Cell-mediated immunity involves T cells and other white blood cells killing pathogens inside infected cells. It responds to intracellular bacteria and viruses through T cells, macrophages, and natural killer cells without using antibodies. Some T cells become memory cells to provide a stronger secondary response if the same pathogen is encountered again. The functions of cell-mediated immunity include immune surveillance, graft rejection, hypersensitivity reactions, and immunity against various intracellular pathogens.

3. When antigens are destroyed by cells without
producing antibodies, the immunity is called cell
mediated immune response or cellular immunity.
Here T cells play a major role. B cells and
antibodies have no role in cell mediated
immunity.
In cell mediated immunity, intracellular foreign
antigens (viruses, bacteria) are killed. Protein
antigens bring about cell mediated immune
response.

4. T cells
Macrophages
Natural killer cells (NK).
Cell mediated immunity is brought about by the following cells:
When the antigen enters the body for the first time it causes
primary immune response. When the same antigen enters the
body for the second time, it produces secondary immune
response. Some of the sensitized T cells, function as memory
cells in cell mediated immune response.
CELLS RESPONSIBLE FOR CELL
MEDIATED IMMUNITY

5. BIOLOGICAL FUNCTIONS OF CELL
MEDIATED IMMUNITY
Immune surveillance
Graft rejection
Delayed type hypersensitivity reaction
Immunity to viral infection
Immunity to bacterial infection
Immunity to parasites.
The following are the functions of cell mediated immunity.
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