There are 11 major body systems that work together to maintain homeostasis: 1. The nervous system controls and coordinates functions throughout the body and responds to stimuli. 2. The skeletal system supports the body, protects organs, allows movement, and stores minerals. 3. The muscular system works with the skeletal system to produce movement and circulate blood. 4. The integumentary system acts as a barrier against infection/injury and regulates temperature.