What is Simmonds’ disease aka pituitary cachexia? Describe the features of the disease
Solution
Answer: Simmonds\' disease or pitutary cachexia is a disease caused by the destruction of the
anterior lobe of the pitutary gland due to any cause, like post partum necrosis of the pitutary
gland, trauma like bullet injuries or fractures at the base of the skull, morbidities like tuberculosis
or syphilis, tumors of the pitutary and supra cellar cysts are some of the main caises of
Simmonds\' disease.
Features are:
1. as post-partum necrosis is one of the major causes of simonds\' disease, it is most common
betweeb ages of 20- 45 years. it is more common in women than men.
2. earliest manifestation of the disease are evident soon after few days from puerperium.
3. Failure of lactation or rather engorgement of the breasts is noticed.
4. Patients are of average nutrition and have a pale, dry, rather sallow skin suggesting a degree
of anemia more severe than what the hematological examinations reveal with a possible
subthyroid condition.
5. Progeria is unusual
6. Head hair is normal in size and texture.
7. eyebrows are thin.
8. disturbance in menstruation with amennorhia or scanty and irregular periods.
9. Loss of libido
10. atrophy of genetelia.
11. bear a striking resemblance to myxoedema. skin of face and arms is dry and scaly with a faint
yellow colouration.
12. senstivity to cold is pronounced.
13. well marked erythema ab igne of legs is pronounced..
14. adrenal lesions lead to loss of pubic and axillary hair.
15. Keplers\' Test for adrenal dysfunction is positive.
Treatment: Horone replacement therapy is the only available management so far..
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What is Simmonds’ disease aka pituitary cachexia Describe the featu.pdf
1. What is Simmonds’ disease aka pituitary cachexia? Describe the features of the disease
Solution
Answer: Simmonds' disease or pitutary cachexia is a disease caused by the destruction of the
anterior lobe of the pitutary gland due to any cause, like post partum necrosis of the pitutary
gland, trauma like bullet injuries or fractures at the base of the skull, morbidities like tuberculosis
or syphilis, tumors of the pitutary and supra cellar cysts are some of the main caises of
Simmonds' disease.
Features are:
1. as post-partum necrosis is one of the major causes of simonds' disease, it is most common
betweeb ages of 20- 45 years. it is more common in women than men.
2. earliest manifestation of the disease are evident soon after few days from puerperium.
3. Failure of lactation or rather engorgement of the breasts is noticed.
4. Patients are of average nutrition and have a pale, dry, rather sallow skin suggesting a degree
of anemia more severe than what the hematological examinations reveal with a possible
subthyroid condition.
5. Progeria is unusual
6. Head hair is normal in size and texture.
7. eyebrows are thin.
8. disturbance in menstruation with amennorhia or scanty and irregular periods.
9. Loss of libido
10. atrophy of genetelia.
11. bear a striking resemblance to myxoedema. skin of face and arms is dry and scaly with a faint
yellow colouration.
12. senstivity to cold is pronounced.
13. well marked erythema ab igne of legs is pronounced..
14. adrenal lesions lead to loss of pubic and axillary hair.
15. Keplers' Test for adrenal dysfunction is positive.
Treatment: Horone replacement therapy is the only available management so far.
