Dr. Gaurav Gupta - Should you be buying an E-bike this Diwali?
Dr RP Bansal- Feeding difficulties in the newborn
Dr Nivedita- Tips on how to Continue Breast Feeding
Dr Ridhi- Teething tips
Dr Arushi - First afebrile seizure
Dr Amit - Mesentric lymphadenopathy
Dr Gunjan - Acute events following immunization plus update on BCG adenitis
Dr Sandip Jain- Tips for examining children
Dr Diljot - Mefenemic acid as an antipyretic
Dr Jaskaran- colicky infant : knowledge , attitude and practices
Dr Shailesh - School se chutti kitne din karayein ?
Dr Gaurav- Is it oral Herpes? Visual Quiz
Information to help women prepare for natural childbirht by physical theraist and educator Suzanne Tucker, contributing author to www.MyMommyManual.com as Zen Mommy.
This topic was presented by me in Neonatal Nursing Workshop in GUJNEOCON' 14. This presentation highlights some issues in the management of extremely low birth weight babies (<1000gm) from Nursing care point of view. Transport, Aseptic precautions, feeding issues are important aspects of cere which are not discussed here because were discussed by others. I had mainly focused on delivery room management, temperature and humidity maintenance, skin care and develpmental care because these are important aspects of ELBW care but often neglected.
Information to help women prepare for natural childbirht by physical theraist and educator Suzanne Tucker, contributing author to www.MyMommyManual.com as Zen Mommy.
This topic was presented by me in Neonatal Nursing Workshop in GUJNEOCON' 14. This presentation highlights some issues in the management of extremely low birth weight babies (<1000gm) from Nursing care point of view. Transport, Aseptic precautions, feeding issues are important aspects of cere which are not discussed here because were discussed by others. I had mainly focused on delivery room management, temperature and humidity maintenance, skin care and develpmental care because these are important aspects of ELBW care but often neglected.
Best Ever Guide Shared by Rosa Belinda Sanchez About Importance of Antenatal ...Rosa Belinda Sanchez
Rosa Belinda Sanchez Shared a detailed presentation on importance of antenatal care. This will defiantly help you. If you have any other queries related antenatal care do share in comment section. Find Rosa Belinda Sanchez at https://www.crunchbase.com/organization/rosa-belinda-sanchez-mother-children-care-specialists
This power-point includes content on brief introduction and classification & management of pneumonia based on Integrated Management of Neonatal & Childhood Illness (IMNCI).
When it comes to good positions to use while breastfeeding, your comfort as well as the ease with which your baby will be able to feed is the first and foremost concern. Finding a position that you are most comfortable and happy with will make it easier for your baby to latch on to your breasts and feed with ease. Here are some of the best breast-feeding positions that you might use when you are breastfeeding.
Explains about the importance of diet in Ayurveda and in special the postnatal herbal diet which makes the women to slim down after parturition and prevent the common puerperal
complaints.
3rd year MBBS UG class on postnatal care of mother and newborn baby including intranatal and postnatal advice, domiciliary care,warning signs, APGAR score and many more with video clips.
Best Ever Guide Shared by Rosa Belinda Sanchez About Importance of Antenatal ...Rosa Belinda Sanchez
Rosa Belinda Sanchez Shared a detailed presentation on importance of antenatal care. This will defiantly help you. If you have any other queries related antenatal care do share in comment section. Find Rosa Belinda Sanchez at https://www.crunchbase.com/organization/rosa-belinda-sanchez-mother-children-care-specialists
This power-point includes content on brief introduction and classification & management of pneumonia based on Integrated Management of Neonatal & Childhood Illness (IMNCI).
When it comes to good positions to use while breastfeeding, your comfort as well as the ease with which your baby will be able to feed is the first and foremost concern. Finding a position that you are most comfortable and happy with will make it easier for your baby to latch on to your breasts and feed with ease. Here are some of the best breast-feeding positions that you might use when you are breastfeeding.
Explains about the importance of diet in Ayurveda and in special the postnatal herbal diet which makes the women to slim down after parturition and prevent the common puerperal
complaints.
3rd year MBBS UG class on postnatal care of mother and newborn baby including intranatal and postnatal advice, domiciliary care,warning signs, APGAR score and many more with video clips.
constipation in children , pediatric constipation , management of constipation in children , understanding constipation , causes of constipation in children , functional constipation in children , treatment of constipation ,approach to constipation in children ,constipation in infants
Babies should be breastfed and/or receive expressed human milk exclusively for the first six months of life. Breastfeeding should continue with the addition of complementary foods throughout the second half of the first year.
Impact of Social Media on Mental Health.pptxGaurav Gupta
## Social Media: The Ups and Downs for Young Minds
**Uncover the impact of social media on children's mental health.**
This presentation explores the complex relationship between social media and the developing minds of children. We'll delve into:
* **The positive connections:** How social media fosters friendships, self-expression, and access to information.
* **The potential pitfalls:** Increased anxiety, depression, body image issues, and cyberbullying.
* **Strategies for healthy use:** Explore practical tips for parents and educators to promote safe and balanced social media habits in children.
**Equip yourself with the knowledge to guide young people in navigating the social media landscape.**
Good evening everyone, and thank you for joining me today. Today we’ll be exploring the impact of social media on the mental health of children and adolescents. Social media is an undeniable part of our lives, and pediatricians are in a unique position to guide parents and children in navigating this digital landscape.
How AI will transform Pediatric Practice - Feb 2024Gaurav Gupta
Creating a concise and compelling summary for a SlideShare presentation on "How AI Will Transform Pediatric Practice" involves highlighting key points that emphasize AI's potential benefits, challenges, and future implications in pediatric healthcare. Here's a structured summary that could be effectively used in your SlideShare:
---
**Title: Transforming Pediatric Practice: The Role of AI**
**Introduction:**
- Briefly introduce the current state of pediatric practice, emphasizing the importance of accurate diagnosis, personalized treatment, and efficient healthcare delivery.
- Introduce Artificial Intelligence (AI) as a transformative tool in medicine, with a focus on pediatrics.
**AI's Impact on Diagnostics:**
- Highlight how AI algorithms enhance diagnostic accuracy in pediatric care, enabling early detection of diseases through pattern recognition in imaging, genomics, and clinical data.
- Discuss case studies where AI has successfully identified pediatric conditions earlier and more accurately than traditional methods.
**Personalized Treatment Plans:**
- Explain how AI contributes to the development of personalized medicine in pediatrics, considering the unique genetic, environmental, and lifestyle factors of each child.
- Provide examples of AI systems recommending customized treatment protocols and monitoring disease progression in real-time.
**Operational Efficiency and Patient Care:**
- Illustrate AI's role in streamlining administrative tasks, scheduling, and patient flow, allowing healthcare professionals to focus more on patient care.
- Discuss AI-powered virtual health assistants and chatbots that provide 24/7 support and guidance to caregivers, answering questions and offering advice based on medical guidelines.
**Challenges and Ethical Considerations:**
- Address the challenges of integrating AI into pediatric practice, including data privacy, ethical considerations, and the need for robust training data.
- Discuss the importance of balancing AI tools with human oversight to ensure compassionate and empathetic patient care.
**The Future of AI in Pediatrics:**
- Envision a future where AI not only supports clinical decision-making but also predicts health outcomes, identifies potential public health crises, and contributes to global pediatric health research.
- Highlight the importance of interdisciplinary collaboration in developing AI tools that are ethical, equitable, and truly beneficial for child health.
**Conclusion:**
- Summarize the transformative potential of AI in pediatric practice, emphasizing its role in enhancing healthcare delivery, improving patient outcomes, and paving the way for innovative treatment approaches.
- Call to action for healthcare professionals, researchers, and technologists to collaborate in harnessing the power of AI for the betterment of pediatric healthcare.
Latest GINA guidelines for Asthma & COVIDGaurav Gupta
What are the changes from 2019 onwards till 2022, in the GINA guidelines for developing countries like India.
Includes COVID guidelines and also a FUN QUIZ !
Talk about why these guidelines have changed - use of ICS - formoterol combination for treating even intermittent asthma
Dr Naveen Kini, Pediatrician from Bengaluru talks about WHAT is podcasting, HOW we can listen to podcasts, WHY doctors should create podcasts and much more. Co-hosted with Dr Gaurav Gupta. In arrangement with dIAP and CMIC. This is PART 1 - we discuss how to create a simple free & easy podcast in part 2 - check the presentation on slideshare under my account
Podcast creation for doctors (Pediatricians)Gaurav Gupta
What are podcasts, why should doctors listen to podcasts, how can doctors create a podcast. With Dr Naveen Kini - as a part of CMIC initiative, this program was broadcast on dIAP network on 15th July 2021, This is part 2 of the presentation by me. I talk about HOW to create a podcast easily and for free using the Anchor.fm app
Hep a Live & Inactivated vaccines in IndiaGaurav Gupta
dIAP presentation for GSK - Havrix and comparison of Live and inactivated Hepatitis A vaccines in Dec 2020.. Online discussion about the various Hep A vaccines available and their pros and cons
Prevention of influenza in relation to COVID 19 - the TWINDEMICGaurav Gupta
What is the concern about the TWINDEMIC of COVID 19 & Influenza?
My talk on the digital IAP platform in Dec 2020 for the pediatricians across the country
Top 10 practical questions about Flu Vaccine in India!Gaurav Gupta
What does a practising paediatrician want to to know about the Flu vaccination? Talk for Abbott Vaccines (Influvac Tetra) in Oct 2020 about common queries that doctors have about the flu vaccine in India, including how it may help in COVID-19?
Helping doctors avoid COVID in their Office PracticeGaurav Gupta
Tips for doctors and their patients to avoid Coronavirus during OPD practice in India. From a Pediatrician's perspective. How can we take supplements prophylactic medicines like Vit D, Vit C, Zinc, etc. and medicines like HCQ or Ivermectin to prevent COVID during seeing patients in our practice.
Digital eye strain - Computer vision syndrome for students during Online clas...Gaurav Gupta
Dr. Poonam Gupta, Eye Specialist from Charak Clinics, Mohali, talks with Aakash Institute about Computer vision syndrome, Digital Vision Syndrome, Eye fatigue in students doing online classes during the lockdown. How to prevent it and treat with with simple steps including the 20-20-20 rule etc.
Prevenar e cme june 2020 & FAQs & COVID Clinic QuestionsGaurav Gupta
Lockdown E-CME & Webinars - this one is on Pfizer vaccine - Prevenar,
We have also discussed the common questions on Pneumonia & how to run clinical practice during COVID shutdown
Digital waste management pedicon 2020 Indore, preconference workshopGaurav Gupta
What is important and relevant about Digital waste management pedicon 2020 Indore, preconference workshop. How to dispose of your printers, computers, mobile phones, relevant to India
How to Advertise yourself with simple office tools PEDICON 2020 Indore workshop 8 jan, 2020. How to use whatsapp, blogs, youtube facebook to advertise yourself online
Zyvac TCV - The Indian Typhoid Conjugate VaccineGaurav Gupta
Presented at Ambala in Jan 2020. Is TCV needed, and is it better than Polysaccharide vaccine. Indian data and studies by Dr. Gaurav Gupta, Pediatrician from Charak Clinics, Mohali
At the four front of flu vaccination - Quadrivalent Flu Vaccination in India ...Gaurav Gupta
Is flu vaccination needed in India? Is there any benefits of Quadrivalent Flu vaccination over Trivalent Flu vaccination? Any safety & efficacy data about Vaxiflu 4 by Zydus Vaccines. All discussed in a Presentation in Panchkula, in September 2019
Meningococcal disease sep 2019 National Epidemiology & Indian recommendationsGaurav Gupta
IAP tricity Panel Discussion on Need for Meningococcal Vaccination, Panel discussion featuring Professors from PGIMER Chandigarh Pediatrics Dept, Microbiology Department
Japanese encephalitis - Sep 2019 India epidemiology - Is vaccination needed?Gaurav Gupta
IAP Chandigarh Meeting presentation on a Panel Discussion on the need for JE vaccination in Indian situation, especially for private practitioners in and around Chandigarh, North India
Research in pediatrician office - my story! NORC Aug 2019 New DelhiGaurav Gupta
Presented in NORC - Aug 2019 - National Original Research convention, discussion of Flu like illnesses and the Flu vaccination and drug utilization reviews and prescription audits and various other original research presented and published by Dr. Gaurav Gupta in his years of clinical practice, including yellow fever, Complementary medicines, drug costs and prescriptions analysis
What nelson forgot 4 - Super CME for Common Pediatric OPD questionsGaurav Gupta
What nelson forgot 4 - Super CME for Common Pediatric OPD questions, 12th July 2019
Common Office practice questions, answered in just 5-10 minutes per topic ...
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
2. Scope
• 10 questions,
• < 10 mins discussion per question
• Immediate diagnosis / treatment
• Minimum slides, Optional References
• START when 10 people are present after 830 PM, incl at least 1
speaker
• FINISH when a majority decides ….
3. Scope
• Please note that this initiative is to discuss common issues in
practice for which sometimes there are no concrete guidelines.
• It's an open forum to discuss personal experience, expertise
and knowledge with or without references.
4. Topics
• Dr. Gaurav Gupta - Should you be buying an E-bike this Diwali?
• Dr RP Bansal- Feeding difficulties in the newborn
• Dr Nivedita- Tips on how to Continue Breast Feeding
• Dr Ridhi- Teething tips
• Dr Arushi - First afebrile seizure
• Dr Amit - Mesentric lymphadenopathy
• Dr Gunjan - Acute events following immunization plus update on BCG adenitis
• Dr Sandip Jain- Tips for examining children
• Dr Diljot - Mefenemic acid as an antipyretic
• Dr Jaskaran- colicky infant : knowledge , attitude and practices
• Dr Shailesh - School se chutti kitne din karayein ?
• Dr Gaurav- Is it oral Herpes? Visual Quiz
5. Should you buy an E-bicycle
this Diwali?
Dr. Gaurav Gupta
6. What is an E-bike?
• Everything a normal cycle has…
including gears,
• Also has rechargeable batteries, a motor
(40 km to charge- 1 Unit, 5 hours to full
charge)
• And controllers
7. Market
Increasing worldwide
• 2 lakh (2008) 5 lakh (2009) 7 lakh
(2010) e-bikes sold in Europe
• China is world leader, (> 10 billion USD
sales)
• USA, India & Netherlands are some
upcoming countries
• The number of electric four wheeled
vehicles in circulation is around 4
million. But the number of electric
bikes in circulation is over 35 million.
8. E-cycles
Pros
The HEM Effect TM ?
• Health
• Environment
• Money
• Great for the ‘less fit’ – range
• Any pains/ aches
• ‘No sweat’ commute to clinic
• FUN FUN FUN !
Cons
• Early Adopter technology
• Increased maintenance
• Expensive, heavy
9. Call to action
It’s FUN!
Freedom!
Save the Environment!
Looks COOL!
Chandigarh is India’s
Cycling City
20. A physician managing a child following a first afebrile
seizure should try to answer five questions:
1. Was the episode an epileptic seizure?
2. What is the cause of the seizure?
3. What investigations should I do?
4. Does the child require treatment?
5. What else should I think about?
21. Red Flags
• Head injury with delayed seizure
• Developmental delay or regression
• Headache prior to the seizure
• Bleeding disorder, anticoagulation therapy
• Drug/alcohol use
• Focal signs
25. Poor initiation: improper latching
• Baby was born 3.5 kg, lost weight to 3.1 kg, regain was very slow;
she weighed almost same 3.5 kg on 18th day. Was EBF.
• The mother was overanxious, was feeding the baby very frequently
but wasn’t making proper contact. Baby used to suck vigorously but
she was not getting a good supply. The mother used to get
impatient soon, the baby was fussy all the time.
• The mother was asked to give ample time to the act of feeding, was
explained the ‘latching’, an occasional spoon feed was suggested
daily and was called after a week.
26. Cntd.
• The baby gained a good 300 Gm in the next 8 days.
• Never looked back.
• Spoon feed was stopped.
27. The milk on the back is better!
• Arnav was born 3.3 kg and brought for vaccination at 45 days. The
mother was not satisfied with his growth. He weighed 4.3kg, was
taking breast feed almost every hour, passing 15 semi loose stools
in 24 hours and was a cranky baby.
• On examination, he was having some perianal excoriations. On
asking, the mother told that she was giving EMB, fed the baby from
both breasts in one sitting.
• The mom was explained about the importance of hind milk and
asked to let one breast empty before offering the second one.
Called after 10 days.
28. Hind milk did wonders!
• The baby gained a good amount of weight,400 gms in 10 days.
Number of stools decreased to 5-6 a day, excoriations
disappeared, the baby started sleeping more peacefully.
• The mother was also sleeping more peacefully!
30. Why this discussion
Common scenerio in opd
Mother starts and wants to breastfeed according to advise received in
antenatal period and at discharge. Comes at 6 wk vaccination visit –Is
giving mixed bottle and BF and gradually over next visits we have an
exclusively bottle fed baby.
FACTS
95% indian mothers start breastfeed initially
Exclusively breastfed – 54%
Most of them quit in early wks due to
1) Perceived low milk supply
2) Family pressure
3) Find it difficult
31. How can we help- Tips
Breastfeeding guidance visit
◦ Around 3 wks after discharge
◦ Supervision of position (of mother too)
◦ May be difficult but why a must for baby
◦ GOOD LATCH IS THE KEY
Adequate drainage of breast
Foremilk, hindmilk
◦ Dedicated staff, written handouts,videos
32. Counseling of father and dadi-nani
◦ Pet nahi bharta ,Rota rehta hai
◦ Susu?.......... Mint mint mein
Focus On
Adequacy of breastmilk
(Weight gain, urine output)
Crying is normal for babies
Hunger cues
Dangers of bottle feeding
33. Low milk supply ?
◦ Adequate drainage of breasts
Position, latch
Increase time on breast
manual expression, breast pumps(sick baby)
◦ Self breast massage
◦ Relaxation, Diet, hydration
◦ Skin to skin, KMC
◦ Galactogouges
last resort
Not much research (level III evidence)
shortest possible time
38. • Gently rubbing the gums with a
Clean finger
Small cool spoon
Moist gauze pad
• Let baby chew on refrigerated vegetables like
carrots
• Use of teethers – solid rubber or silicon, can be
refrigerated. Avoid ones containing water.
• Use Paracetamol if pain or inflammation severe.
39. Not recommended
• Benzocaine or Lignocaine preparations or teething gels: risk of
seizures, methemoglobinemia
• Teething necklaces and bracelets: risk of strangulation and
choking
• Homeopathic preparations: contain Belladona, caffeine and
not safe for babies
41. A. Primary (Nonspecific) : MC Children < 15 years
• Acute
• Chronic/Recurrent
B. Secondary :
• Mesentric Nodes size (USG, Short axis view -AP) - I
• Isolated finding with no other obvious cause
• Group of nodes > 3 in number
• Children > 8 mm
• Adult > 5 mm
42. Symptoms
• Acute :
• Fever - MC
• Abdominal pain -
diffuse/periumblical > RLQ
• URI like symptoms - accompanying
or antecedent (20-30%)
• Nausea/Vomiting - precedes pain
• Loose stools : if prominent suspect
zoonotic infection (Yesinia/Non-
typhoidal salmonella)
• Chronic :
• Recurrent pain abdomen
43. Examination
• Local :
• Normal or mild diffuse tenderness
• RLQ tenderness +/- voluntary guarding or rebound
tenderness
• Systemic :
• Rhinorrhoea, Congested pharynx
• Cervical LAP - 20%
44. • Most common Differential Diagnosis :
• Acute: Acute Appendicitis ; Intussception
• Chronic :Giardia Lamblia, Tubercular
• Most cases - self limiting viral illness (MC - Adenovirus); 1- 4 weeks
• Linked to reduced risk for ulcerative colitis in adulthood
45. Diagnosis
• Diagnosis of exclusion : Pain
• Need to rule various important D/D - Constipation,
Appendictis, Intussception, Merckle diverticulum, IBD,
Cystitis/UTI, testicular torsion, ectopic pregnancy
• Yersinia enterocolitis/Salmonella - uncooked or undercooked
pork, tofu, unpasteurised milk/milk products contact with domestic
animal
46. Acute Appendicitis Mesenteric Adenitis
• Age older children
• Shorter history (1-2 days)
• Pain precedes vomiting
• Anorexia
• Guarding/Rigidity/Rebound
tenderness
• Usually absence of other localising
symptoms
• Leucocytosis - Neutrophilic; Higher
CRP values
• Age younger children
• Slighter longer (4-5 days);
recurrent
• Vomiting precedes pain
• Relatively preserved appetite
• Absence of
guarding/rigidity/rebound
tenderness
• Concomitant Viral URI/congested
pharynx
• Leucocytosis - lymphocytic
predominance; Lower CRP values
USG with graded compression
48. Treatment
• Chronic/Recurrent :
• Wait & Watch - repeat USG 1-3
months ; if persistent symptoms with
enlarged nodes - adenitis is not a
cause for the pain and look for other
etiologies or FAP
• Rule out TB
50. Case
• 6 week female, weight 4.8 kg.
• Birth weight 2.5 kg, no complications
• H/o URI 1 week back which had subsided by now
• Top feeds but accepting well and gaining weight.
• Vaccinated 40 hours back
• Came with decreased feeding from morning
• O/E - HR - 160/min RR - 75/min, SpO2 - 80% RA, SCR ICR +
• RBS - 90mg/dl
• Respiratory failure and referred
51. Vaccine Reactions
• Vaccine Product related
• Vaccine quality defect related reaction
• Immunization error related reaction
• Immunization anxiety related reaction
• Coincidental event
53. Severe reaction
• Usually do not result in long-term problems.
• Can be disabling.
• Are rarely life threatening.
• Seizure
• Allergic reactions
54. Serious Adverse Event
Any untoward medical occurrence that at any dose causes-
• Death
• Requires inpatient hospitalization or prolongation of
existing hospitalization
• Results in persistent or significant disability/incapacity
• Life-threatening.
55. Vaccine Reaction Onset Interval Frequency per doses
given
BCG Fatal dissemination of
BCG infction
1-12 months 0.19 - 1.56/ 1000000
OPV VAPP 4 - 30 days 2-4/1000000
DTP Prolonged crying and
seizures.
Hypotonic Hyporesponsive
episodes
0 - 24 hours <1/100
<1/1000 - 2/1000
Measles Febrile Seizures
Thrombocytopenia
Anaphylaxis
6-12 days
15-35 days
1 hour
1/3000
1/30000
1/100000
56. Fainting Anaphylaxis
Onset Immediately 5 - 30 min
Skin Pale sweaty cold clammy Red raised rashes
Respiratory normal to deep obstruction
HR Bradycardia tachycardia
GI nausea/vomiting abdominal cramps
CNS transient loss of conciousness no loss
60. What is sometimes done “ Myths”
• Start antibiotics
• Start ATT
• Start only INH
• Evaluate with Mantoux test and Xray chest
• I and D
• Excision
61.
62. Take Home Messages
• Vaccine related adverse event should be anticipated
• Prepared for immediate management in clinic
• Referred in time
• Reporting
• BCG adenitis - leave it alone
65. Knowledge :what we know
• Incidence :8-40%
• Multifactorial etiology
• Natural history
• Definitions :
– Wessels Criteria – “3”
– Classified as FGID under ROME III ->IV
66. Attitude
• Parents
Impending Catastrophe
Maternal depression
Naani/dadi ??
Gripe water
• Doctors
No EBM guidelines
Need to rule out organic causes
Need to find “Ram Baan ilaj”
67. Practices : what works & what doesn’t (evidence)
Intervention evidence Practically!
Semethicone Doesn’t work Most widely used
Dicyclomine Not recommended for <6
months age
Very often used
Cimetropium bromide Poor quality Often used
Probiotic (L.reuteri) Good evidence(metanaysis
of 6 rct’s)
Costly, not proven in non
breast fed babies
Gripe water Not recommended Suggested often by family
Lactase drops Small studies : positive
results
Seldom used
Fennel seeds preparation Good effectiveness, but
heterogenous studies
Grandparents favourite
Maternal diet Poor evidence May be tried , especially
with h/o atopy
Phyhsical maneuvers Poor evidence May be tried
Parental counselling Consistent results Gold standard !!
68. Thank you !
• Asking for your blessings and support for new venture :
2 bays SCF No 4, sector 20 C , Chandigarh
80. Herpetic Gingivostomatitis
• On “attached
gingiva” like gums &
hard palate,
• Also on lips &
tongue,
• Multiple small
blisters, raised edges
yellowish superficial
base
81. Aphthous Ulcer
• Deeper, Punched out, more in the
vestibule,
• Red borders
• Greyish base may coalesece,
• Unlikely on tongue unless traumatic