Briefly describe the phenomenon of exon shuffling and provide an example of this in living systems Solution exon shuffling is a molecular mechanism for the formation of new genes. in this process 2 or more exons are from different genes are brought together at a non-homologous site or there is a duplication in the exons forming new intron-exon structures. exon shuffling takes place by various processes such as transposon-mediated, cross over between gametes during sexual recombination or any inappropriate recombinations. living examples for exon shuffling are metazoans such as Homo sapiens have post- transcriptional exon shuffling, Drosophila with 39% of gene rearrangements. during evolution, 1-1 shuffling units were found in Trichoplax adhaerans and Nematostella vectensis..