2. Identify common risk factors for renal stone
disease
Identify common signs and symptoms for
renal stone disease
Know the common types of renal stones
Familiarize with basics of renal stone
management, including knowing when to
consult urology
3. 49 year old woman with history of
hypertension, diabetes presents with four
day history of right sided flank pain and
“pink urine.” What is the most appropriate
imaging to diagnose this patient with renal
stone disease?
A: KUB
B: Ultrasound
C: Contrast-enhanced CT
D: Non-Contrast CT
4. Supersaturation of urine with solutes
Solubility is affected by urine pH, volume
and total excretion
Those factors can often be modified with
medications and diet
5. Male sex
Obesity
Family History
H/o stone disease (1/2 will have recurrence)
Dietary factors
Lower fluid intake, higher animal protein, higher
Vitamin C
Medical factors
6. Typical symptoms
Sudden onset
Unilateral colicky flank pain radiating to groin
(localization of pain evolves as stone migrates)
Often with nausea/vomiting
Hematuria (microscopic or gross)
7. Differential for flank pain with hematuria
UTI
Renal Cell Carcinoma
Ectopic pregnancy
Dissecting AAA with renal artery involvement
8. In order of prevalence
Calcium Oxalate
Calcium Phosphate
Struvite
Urice Acid
Cystine
9. Urinalysis: may show
Hematuria (90% sensitive)
Signs of infection
Crystals
Elevated pH (urea-splitting bugs?) or low pH
(RTA?)
Metabolic workup: Consider only if recurrent
10. Imaging
Non-Contrast helical CT with Stone protocol is
the gold std (can detect stones not visible by
KUB/IVP and has significantly better
sensitivity/specificity)
Ultrasound: For patients needing avoidance of
radiation (pregnant, childbearing age)
IVP: No longer favored due to lower sensitivity,
HIGHER radiation exposure
KUB: Will miss radiolucent uric acid stones, small
stones, stones with overlying bony structures.
11. Urologic Intervention?
X<5mm : most pass spontaneously. Possible
observation and pain control
X>5mm : less than 20% chance of passage and
may need urologic intervention
So when to consult urology?
If > 5mm
For ANY size with ….
Urosepsis, AKI, anuria, unyielding N/V/Pain ->
Inpatient consult
Failed conservative management and stone did not
pass spontaneously -> Inpatient or Outpatient consult
depending on severity
12.
13. Identified common risk factors for renal
stone disease
Identified common signs and symptoms for
renal stone disease
Know the common types of renal stones
Familiarized with basics of renal stone
management, including knowing when to
consult urology
Editor's Notes
The answer is D. The rationale will be explained toward the end of the lecture
On the last point, emphasize that the vast majority of first incidence of renal stones can be prevented by dietary changes, while the vast majority of recurrence can be prevented with dietary changes with appropriate medications.
Pre-disposing medical factors, such as hyperparathyroidism, are a complex list, and will not be addressed here
In the case of renal stone disease, typical symptoms are very typical. Of these, hematuria has very high sensitivity.
Explanation for the bullet points
Renal Cell carcinoma: The bleeding can cause clots that lodge in ureter to produce colic
Ectopic pregnancy: vaginal bleeding mistaken for hematuria
Urinalysis plays a significant role in narrowing the differential to renal stones.
Metabolic workup that often requires 24 hour urine collection, should only be considered the patient has an established diagnosis of recurrent renal stones, and should only be pursued after the acute phase of the episode has passed. This is because during the acute phase, patients are often over/under hydrated, are on unusual (for the patient) medications or diet.
The metabolic workup can consist of:
Ruling out hyperparathyroidism, distal RTA, hyperoxaluria, excessive vitamin D, gout, chronic diarrhea, osteoporosis.
In the vast majority of cases, Non-contrast CT should be used to establish the diagnosis.
Emphasize that contrast is NOT recommended.
Also, Ureteral dilation withOUT a stone present on imaging may represent the recent passage of one.