All about Vitamin B5 in dogs

1. Vitamin B5 for
Your Dog

2. Hello!
I am Dr. Preethi Sudarshanie
Dassanayake (B.V.Sc., M.Sc., MBA)
Veterinary Surgeon from Sri Lanka.
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3. Vitamin B5
⬡ Is an essential, water-soluble vitamin.
⬡ Member of the vitamin B complex.
⬡ Also known as Pantothenic acid or
Pantothenate.
⬡ Commonly known as anti-stress vitamin.
⬡ Pantothenic means “From everywhere”
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4. Pantothenic acid
⬡ Pure pantothenic acid is a viscous yellow oil.
⬡ It is stable at neutral pH.
⬡ Easily destroyed by acid, alkali & heat.
⬡ Commercial supplements contain Calcium
Pantothenate.
⬡ It is a white, odorless & crystalline substance.
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Discovery;
Pantothenic acid
was discovered by
Dr. Roger J.
Williams in 1933.

6. Structure of
Pantothenic acid
Made up of Pantoic acid
combined with β- Alanine by
amide linkage.
IUPAC-3-[(2,4 dihydroxy-
3,3-dimethylbutanoyl)
amino] Propanoic acid.
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7. Absorption, transport & excretion
Digestion
Dietary pantothenic
acid mainly found in
foods as compound
of CoA, acyl-CoA
synthetase, or acyl-
carrier proteins.
In the intestinal
lumen all forms
hydrolyzed into
pantotenic acid.
Absorption
pantothenic acid
absorbtion takes
place by carrier
mediated transport
across the intestinal
mucosa.
Transport & excretion
Pantothenic acid
bound with red blood
cells & transport into
target tissues.
Fltered by renal
tubules.
During low intake,
actively reabsorb
from renal tubules.
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8. NRC (2006)
The Pantothenic acid
requirement for all
classes of dogs is 15 mg
per Kg of diet.
AAFCO (1992)
Recommends 10 mg
Pantothenic acid per Kg
of diet for all classes of
dogs.
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Requirements for Dogs

9. Functions
⬡ Is a constituent of two major co-enzymes.
⬡ They are Coenzyme A (CoA) & Acyl Carrier
Protein (ACP).
⬡ CoA found in all tissues.
⬡ It is highly important for tissue metabolism.
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10. Functions of Co-enzymes
⬡ Co-enzymes are essential for
carbohydrate, protein & fat metabolism.
⬡ Lipid synthesis.
⬡ Synthesis of neurotransmitter.
⬡ Synthesis of steroid hormones.
⬡ Synthesis of porphyrins and haemoglobin.
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11. Functions of CoA
⬡ It acts as carboxylic acid carrier.
⬡ CoA bounded carboxylic acids have
high potential & Known as “active”.
⬡ CoA combined with acetate forms
“active acetate”.
⬡ It undergoes further interactions.
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12. Functions of CoA
⬡ It combines with two-carbon fragments
(from carbohydrates, proteins & fats)
and forms acetyl-CoA.
⬡ It is the most important step in complete
metabolism of carbohydrates, proteins
& fats.
⬡ Then undergo TCA cycle.
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13. Acetyl-
CoA
Combine with choline and form
a neurotransmitter known as
acetyl choline.
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14. CoA with ACP
Act as carrier of acyl groups:
⬡ In fatty acids, cholesterol & other sterol
synthesis reactions.
⬡ Oxidation of fatty acids.
⬡ Biological acetylations.
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15. Heme biosynthesis
⬡ α-ketoglutaric acid converts to succinic
acid (in TCA Cycle).
⬡ Succinic acid combined with CoA and
forms active succinate.
⬡ Active succinate with glycine initiate
first step of heme biosynthesis.
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16. Consequences of Deficiency
⬡ Stunted growth
⬡ Lethargy
⬡ Fatty changes in liver
⬡ Tachypnea
⬡ gastritis
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17. Consequences of Deficiency
⬡ Enteritis
⬡ Intussusceptions
⬡ convulsions
⬡ Death
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Sources;
Broccoli
Cabbage, Fish
Sweet potatoes
Beans , Eggs
Lentils , Milk
Liver & Kidney

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Thanks!
Any questions?
You can find me at:
dassanayakepreethi@gmail.com

20. Credits
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⬡ Photographs by google image.
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