key elements of financial wealth include:
1. **Savings**: Money set aside for future use. It is crucial for emergencies, large purchases, and financial goals.
2. **Investments**: Assets purchased with the expectation that they will generate income or appreciate over time. Common investments include stocks, bonds, mutual funds, real estate, and businesses.
3. **Income**: Regular earnings from work, investments, or other sources. Consistent income is essential for maintaining and growing wealth.
4. **Debt Management**: Effectively managing debt ensures that it does not erode financial wealth. This includes paying off high-interest debt and using credit wisely.
#### Creating Wealth
Creating wealth involves generating and accumulating financial and non-financial resources. The process can be broken down into several key strategies:
1. Education and Skill Development: Investing in education and skills enhances earning potential. Higher education, professional certifications, and continuous learning can lead to better job opportunities and higher salaries.
2. Entrepreneurship: Starting and running a successful business can be a significant source of wealth. Entrepreneurship requires innovation, risk-taking, and effective management.
3. Investing: Making smart investments is essential for wealth creation. This involves understanding different types of investments, assessing risks, and making informed decisions. Diversifying investments can reduce risk and increase potential returns.
4. Saving and Budgeting: Effective saving and budgeting help accumulate wealth over time. Setting financial goals, creating a budget, and sticking to it are foundational steps in wealth creation.
5. Real Estate: Investing in property can provide rental income and capital appreciation. Real estate is a tangible asset that can hedge against inflation
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
EATING DISORDERS (Psychiatry-7)by dr Shivam sharma.pptxShivam Sharma
For any queries ,contact shvmshrm@outlook.com
---
## Introduction to Eating Disorders
Welcome to this comprehensive presentation on Eating Disorders, a critical and often misunderstood area of mental health. This presentation is designed to provide in-depth knowledge and insights into the various aspects of eating disorders, making it valuable for both postgraduate medical aspirants preparing for the INI-CET and the general public seeking to understand these complex conditions.
### Objectives:
1. **Understanding Eating Disorders**: Gain a clear understanding of what eating disorders are, their types, and their distinguishing characteristics.
2. **Etiology and Risk Factors**: Explore the underlying causes and risk factors that contribute to the development of eating disorders.
3. **Clinical Features and Diagnosis**: Learn about the clinical features, diagnostic criteria, and the importance of early detection.
4. **Management and Treatment**: Review the current approaches to managing and treating eating disorders, including medical, psychological, and nutritional interventions.
5. **Prevention and Awareness**: Discuss strategies for prevention, early intervention, and increasing awareness about eating disorders.
This presentation aims to bridge the gap between academic knowledge and practical understanding, providing you with the tools to recognize, diagnose, and effectively manage eating disorders. Whether you are preparing for a medical exam or seeking to educate yourself or others about these serious conditions, this presentation will equip you with essential information and practical insights.
Let's begin our journey into understanding eating disorders and the significant impact they have on individuals and society.
---
For any queries ,contact shvmshrm@outlook.com
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Non-Invasive assessment of arterial stiffness in advanced heart failure patie...
Making Patient-Centric Immunotherapy a Reality in Lung Cancer: Best Practices for Patient Education, irAE Management, and Survivorship Care
1. Immune-Related Adverse Events of Cancer Immunotherapies
Become Aware and Stay Vigilant1-15
Full abbreviations, accreditation, and disclosure information available at PeerView.com/XRX40
Immune Checkpoint Inhibitors (ICIs)
• Monoclonal antibodies against CTLA-4,
PD-1, or PD-L1
• ICIs have transformed the treatment of
many cancer types
• In some cases, ICIs are associated with
immune-related adverse events (irAEs)
Management of irAEs
• Treatment depends on the affected organ
and severity of symptoms
• ICIs should be halted following irAE
diagnosis in most patients, except those
with very mild symptoms
• Glucocorticoids are the first-line therapy for
most severe irAEs, following which,
nonsteroidal synthetic immunosuppressive
agents or intravenous immunoglobulin can be
used if symptoms do not improve within
48-72 hours
• Monoclonal antibody therapy against, for
example, TNF or IL-6, or plasma exchange
can be used for some irAEs
• Deciding when to recommence ICI therapy to
continue cancer treatment should be
undertaken by a multidisciplinary team
comprising organ specialists and oncologists
• ICIs should be permanently discontinued in
individuals with grade 3 myocarditis,
pneumonitis, and hepatitis, among others,
and all grade 4 irAEs
Outlook
• Some studies have identified biomarkers
associated with a higher risk of irAEs, such
as pretreatment levels of serum
autoantibodies
• Further studies are required before
autoantibodies can be used to guide
management strategies in clinical practice
• Studies will be needed to characterize the
associated risk, frequency, and
manifestations of irAEs as new ICIs or
combinations are approved
DIAGNOSIS
Diagnostic
workup of
individuals
with suspected
irAEs depends
on the affected
organ
Systemic
Sicca syndrome and vasculitis
irAEs can
range in
severity
and affect
almost any
organ
Polyneuropathy
Uveitis
Interstitial
lung
disease
Hepatitis
Vitiligo
Myalgia
and
myositis
Enterocolitis
Thyroiditis
Hypophysitis
Myocarditis
Adrenitis
Arthralgia
and
arthritis
Epidemiology of irAEs
• Onset generally occurs between 2 and 16
weeks after ICI initiation depending on the
affected organ
• Some reports of onset within a few days of
starting therapy and >1 year after completion
• In general, PD-1 and PD-L1 inhibitors are
tolerated better than CTLA-4 inhibitors
• ICI monotherapy is associated with fewer
irAEs than PD-1/PD-L1 and CTLA-4
combination therapy
Preexisting autoimmune disease is a
strong risk factor for developing irAEs
Mechanisms of irAEs
• CTLA-4 inhibitors: imbalance in ratio of
regulatory T cells (which dampen the immune
response) to type 17 T helper cells (which
promote the immune response), autoantibody
production, and complement-mediated
cellular damage
• PD-1/PD-L1 inhibitors: less well-understood,
but could be due to reduced regulatory T cell
numbers
ICIs targeting the CTLA-4 or PD-1/PD-L1
pathways facilitate T-cell activation and
survival, which induce an antitumor
immune response
Monitoring organ function during ICI
therapy to enable early detection of
irAEs is warranted only for some
organs, such as thyroid and liver
Endocrine irAEs of all severities should be
treated with hormone supplementation
2. Immune-Related Adverse Events of Cancer Immunotherapies
Become Aware and Stay Vigilant1-15
Full abbreviations, accreditation, and disclosure information available at PeerView.com/XRX40
Society for Immunotherapy of Cancer (SITC) Consensus Definitions for irAEs
Recurrent irAEs
• Occur in the same organ
• Occur at least twice after IO
discontinuation
Steroid-unresponsive irAEs
• No clinical improvement after a
standard timeframe of guideline-based
irAE-directed steroid therapy
• Steroid-refractory irAEs derived no
clinical benefit from steroids
Steroid-resistant irAEs
• Derived some clinical benefit without
resolution of the event
Steroid-dependent irAEs
• Some improvement with guideline-
based irAE-directed steroid therapy;
however, a taper is not possible
• irAEs requiring ongoing steroids for
≥12 weeks are “chronically
steroid dependent”
Delayed/late-onset irAEs
• Occur >3 months after ICI
discontinuation
Chronic irAEs
• Persist beyond 3 months of ICI
discontinuation
Two subtypes
1. Chronic + active: ongoing
inflammation, requires ongoing
immunosuppression
2. Chronic + inactive: absence of
ongoing inflammation, not requiring
ongoing immunosuppression
Natural History of irAEs
Multisystem irAEs
• Occur concomitantly with another irAE
or during treatment for the first irAE
• irAEs occurring in the same or
different organ system
• If occurring in the same system, they
affect different tissues
Patterns of irAEs Response to irAE Treatment
3. Immune-Related Adverse Events of Cancer Immunotherapies
Become Aware and Stay Vigilant1-15
Full abbreviations, accreditation, and disclosure information available at PeerView.com/XRX40
Organ-Specific irAE Management Recommendations
Rash, pruritus, psoriasis, eczema, lichenoid deposits, vitiligo, blistering, skin sloughing, DRESS, bullous pemphigoid, Stevens-Johnson syndrome, toxic epidermal necrolysis
Colitis
Dermatologic irAEs
Gastrointestinal irAEs
• Mild (<10% BSA)
• With/without other symptoms
(pruritus, burning)
• Moderate (10%-30% BSA)
• With/without other symptoms
• Limited IADLs
• Severe >30% BSA
• Limited self-care ADLs
• Potentially life threatening
• Pustules, sloughing, superinfection
• <4 stools >baseline
• Mild increase in ostomy output
• Asymptomatic
• 4-6 stools >baseline
• Limited ADLs
• Abdominal cramps/pain
• >6 stools >baseline
• Limited self-care ADLs
• Severe abdominal pain
• Life threatening
• Hemodynamically unstable
G1
G3
G4
G2
G1
G3
G4
G2
Pruritis
Rash
Peeling or blisters
Oral lesions
Anal, genitourinary, vaginal lesions
Increase in stool frequency
Increase in ostomy output
Blood or mucous in stool
Abdominal cramping/pain
Urgency or incontinence
Dietary modifications (BRAT)
Hydration
Antispasmodics
Antidiarrheals
Refractory: infliximab, vedolizumab
Topical emollients
Oral antihistamines
Gabapentin
Consults: dermatology, ophthalmology,
infectious disease
Refractory pruritus: treat with dupilumab
and omalizumab
Total body exam, including mucosa
Distribution of rash
Presence of peeling or blisters
Prior history of dermatologic autoimmune disease
(eczema, psoriasis, scleroderma)
Refractory bullous dermatitis and
Stevens-Johnson syndrome:
treat with rituximab, IVIG, or cyclosporin
Frequency and volume of diarrhea
Level of opioid constipation
Medications: antibiotics, bowel medications
Stool cultures: C. diff., O&P, Giardia, viral, etc.
Rule out other causes:
diet, infection, medications
Report Assess Support
Report Assess Support
Rule out other causes
• Cellulitis, infection, other drug reactions
• Severe DRESS/DIHS/TENS
4. Immune-Related Adverse Events of Cancer Immunotherapies
Become Aware and Stay Vigilant1-15
Full abbreviations, accreditation, and disclosure information available at PeerView.com/XRX40
Organ-Specific irAE Management Recommendations
Hypothyroidism, hypophysitis, adrenal insufficiency
Arthralgias, arthritis
Endocrine irAEs
Rheumatologic irAEs
• TSH >10 mIU/L
• Levothyroxine (1.6 mcg/kg/d)
• Brain MRI
• Hormone replacement
• Initiate corticosteroids before
other hormones
• Caution: must stabilize before
any surgeries
• Mild pain or only one joint involved
• Moderate pain
• Limited IADLs
• Signs of inflammation or joint swelling
• Severe pain
• Limited self-care ADLs
• Inflammation, erythema, or joint swelling
• Potentially life threatening
T
A
!
P
G1
G3
G4
G2
Fatigue
Irritability
Anorexia
Hot/cold intolerance
Headaches
Palpitations
TSH and free T4 every 4-6 weeks
FSH, LH
ACTH, morning cortisol
Estradiol, testosterone
Metabolic panel
Rule out other causes: brain metastases, infection
Report Assess Support
Report Assess Support
Levothyroxine replacement for life
Hormone replacement
Stress dose steroids
Propranolol for palpitations
Medical alert bracelet
Encourage physical exercise
Consider DMARDs
Pain management
Low-dose steroids
Corticosteroid join injection
Refractory: IVIG, plasmapheresis, methotrexate
Physical exam: joints, gait
Rheumatologic tests: ANA, RF, anti-CCP,
ESR, SK, CRP
X-ray or ultrasound
Rule out other causes: infection, injury
Joint aches or stiffness
Joint swelling
Muscle soreness
Limited ADLs
5. Immune-Related Adverse Events of Cancer Immunotherapies
Become Aware and Stay Vigilant1-15
Full abbreviations, accreditation, and disclosure information available at PeerView.com/XRX40
Organ-Specific irAE Management Recommendations
Weakness, neuropathy, myasthenia gravis, Guillain-Barré, myelitis
Elevated amylase/lipase, pancreatitis, hyperglycemia, diabetes
Neurologic irAEs
Pancreatic irAEs
• Motor: asymptomatic
• Sensory: asymptomatic, loss of
DTRs, or paresthesia
• Motor and sensory: moderate symptoms
• Limited IADLs
• Motor and sensory: severe symptoms
• Limited self-care ADLs
• Requires assistive devices
• Life threatening
G1
G3
G4
G2
G1
G2
Weakness: unilateral/bilateral
Altered gait
Motor deficits
Mental status changes
Numbness or tingling
Neuropathy
Rule out other causes: metabolic, disease
progression, chemotherapy
EMG
Functional assessment
CK, aldolase
Neuropathy panel
Sensory perception
Muscle strength
Rule out other causes: diabetes, exocrine
insufficiency, alcoholic pancreatitis, hyperlipidemia
Abdominal CT or MRCP
Abdominal exam
Urine ketones
Glucose
LFTs
Amylase, lipase
Abdominal pain
Diarrhea
Severe fatigue
Progressive symptoms when bending forward
Nausea or emesis
Hydration
Insulin (if needed)
Gabapentin for pain
Refractory: DMARDs, IVIG, plasmapheresis,
high-dose pulse steroids
Report Assess Support
Report Assess Support
Physical and occupational therapy
Two of the following
G3
G4
• Elevation of amylase/lipase >3x ULN or
radiographic findings on CT or
clinical findings
• Elevation of amylase/lipase >3x ULN,
radiographic findings, clinical findings
• Elevation of amylase/lipase,
± radiographic findings, ± severe
abdominal pain or emesis
• Hemodynamically unstable
6. Immune-Related Adverse Events of Cancer Immunotherapies
Become Aware and Stay Vigilant1-15
Full abbreviations, accreditation, and disclosure information available at PeerView.com/XRX40
Organ-Specific irAE Management Recommendations
Pneumonitis (more common with PD-1/PD-L1 inhibitors; 20%-30% mortality)
Elevated LFTs, hepatitis, ALF
Pulmonary irAEs
Hepatic irAEs
• <25% of lung, one lobe
• Asymptomatic
• Diagnostic observation
• 25%-50% of lung
• Symptomatic
• Limited ADLs
• >50% of lung
• Severe symptoms
• Limited self-care ADLs
• Oxygen support increased
• Life threatening
• Respiratory compromise
• AST/ALT: >ULN-3.0x ULN
• Total bilirubin >ULN-1.5x ULN
• AST/ALT: >3.0-5.0 x ULN
• Total bilirubin >1.5-3x ULN
• AST/ALT >5.0-20.0x ULN
• Total bilirubin >3.0-10.0x ULN
• AST/ALT >20x ULN
• Total bilirubin >10x ULN
G1
G3
G4
G2
G1
G3
G4
G2
Increased or new dyspnea
Increased oxygen requirement
Chest pain
Cough, wheezing
Smoking cessation
Possible antibiotic, nebulizers
Oxygen support
Vaccinations: influenza, COVID-19, pneumococcal
Rule out other causes: disease progression,
pulmonary embolism, effusion, infection
Oxygen saturation: rest and ambulation
Breath sounds, respiratory rate
Nasal swab
CXR or CTA (perhaps Doppler US)
Infection, reactivation of viral hepatitis
Disease progression
Alcohol use
Use of hepatotoxic drugs, supplements, chemo
Viral panel: hepatitis panel
Electrolytes
LFTs: total bilirubin, AST, ALT, ALK, phosphatase
Report Assess Support
Report Assess Support
Hydration
Infliximab is contraindicated
Limit use of hepatotoxic drugs and alcohol
Abdominal pain
Yellowing of skin
Ascites
Pruritus
Bleeding/bruising
Nausea or emesis
7. Immune-Related Adverse Events of Cancer Immunotherapies
Become Aware and Stay Vigilant1-15
Full abbreviations, accreditation, and disclosure information available at PeerView.com/XRX40
Organ-Specific irAE Management Recommendations
Myocarditis, pericarditis, heart failure
Nephritis, ARF
Cardiac irAEs
Renal irAEs
• N/A
• N/A
• Arrythmia
• Significant ECHO findings without
hypotension
• Cardiac markers >ULN
• Arrhythmia
• Hemodynamic instability (hypotension,
cardiomyopathy)
• Cardiac markers >3x ULN
• Creatinine >ULN-1.5x ULN
• Creatinine >1.5-3.0x baseline;
>1.5-3.0x ULN
• Creatinine >3.0 baseline;
>3.0-6.0x ULN
• Creatinine >6.0x ULN
• Life threatening
• Dialysis indicated
G1
G3
G4
G2
G1
G3
G4
G2
Myalgias
Ankle edema
Chest pain
Palpitations
Shortness of breath
Rule out other causes: pulmonary toxicity,
myocardial infarction
High-dose pulse steroids: 1 mg/d x 5 days
Refractory: abatacept, ATG, alemtuzumab
Report Assess Support
Report Assess Support
Oxygen support
Limit nephrotoxic drugs and use of contrast dye
If grade >2 after 4 weeks on steroids, consider
azathioprine, cyclosporine, cyclophosphamide,
infliximab, mycophenolate
Hydration
Urinalysis, urine protein, creatinine,
electrolytes, osmolality
Rule out other causes: nephrotoxic drugs,
chemotherapy, antibiotics, NSAIDs, contrast dye,
infection, pre/post renal causes
Serum creatinine, electrolytes, acid/base
Nausea
Ankle edema
Blood in urine
Decreased urine output
Blood pressure, heart rate
ECG, ECHO
Cardiac markers: CK, troponin
Inflammatory markers: ESR, CRP, BNP, NT-proBNP
8. Immune-Related Adverse Events of Cancer Immunotherapies
Become Aware and Stay Vigilant1-15
Full abbreviations, accreditation, and disclosure information available at PeerView.com/XRX40
Organ-Specific irAE Management Recommendations
Uveitis, iritis, sicca, conjunctivitis
Ocular irAEs
• Mild symptoms
• Anterior uveitis
• Posterior or pan-uveitis
• 20/200 vision
G1
G3
G4
G2
Blurred or distorted vision
Dryness
Proptosis
Tenderness
Eyelid swelling
Photophobia
Report Assess Support
Visual acuity
Rule out other causes: infection, eye irritant,
macular degeneration, glaucoma
Fundoscopic exam
Pupil size, shape, and reactivity
Artificial tears
Steroid eye ointment
Moist compresses
Sunglasses
9. Immune-Related Adverse Events of Cancer Immunotherapies
Become Aware and Stay Vigilant1-15
Full abbreviations, accreditation, and disclosure information available at PeerView.com/XRX40
Patterns and Duration of Various irAEs
Pneumonitis: most common fatal toxicity associated with PD-(L)1 monotherapy
Myocarditis: most common fatal toxicity associated with PD-(L)1/CTLA-4 combination therapy
Endocrinopathies: most common toxicities associated with PD-(L)1 monotherapy
Hepatitis: a common toxicity associated with immunotherapy and targeted therapy combinations
Cutaneous toxicities: earliest toxicity associated with PD-(L)1 monotherapy and combinations
Nephritis: a common toxicity associated with chemo-IO
4 6 8 10 12 14 >30
4 6 8 10 12 14 >30
4 6 8 10 12 14 >30
Duration of Treatment, wk Duration of Treatment, wk
CTLA-4 Inhibitor
PD-1/PD-L1 Inhibitor PD-1/PD-L1 + CTLA-4 Inhibitors
Duration of Treatment, wk
Toxicity
Grade
Toxicity
Grade
Toxicity
Grade
Colitis Liver toxicity
Skin toxicity,
rash, or pruritus
Pneumonitis
Endocrinopathy Nephritis
10. Immune-Related Adverse Events of Cancer Immunotherapies
Become Aware and Stay Vigilant1-15
Full abbreviations, accreditation, and disclosure information available at PeerView.com/XRX40
General Recommendations for Treating irAEs
The Principles of irAE Management
Increasing
intensity
of
treatment
required
Grade 2
Grade 1 Grade 3 Grade 4
Moderate
Mild Severe Very severe
Symptomatic and supportive therapy
Stop treatment
Oral steroids Intravenous steroids. ------------>
• Referral to specialist
• Strong immune suppressive treatment
Increasing grade of irAE
Intravenous steroids
Steroids (PO/IV): 1-2 mg/kg/d
prednisone or equivalent,
slowly taper over 4-6 weeks
For some AEs, treatment can be
restarted after resolution (eg, rash);
generally, ICI can be continued
with endocrinopathies
once managed
Managed in outpatient/
community setting
Generally requires
hospital admission
01 Prevention
02 Anticipation
03 Detection
04 Treatment
05 Monitoring
01
02
03
04
05
11. Immune-Related Adverse Events of Cancer Immunotherapies
Become Aware and Stay Vigilant1-15
Full abbreviations, accreditation, and disclosure information available at PeerView.com/XRX40
1. Ramos-Casals M et al. Nat Rev Dis Primers. 2020;6:38. 2. Martins F et al. Nat Rev Clin Oncol. 2019;16:563-580. 3. O’Leary CL et al. J Thorac Oncol. 2023 Oct 23 [Epub ahead of print]. 4. Helmink BA et al. Ann Surg Oncol. 2020;27:1533-1545. 5. Stiles BM et al. J Thorac Cardiovasc Surg.
2020;160:1376-1382. 6. Champiat S et al. Ann Oncol. 2016;27:559-574. 7. Brahmer JR et al. J Clin Oncol. 2018;36:1714-1786. 8. https://www.esmo.org/content/download/124130/2352601/1/ESMO-Patient-Guide-on-Immunotherapy-Side-Effects.pdf. 9. https://www.nccn.org/
professionals/physician_gls/pdf/immunotherapy.pdf. 10. Puzanov I et al. J Immunother Cancer. 2017;5:95. 11. Brahmer JR et al. J Clin Oncol. 2018;36:1714-1786. 12. Provided courtesy of Marianne Davies, DNP, ACNP, AOCNP, FAAN, 2021; adapted from AIM with Immunotherapy, NCCN,
and CTCAE. 13. Naidoo J et al. J Immunother Cancer. 2023;11:e006398. 14. https://ascopubs.org/doi/full/10.1200/JCO.21.01440. 15. https://www.sitcancer.org/research/cancer-immunotherapy-guidelines/irae/immune-checkpoint-inhibitor-related-adverse-events.
Additional Guideline Recommendations for Treating irAEs
12. LUNGevity Foundation
Lung Cancer Patient Resource Compendium
Full abbreviations, accreditation, and disclosure information available at PeerView.com/XRX40
LUNGevity is transforming how people are diagnosed and live
with lung cancer through research, education, and support
LUNGevity educational materials order form for providers:
www.lungevity.org/order-materials
The next page includes useful links to resources for patients with lung cancer
lungevity.org
13. lungevity.org
• The Lung Cancer 101 Website
provides a guide to understanding
the basics of lung cancer
• The Lung Cancer Support
Community message boards offer
24/7 peer-to-peer support and
information
• The LifeLine Program matches
patients and caregivers to mentors
LUNGevity offers the largest online network of peer-to-peer and one-on-one support,
plus in-person survivorship programs for all people affected by lung cancer
LUNGevity hosts weekly lung cancer support Virtual Meetups
for patients, survivors, caregivers, and friends and family members of people
with lung cancer to virtually connect face-to-face with others across the country
Please call 312-407-6116 for more information
• The Lung Cancer HELPLine
offers toll-free, personalized
support in English and Spanish
• Patient Gateways help navigate
specific types of lung cancer
• LUNGevity’s Hope Summit is
designed to inform, connect, and
empower anyone who has been
affected by lung cancer