Cancer is the second leading cause of death globally, with approximately 9.6 million deaths in 2018. Lifestyle factors like tobacco use, poor diet, excessive alcohol consumption and lack of physical activity account for around 30% of cancer cases. Some of the best ways to reduce cancer risk include not smoking or using tobacco; maintaining a healthy body weight through diet and exercise; limiting alcohol intake; protecting skin from sun exposure; and following safety protocols in the workplace. Consuming a diet high in vegetables, fruits and whole grains while limiting processed and red meats can also help in cancer prevention. Public education on lifestyle changes and screening programs are important to curb the rising burden of cancer worldwide.