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Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
Dna replication, repair, recombination
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Dna replication, repair, recombination

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Transcript

  • 1. Cell & MolecularBiology
  • 2. DNA Replication,Repair andRecombination
  • 3. Chapter 6
  • 4. DNA Replication
  • 5. Three models ofDNA replication
  • 6. Figure 6-6 Essential Cell Biology (© Garland Science 2010)
  • 7. Each strand of DNAin a double helixserves as a template
  • 8. Base Pairingis at the heartof DNA replication
  • 9. Figure 6-4 Essential Cell Biology (© Garland Science 2010)
  • 10. Replication Origins
  • 11. “...positions at which the DNAis first opened up... usually markedby a particular sequence ofnucleotides.”
  • 12. Figure 6-5 Essential Cell Biology (© Garland Science 2010)
  • 13. Replication Forks
  • 14. Figure 6-9 Essential Cell Biology (© Garland Science 2010)
  • 15. DNA replicationis bidirectional
  • 16. DNA issynthesized5’ to 3’
  • 17. Figure 6-10 Essential Cell Biology (© Garland Science 2010)
  • 18. Figure 6-11 Essential Cell Biology (© Garland Science 2010)
  • 19. Leading andlagging strands
  • 20. Figure 6-12 Essential Cell Biology (© Garland Science 2010)
  • 21. DNA Polymerase
  • 22. Accuracy
  • 23. Nucleotide addition is catalyzedonly when base-pairing is correct.
  • 24. Figure 6-13 Essential Cell Biology (© Garland Science 2010)
  • 25. Proofreading clips outadded nucleotides thatdo not correctly base-pair.
  • 26. Figure 6-14 Essential Cell Biology (© Garland Science 2010)
  • 27. For proofreading to work,DNA must be synthesizedfrom 5’ to 3’.
  • 28. Figure 6-15 Essential Cell Biology (© Garland Science 2010)
  • 29. DNA polymerase canonly add nucleotides toa base-paired nucleotidein a DNA double helix.
  • 30. So the synthesis of DNAbegins with RNA primers.
  • 31. Figure 6-17a Essential Cell Biology (© Garland Science 2010)
  • 32. Figure 6-16 Essential Cell Biology (© Garland Science 2010)
  • 33. Figure 6-17a Essential Cell Biology (© Garland Science 2010)
  • 34. Figure 6-17b Essential Cell Biology (© Garland Science 2010)
  • 35. The Replication Machine
  • 36. Helicase
  • 37. Single-Strand Binding Protein
  • 38. Sliding Clamp
  • 39. Clamp Loader
  • 40. DNA Primase
  • 41. Telomerase
  • 42. Figure 6-17b Essential Cell Biology (© Garland Science 2010)
  • 43. Figure 6-18 Essential Cell Biology (© Garland Science 2010)
  • 44. DNA Repair
  • 45. Replication Errors
  • 46. Figure 6-21a Essential Cell Biology (© Garland Science 2010)
  • 47. Figure 6-21b Essential Cell Biology (© Garland Science 2010)
  • 48. Figure 6-21c Essential Cell Biology (© Garland Science 2010)
  • 49. Mismatch Repair
  • 50. Figure 6-22 Essential Cell Biology (© Garland Science 2010)
  • 51. DNA Damage
  • 52. DepurinationDeamination
  • 53. Figure 6-23 Essential Cell Biology (© Garland Science 2010)
  • 54. Figure 6-25a Essential Cell Biology (© Garland Science 2010)
  • 55. Figure 6-25b Essential Cell Biology (© Garland Science 2010)
  • 56. ThymineDimerization
  • 57. Figure 6-24 Essential Cell Biology (© Garland Science 2010)
  • 58. Repair:1. excision2. resynthesis3. ligation
  • 59. Figure 6-26 Essential Cell Biology (© Garland Science 2010)
  • 60. Double-Stranded Breaks
  • 61. NonhomologousEnd-Joining
  • 62. Figure 6-27 Essential Cell Biology (© Garland Science 2010)
  • 63. HomologousRecombination
  • 64. “...the exchange ofgenetic informationbetween a pair ofhomologous DNA molecules...”
  • 65. Double-strandedbreak repair
  • 66. Figure 6-31 (part 1 of 2) Essential Cell Biology (© Garland Science 2010)
  • 67. Figure 6-31 (part 2 of 2) Essential Cell Biology (© Garland Science 2010)
  • 68. Meiosis
  • 69. Page 183
  • 70. Figure 6-30 Essential Cell Biology (© Garland Science 2010)
  • 71. Figure 6-31 (part 1 of 2) Essential Cell Biology (© Garland Science 2010)
  • 72. Figure 6-31 (part 2 of 2) Essential Cell Biology (© Garland Science 2010)
  • 73. MobileGeneticElements
  • 74. or,Transposons
  • 75. DNA-Only Transposons
  • 76. 3 Bacterial TransposonsFigure 6-32 Essential Cell Biology (© Garland Science 2010)
  • 77. Transposase
  • 78. Figure 6-33 Essential Cell Biology (© Garland Science 2010)
  • 79. Retrotransposons
  • 80. Figure 6-34 Essential Cell Biology (© Garland Science 2010)
  • 81. Reverse Transcriptase

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