This document provides an introduction to immunology, outlining key concepts. It defines immunity, describes the functions of the immune system in preventing infection and maintaining homeostasis. It distinguishes between innate and acquired immunity, describing their unique characteristics. Key cells of the immune system are briefly discussed.
Serological test for virus identificationPlock Ghosh
This presentation consist of detailed study of serological method of virus identification. Basically ELISA is vastly used for virus detection. Western blot method is used for HIV identification.
this slide can help you to know full details about the major type of antigen based on its activity on B or T cell. This slide consists of images to clarify your doubts
Serological test for virus identificationPlock Ghosh
This presentation consist of detailed study of serological method of virus identification. Basically ELISA is vastly used for virus detection. Western blot method is used for HIV identification.
this slide can help you to know full details about the major type of antigen based on its activity on B or T cell. This slide consists of images to clarify your doubts
A brief covering basics of immunity understanding and also allowing students to understand with ease the concepts of innate immunity, adaptive immunity, Tcell, Bcell, MHC molecular genetics, and also cytokines and also its role in various disease.
The immune system has evolved to protect the host from a universe of pathogenic microbes that are themselves constantly evolving. The immune system also helps the host eliminate toxic or allergenic substances that enter our body. It is a host defence system comprising many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. The host uses both innate and adaptive mechanisms to detect and eliminate pathogenic foreign bodies. Both of these mechanisms include self-nonself discrimination.
The main parts of the immune system are:
• White Blood Cells
• Antibodies
• Complement System
• Lymphatic System
• Spleen
• Bone Marrow
• Thymus.
Similar to Lecture 1( Introduction to immunology).pptx (20)
The prostate is an exocrine gland of the male mammalian reproductive system
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
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The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
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1. ZERA INTERNATIONAL COLLEGE
OF HEALTH SCIENCES
DEPARTMENT OF CLINICAL MEDICINE
IMMUNOLOGY
LECTURE 1: INTRODUCTION TO IMMUNOLOGY
Mrs Natasha N Ng’andwe
BSc, BMS
2. Lecture Outline
Define immunity
Functions of the immune system
Concepts in immunology
Unique characteristics of immune responses
Comparison between innate & acquired immunity
Briefly look at cells of the immune system
3. Introduction
The term immunity, derived from the Latin “immunis” (exempt), was adopted to designate this naturally
acquired protection against diseases such as measles or smallpox.
Immunology can be described as a branch of biology that covers the study of immune systems in
organisms
The emergence of immunology as a discipline was closely tied to the development of microbiology.
The work of Pasteur, Koch, Metchnikoff, and many other pioneers of the golden age of microbiology
resulted in the rapid identification of new infectious agents, closely followed by the discovery that
infectious diseases could be prevented by exposure to killed or attenuated organisms, or to compounds
extracted from the infectious agents.
4. Functions of the immune system
Prevent or limit invasion by microorganisms.
Eliminate micro-organisms in the body.
Maintain homeostasis both external & internal body environment
5. General concepts in immunology
1. Innate (non specific) & acquired (specific) immunity.
Innate immunity (non specific) are defenses that we are born with or are present
from the time we are bone.
Acquired immunity ( specific) are defenses that are induced during the life of the
individual as part of the complex sequence of events designated as the immune
response.
7. LINES OF DEFENSE
FIRST LINE : ANATOMICAL BARRIERS
Mechanical barriers (skin & mucous membranes)
Chemical barriers (acid and antibacterial peptides)
Physiological barriers (temperature, pH)
SECOND LINE : innate immune cells
Phagocytes (monocytes/macrophages, neutrophils and dendritic cells)
Natural killer cells (NKCs)
Inflammatory cells (mast cells, basophils, eosinophils)
8. LINES OF DEFENSE
THIRD LINE: adaptive immune cells
Lymphocytes (T cells and B cells)
Humoral immunity: Immunoglobulins (antibodies)
Cell-mediated immunity: T cells
9. Unique Characteristics of the Immune
Response
1. Specificity
For example, immunization with poliovirus only protects against poliomyelitis, not
against the flu. The specificity of the immune response is due to the existence of
exquisitely discriminative antigen receptors on lymphocytes
2. Memory
The ability to remember previous responses and to react more quickly and more
intensely.
meaning that repeated exposures to a given antigen elicit progressively more
intense specific responses.
10. Stages of immune response
3 stages- induction, amplification and effector.
Induction involves recognition of antigen by specific receptors on lymphocytes
.followed by activation of the cells.
Amplification –cytokines mediate interaction between cells leading to proliferation
and differentiation of T and B lymphocytes.
Effector- elimination of pathogens by antibodies, cytotoxic T cells or macrophages.
11. Innate immunity
Exists prior to invasion (natural immunity).
Non-specific,
No memory
Intact skin and mucous membranes acts as physical barrier to invasion by
microorganisms.
Chemical properties such as gastric acid.
Antibacterial substances found in secretions e.g lysozyme
12. Innate immunity
Phagocytic cells Include neutrophils, macrophages, dendritic cells, natural killer
cells.
They Ingest and neutralize microorganisms by exposing them to proteolytic
enzymes, lipases, hydrogen peroxide etc.
They also act as antigen presenting cells to T lymphocytes bridging innate and
acquired immunity.
13. Acquired immunity
Involves 2 types ;
1. Humoral immunity:
Involves the production of antibodies in circulation that eliminate infectious agent
Mechanisms antibodies use include Neutralization/blocking, ADCC, Opsonization,
Complement fixation
2. Cell-mediated immunity:
T cells activate macrophages to kill phagocytosed microbe or kill infected cells
Cytolytic T cells kill infected cells with microbes (eg Viruses)
14.
15. Comparison Between Innate and Acquired
Immunity
Innate Immunity: 1st and 2nd line of defense
Immediate response with no improvement with repeated exposure
React against microbes but not against noninfectious substances or host tissue
Adaptive or acquired immunity (3rd line of defense)
Specificity: ability to recognize different microbes (self/non self recognition)
Flexibility (adaptability): ability to recognize newly evolved microbes (diversity)
Memory: ability to remember previous responses and to react more quickly and
more intensely
18. Cells of the immune system
Lymphocytes
B and T cells (Th/CD4 and Tc/CD8 cells)
Natural killer cells (NK cells)
Antigen presenting cells
B cells, monocytes/macrophages, dendritic cells
Cells that produce inflammatory mediators (granulocytes)
Neutrophils, basophils, eosinophils, mast cells
Important in helminth and protozoan infections
Involved in allergy
19. Immune system
Antigen
A toxin or other foreign substance which induces an immune response in the body, especially the
production of antibodies
It can also be defined as non-self substances (cells, proteins) that are recognized by immune cells,
thereby eliciting an immune response.
Antibody
Proteins found in blood and produced in response to a specific antigen
They are released by B lymphocytes. A.k.a immunoglobulins.
Cytokines
Substances / proteins made by certain immune and non-immune cells that have an effect on the
immune system
important in cell to cell communication.
Produced by a wide variety of cells including immune system cells.
Classified according to action, eg chemokines- attract cells to areas of inflammation
20. Types of immunity
Active immunity
Active Immunity results when exposure to a disease organism triggers the immune
system to produce antibodies to that disease.
Active immunity can be acquired through natural immunity or vaccine-induced.
Passive immunity
the short-term immunity which results from the introduction of antibodies from
another person or animal
It is immediately available but does not last long.
***reading assignment, differences between active & passive immunity