Proteobacteria are major phylum of gram negative bacteria. Major groups of Proteobacteria with medical importance: Medically important genus Rickettsia which causes typhus, Rocky Mountain spotted fever, Flinders Island spotted fever, rickettsialpox, Boutonneuse fever, African tick bite feverQueensland tick typhus. They are transmitted by arthropod including tick, flea and lice. Two species of Neisseria causes diseses-N. meningitidis and N. gonorrhoeae (sexually transmitted) Three species of Bordetella are human pathogen - B. pertussis (causes whooping cough- air borne infection), B. parapertussis, B. bronchiseptica Some serotypes of Escherichia coli are human pathogens and cause urinary tract infections, significant sources of gastrointestinal disease, ranging from simple diarrhea to dysentery-like conditions Shigella-S. dysenteriae cause dysentry (Shigella infection is typically by ingestion) Salmonella-Salmonella typhi cause typhoid fever. Other species of Salmonella causes food poisoning Yersinia -Y. pestis is the causative agent of the plague Haemophilus -H. influenzae causes sepsis and bacterial meningitis in young children and H. ducreyi, the causative agent of chancroid Vibrio- V. cholerae (causative agent of cholera) is generally transmitted by contaminated water. Pseudomonas are opportunistic pathogen Helicobacter,H. pylori is strongly associated with peptic ulcers, chronic gastritis, duodenitis, and stomach cancer Solution Proteobacteria are major phylum of gram negative bacteria. Major groups of Proteobacteria with medical importance: Medically important genus Rickettsia which causes typhus, Rocky Mountain spotted fever, Flinders Island spotted fever, rickettsialpox, Boutonneuse fever, African tick bite feverQueensland tick typhus. They are transmitted by arthropod including tick, flea and lice. Two species of Neisseria causes diseses-N. meningitidis and N. gonorrhoeae (sexually transmitted) Three species of Bordetella are human pathogen - B. pertussis (causes whooping cough- air borne infection), B. parapertussis, B. bronchiseptica Some serotypes of Escherichia coli are human pathogens and cause urinary tract infections, significant sources of gastrointestinal disease, ranging from simple diarrhea to dysentery-like conditions Shigella-S. dysenteriae cause dysentry (Shigella infection is typically by ingestion) Salmonella-Salmonella typhi cause typhoid fever. Other species of Salmonella causes food poisoning Yersinia -Y. pestis is the causative agent of the plague Haemophilus -H. influenzae causes sepsis and bacterial meningitis in young children and H. ducreyi, the causative agent of chancroid Vibrio- V. cholerae (causative agent of cholera) is generally transmitted by contaminated water. Pseudomonas are opportunistic pathogen Helicobacter,H. pylori is strongly associated with peptic ulcers, chronic gastritis, duodenitis, and stomach cancer.