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By- Dr. Armaan Singh
 Identify common risk factors for renal stone
disease
 Identify common signs and symptoms for
renal stone disease
 Know the common types of renal stones
 Familiarize with basics of renal stone
management, including knowing when to
consult urology
 49 year old woman with history of
hypertension, diabetes presents with four
day history of right sided flank pain and
“pink urine.” What is the most appropriate
imaging to diagnose this patient with renal
stone disease?
 A: KUB
 B: Ultrasound
 C: Contrast-enhanced CT
 D: Non-Contrast CT
 Supersaturation of urine with solutes
 Solubility is affected by urine pH, volume
and total excretion
 Those factors can often be modified with
medications and diet
 Male sex
 Obesity
 Family History
 H/o stone disease (1/2 will have recurrence)
 Dietary factors
 Lower fluid intake, higher animal protein, higher
Vitamin C
 Medical factors
 Typical symptoms
 Sudden onset
 Unilateral colicky flank pain radiating to groin
(localization of pain evolves as stone migrates)
 Often with nausea/vomiting
 Hematuria (microscopic or gross)
 Differential for flank pain with hematuria
 UTI
 Renal Cell Carcinoma
 Ectopic pregnancy
 Dissecting AAA with renal artery involvement
 In order of prevalence
 Calcium Oxalate
 Calcium Phosphate
 Struvite
 Urice Acid
 Cystine
 Urinalysis: may show
 Hematuria (90% sensitive)
 Signs of infection
 Crystals
 Elevated pH (urea-splitting bugs?) or low pH
(RTA?)
 Metabolic workup: Consider only if recurrent
 Imaging
 Non-Contrast helical CT with Stone protocol is
the gold std (can detect stones not visible by
KUB/IVP and has significantly better
sensitivity/specificity)
 Ultrasound: For patients needing avoidance of
radiation (pregnant, childbearing age)
 IVP: No longer favored due to lower sensitivity,
HIGHER radiation exposure
 KUB: Will miss radiolucent uric acid stones, small
stones, stones with overlying bony structures.
Urologic Intervention?
 X<5mm : most pass spontaneously. Possible
observation and pain control
 X>5mm : less than 20% chance of passage and
may need urologic intervention
So when to consult urology?
 If > 5mm
 For ANY size with ….
 Urosepsis, AKI, anuria, unyielding N/V/Pain ->
Inpatient consult
 Failed conservative management and stone did not
pass spontaneously -> Inpatient or Outpatient consult
depending on severity
 Identified common risk factors for renal
stone disease
 Identified common signs and symptoms for
renal stone disease
 Know the common types of renal stones
 Familiarized with basics of renal stone
management, including knowing when to
consult urology

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Renalstones

  • 2.  Identify common risk factors for renal stone disease  Identify common signs and symptoms for renal stone disease  Know the common types of renal stones  Familiarize with basics of renal stone management, including knowing when to consult urology
  • 3.  49 year old woman with history of hypertension, diabetes presents with four day history of right sided flank pain and “pink urine.” What is the most appropriate imaging to diagnose this patient with renal stone disease?  A: KUB  B: Ultrasound  C: Contrast-enhanced CT  D: Non-Contrast CT
  • 4.  Supersaturation of urine with solutes  Solubility is affected by urine pH, volume and total excretion  Those factors can often be modified with medications and diet
  • 5.  Male sex  Obesity  Family History  H/o stone disease (1/2 will have recurrence)  Dietary factors  Lower fluid intake, higher animal protein, higher Vitamin C  Medical factors
  • 6.  Typical symptoms  Sudden onset  Unilateral colicky flank pain radiating to groin (localization of pain evolves as stone migrates)  Often with nausea/vomiting  Hematuria (microscopic or gross)
  • 7.  Differential for flank pain with hematuria  UTI  Renal Cell Carcinoma  Ectopic pregnancy  Dissecting AAA with renal artery involvement
  • 8.  In order of prevalence  Calcium Oxalate  Calcium Phosphate  Struvite  Urice Acid  Cystine
  • 9.  Urinalysis: may show  Hematuria (90% sensitive)  Signs of infection  Crystals  Elevated pH (urea-splitting bugs?) or low pH (RTA?)  Metabolic workup: Consider only if recurrent
  • 10.  Imaging  Non-Contrast helical CT with Stone protocol is the gold std (can detect stones not visible by KUB/IVP and has significantly better sensitivity/specificity)  Ultrasound: For patients needing avoidance of radiation (pregnant, childbearing age)  IVP: No longer favored due to lower sensitivity, HIGHER radiation exposure  KUB: Will miss radiolucent uric acid stones, small stones, stones with overlying bony structures.
  • 11. Urologic Intervention?  X<5mm : most pass spontaneously. Possible observation and pain control  X>5mm : less than 20% chance of passage and may need urologic intervention So when to consult urology?  If > 5mm  For ANY size with ….  Urosepsis, AKI, anuria, unyielding N/V/Pain -> Inpatient consult  Failed conservative management and stone did not pass spontaneously -> Inpatient or Outpatient consult depending on severity
  • 12.
  • 13.  Identified common risk factors for renal stone disease  Identified common signs and symptoms for renal stone disease  Know the common types of renal stones  Familiarized with basics of renal stone management, including knowing when to consult urology

Editor's Notes

  1. The answer is D. The rationale will be explained toward the end of the lecture
  2. On the last point, emphasize that the vast majority of first incidence of renal stones can be prevented by dietary changes, while the vast majority of recurrence can be prevented with dietary changes with appropriate medications.
  3. Pre-disposing medical factors, such as hyperparathyroidism, are a complex list, and will not be addressed here
  4. In the case of renal stone disease, typical symptoms are very typical. Of these, hematuria has very high sensitivity.
  5. Explanation for the bullet points Renal Cell carcinoma: The bleeding can cause clots that lodge in ureter to produce colic Ectopic pregnancy: vaginal bleeding mistaken for hematuria
  6. Urinalysis plays a significant role in narrowing the differential to renal stones. Metabolic workup that often requires 24 hour urine collection, should only be considered the patient has an established diagnosis of recurrent renal stones, and should only be pursued after the acute phase of the episode has passed. This is because during the acute phase, patients are often over/under hydrated, are on unusual (for the patient) medications or diet. The metabolic workup can consist of: Ruling out hyperparathyroidism, distal RTA, hyperoxaluria, excessive vitamin D, gout, chronic diarrhea, osteoporosis.
  7. In the vast majority of cases, Non-contrast CT should be used to establish the diagnosis. Emphasize that contrast is NOT recommended. Also, Ureteral dilation withOUT a stone present on imaging may represent the recent passage of one.
  8. Algorhythm on the following page