New way to kill cancer cells, get them addicted to drugs

1. New way to kill cancer cells:
Get them addicted to drugs
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2. Contd…
Scientists in the UK have found a new way to combat cancer by getting
tumour cells addicted to drugs that will kill them in minutes. The
technique called “mitopriming“ was developed as a research tool while
trying to understand how cancer cells die. Mito-priming can be applied
to identify new anti-cancer drugs to screen their effectiveness.
According to the research paper, BH3-mimetics are a promising new
class of cancer drugs developed to specifically kill tumour cells. They
target a family of proteins called BCL-2 proteins, which function to keep
cancer cells alive. While not yet in use in clinical practice, BH3-mimetic
anticancer drugs are showing promise in late-stage clinical trials,
particularly in the treatment of chronic lymphocytic leukaemia.
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3. Contd…
Stephen Tait, the lead author of the paper, said, “Mito-priming can be used
to rapidly screen for new BH3-mimetics and other anti-cancer drugs, and
should improve ways to kill cancer cells. It can also be used to rapidly define
the potency and specificity of BH3-mimetics.“ Finally , the technique will
allow us to under stand how drug resistance occurs thereby allowing us to
prevent this from happening in the first place, he added.
“There is currently a lot of interest in targeting BCL2 proteins in the fight
against cancer and there will be new therapies emerging in the future,“ Tait
said. The scientists developed mito-priming by producing equal amounts of
toxic and protective BCL-2 proteins in cells.
“Cells in this state are very sensitive to inhibition of protective BCL-2 function
by BH3-mimetics, such that they die within a few minutes of drug addiction,“
Tait said.
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