This meta-analysis provides data on dietary intake of main macronutrients/foods and their role in the development of infammatory bowel diseases (Hou et al. 2011)

1. www.pronutritionist.net
Dietary intake and risk of
developing inflammatory bowel
disease: a systematic review of
the literature
Hou JK et al.
Am J Gastroenterol 2011;106:563-573
Page 1 Hou JK et al. Am J Gastroenterol 2011;106:563-573.

2. Page 2
Background
• The incidence of inflammatory bowel disease (IBD) is increasing
• Etiology of IBD is not fully understood, but many factors may
influence such as genetics and environmental factors
• The association between diet and IBD
risk has not been clearly demonstrated
Hou JK et al. Am J Gastroenterol 2011;106:563-573. www.pronutritionist.net

3. Methods
• A systematic review of
– fully published case-control and cohort studies of the
association between pre-illness diet and IBD risk
• 19 studies were included
– 18 case-control studies, 1 cohort study
– 2 609 IBD patients
• 1 269 Crohn’s disease (CD)
• 1 340 ulcerative colitis (UC)
• > 4 000 controls
Page 3 Hou JK et al. Am J Gastroenterol 2011;106:563-573. www.pronutritionist.net

4. Results (1/3): dietary intake and Crohn’s
Disease risk
Page 4 Hou JK et al. Am J Gastroenterol 2011;106:563-573. www.pronutritionist.net

5. Results (2/3): dietary intake and Colitis
Ulcerosa risk
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6. Results (3/3)
• No consistent associations between total
carbohydrate intake and IBD were observed
www.pronutritionist.netHou JK et al. Am J Gastroenterol 2011;106:563-573.Page 6

7. Discussion
• This was the first systematic review on diet and incidence
of IBD
• Currently recommended high intake of PUFA, especially
omega-6 fatty acids, may increase the risk of IBD
disease
• High intake of fiber, vegetables and fruit seems to be
protective against IBD
• Meat consistently increased the risk of IBD, whereas
other protein sources (fish, eggs, dairy) had no effect
• Biggest shortfall of this meta-analysis is its retrospective
nature
• More randomized studies are urgently needed as the
prevalence of IBD increases worldwide
Page 7 Hou JK et al. Am J Gastroenterol 2011;106:563-573. www.pronutritionist.net