Visualizing the Past for the Present: A Summation of Interdisciplinary Digital Archaeological Research for the University of California, San Diego Graduate Student Association Award Ceremony
This document summarizes Ashley Richter's work using new technologies for cultural heritage visualization in archaeology. It discusses how Richter uses 3D scanning and modeling to capture archaeological sites, and develops virtual and augmented reality applications to disseminate findings. It also describes Richter's role establishing an undergraduate research program at UCSD's Center for Interdisciplinary Science, where students gain experience applying technologies like scanning, imaging, and 3D printing to archaeological investigations in both land and underwater contexts. The document envisions these techniques comprising a new interdisciplinary field of "cultural heritage diagnostics."
Digital History: Methods and Perspectives
(21 October, 4 and 9 November 2016)
A Block-Seminar of the Department of History and Civilization organized together with the EUI Library and the Historical Archives of the European Union
Conveners: Prof. Alexander Etkind and Dr. Serge Noiret
Towards Culturally Aware AI Systems - TSDH SymposiumMarieke van Erp
Towards Culturally Aware AI Systems
Presented 23 June 2021
Slide credits: Cultural AI team members Andrei Nesterov, Laura Hollink, Ryan Brate, Valentin Vogelmann + input and inspiration from all Cultural AI Colleagues
Biases in data can be both explicit and implicit. Explicitly, ‘The Dutch Seventeenth Century’ and ‘The Dutch Golden Age’ are pseudo-synonymous and refer to a particular era of Dutch history. Implicitly, the ‘Golden Age’ moniker is contested due to the fact that the geopolitical and economic expansion came with great costs, such as the slave trade. A simple two-word phrase can carry strong contestations, and entire research fields, such as post-colonial studies, are devoted to them. However, these sometimes subtle (and sometimes not so subtle) differences in voice are as yet not often represented well in AI systems.
In this talk, I will discuss how the Cultural AI Lab is working towards creating AI systems that are implicitly or explicitly aware of the subtle and subjective complexity of human culture. I will highlight the different research strands and activities that look at AI from different angles as well as how we engage with our user communities to create synergies between the technology and the daily practice of cultural heritage professionals.
The Human in Digital Humanities
Online Symposium, Tilburg School of Humanities & Digital Sciences
Tilburg University
https://www.digitalhumanitiestilburg.com/
Computationally Tracing Concepts Through Time and SpaceMarieke van Erp
Slides for HNR2020 Keynote presentation
Abstract:
Digitised sources are a treasure trove for scholars, but accessing the information contained in them is far from trivial. Due to scale, traditional methods are insufficient to analyse the big data coming from these sources. Hence, computational methods look to be the solution. Indeed, computational methods can be utilised to identify and model concepts in large digital datasets, however the nature of these datasets as well as that of humanities research questions requires caution. In particular, the ramifications of time and location on understanding concepts cannot be underestimated.
In this talk, Marieke will present ongoing work on computationally tracing concepts through time and across geography using language and semantic web technology. The work illustrates that seemingly simple concepts (e.g. sugar) prove to be much more complex than expected. We discuss the importance of semantics in helping not only to deal with this complexity but reify it so that it can be interrogated both computationally and via expert analysis.
Slides 5, 8, 11, 12, 15, 16, 17, 18, 19, 20 are based the presentation Tabea Tietz gave for the paper "Challenges of Knowledge Graph Evolution from an NLP Perspective" in the WHiSe Workshop @ ESWC 2020 (2 June 2020).
http://hnr2020.historicalnetworkresearch.org/
Digital History: Methods and Perspectives
(21 October, 4 and 9 November 2016)
A Block-Seminar of the Department of History and Civilization organized together with the EUI Library and the Historical Archives of the European Union
Conveners: Prof. Alexander Etkind and Dr. Serge Noiret
Towards Culturally Aware AI Systems - TSDH SymposiumMarieke van Erp
Towards Culturally Aware AI Systems
Presented 23 June 2021
Slide credits: Cultural AI team members Andrei Nesterov, Laura Hollink, Ryan Brate, Valentin Vogelmann + input and inspiration from all Cultural AI Colleagues
Biases in data can be both explicit and implicit. Explicitly, ‘The Dutch Seventeenth Century’ and ‘The Dutch Golden Age’ are pseudo-synonymous and refer to a particular era of Dutch history. Implicitly, the ‘Golden Age’ moniker is contested due to the fact that the geopolitical and economic expansion came with great costs, such as the slave trade. A simple two-word phrase can carry strong contestations, and entire research fields, such as post-colonial studies, are devoted to them. However, these sometimes subtle (and sometimes not so subtle) differences in voice are as yet not often represented well in AI systems.
In this talk, I will discuss how the Cultural AI Lab is working towards creating AI systems that are implicitly or explicitly aware of the subtle and subjective complexity of human culture. I will highlight the different research strands and activities that look at AI from different angles as well as how we engage with our user communities to create synergies between the technology and the daily practice of cultural heritage professionals.
The Human in Digital Humanities
Online Symposium, Tilburg School of Humanities & Digital Sciences
Tilburg University
https://www.digitalhumanitiestilburg.com/
Computationally Tracing Concepts Through Time and SpaceMarieke van Erp
Slides for HNR2020 Keynote presentation
Abstract:
Digitised sources are a treasure trove for scholars, but accessing the information contained in them is far from trivial. Due to scale, traditional methods are insufficient to analyse the big data coming from these sources. Hence, computational methods look to be the solution. Indeed, computational methods can be utilised to identify and model concepts in large digital datasets, however the nature of these datasets as well as that of humanities research questions requires caution. In particular, the ramifications of time and location on understanding concepts cannot be underestimated.
In this talk, Marieke will present ongoing work on computationally tracing concepts through time and across geography using language and semantic web technology. The work illustrates that seemingly simple concepts (e.g. sugar) prove to be much more complex than expected. We discuss the importance of semantics in helping not only to deal with this complexity but reify it so that it can be interrogated both computationally and via expert analysis.
Slides 5, 8, 11, 12, 15, 16, 17, 18, 19, 20 are based the presentation Tabea Tietz gave for the paper "Challenges of Knowledge Graph Evolution from an NLP Perspective" in the WHiSe Workshop @ ESWC 2020 (2 June 2020).
http://hnr2020.historicalnetworkresearch.org/
The Hitchhiker's Guide to the Future of Digital HumanitiesMarieke van Erp
Slides of my DHOxSS closing lecture
Oxford, 26 July 2019
Abstract
In the constellation of research fields, new configurations are continuously reshaping our ideas of what a field should be. This is particularly the case in the young field of digital humanities which, as David M. Berry noted, started with a focus on improving access to digital repositories and then moved to expanding the limits of archives to include born-digital materials as research objects. Both moves greatly impacted our research practice. However, I argue that we have only started scratching the surface of what digital methods can mean for humanities research.
In particular, as our methods and collaborations with other fields have matured, we can now start imagining new types of research questions that go beyond the sum of their ‘digital’ and ‘humanities’ parts -- to fundamentally change the nature of the humanities questions that we can ask. For such a reshaping to occur, we need to deepen the connection to our academic neighbours and keep looking beyond our own research community in order to ask these new questions. In my talk, I will present how multi-disciplinary collaborations between historians, linguists, and computer scientists can bring about new insights that may form the first steps to this future.
Project ‘The Digital City Revives’. A Case Study of Web ArchaeologyTjarda de Haan
Project ‘The Digital City Revives’. A Case Study of Web Archaeology - A sneak preview: DIY Handbook for Web Archaeology
Tjarda de Haan, web archaeologist & guest e-curator Amsterdam Museum
Heritage Studies: Preservation and Presentation of the Moving Image
University of Amsterdam, 20 April 2017
Marieke van Erp & Victor de Boer (2021, June). A Polyvocal and Contextualised Semantic Web. In European Semantic Web Conference (pp. 506-512). Springer, Cham.
Presented on 8 June, 2021
Design challenges, content and tools for cultural heritageISMB
A personal stream of consciousness in 60 slides: from Physical to Digital and beyond, encompassing themes like culture dualisms, value chains and workflows, challenges, opportunities and other topics, to suggest a rich design space.
The Social Digitization Workshop of the Silesian Digital Library at the Siles...Śląska Biblioteka Cyfrowa
Presentation given at the third European Congress on E-Inclusion ‘Transforming Access to Digital Europe in Public Libraries’ (ECEI11), European Parliament, Brussels
Project "The Digital City Revives, A Case Study of Web Archaeology"Tjarda de Haan
Presentation at the iPRES 2016, 13th International Conference on Digital Preservation. Bern, October 3-6, 2016
By Tjarda de Haan, guest e-curator & web archaeologist at the Amsterdam Museum
Partners:
National Coalition Digital Preservation, Netherlands Institute for Sound and Vision, Old inhabitants, (ex) DDS employees and DDS affiliated web-archeologists, UvA Faculty of Science and Waag Society
Visit:
http://www.dpconline.org/newsroom/latest-news/1777-qthe-digital-city-revivesq-a-case-study-of-web-archaeology
http://hart.amsterdammuseum.nl/re-dds
http://www.bitsandbytesunited.com/?portfolio=publication-the-reconstruction-of-the-digital-city-a-case-study-of-web-archaeology
Digital Cultural Heritage and the new EU Framework Programmelocloud
2nd LoCloud CY Awareness Event at the Ministry of Education and Culture.
Presentation delivered by Marinos Ioannides, Cyprus University of Technology
Cyprus
5 March 2014
Definitions, issues and debates in the Digital Humanities.
• What are Digital Humanities centres? Are there new ones? For
example at Princeton!
• And organizations like HASTAC and http://www.artshumanities.
net.
• DIGHUMLAB draft mission and goals.
• European organizations, DARIAH, CLARIN, NeDiMAH, etc..
• Some famous and useful case studies, tools and methods
• Education opportunities.
• Getting started in DH..
Digital Humanities is a term that elicits both excitement and scorn in scholarly circles, and there is still a great deal of discussion as to whether it is a field of inquiry, a set of research methods, or simply a new perspective on arts and humanities research. This workshop will provide a brief survey of how the evolving theory and practice of using contemporary technology and technology-assisted research methods are impacting scholarship in the arts and humanities.
The Hitchhiker's Guide to the Future of Digital HumanitiesMarieke van Erp
Slides of my DHOxSS closing lecture
Oxford, 26 July 2019
Abstract
In the constellation of research fields, new configurations are continuously reshaping our ideas of what a field should be. This is particularly the case in the young field of digital humanities which, as David M. Berry noted, started with a focus on improving access to digital repositories and then moved to expanding the limits of archives to include born-digital materials as research objects. Both moves greatly impacted our research practice. However, I argue that we have only started scratching the surface of what digital methods can mean for humanities research.
In particular, as our methods and collaborations with other fields have matured, we can now start imagining new types of research questions that go beyond the sum of their ‘digital’ and ‘humanities’ parts -- to fundamentally change the nature of the humanities questions that we can ask. For such a reshaping to occur, we need to deepen the connection to our academic neighbours and keep looking beyond our own research community in order to ask these new questions. In my talk, I will present how multi-disciplinary collaborations between historians, linguists, and computer scientists can bring about new insights that may form the first steps to this future.
Project ‘The Digital City Revives’. A Case Study of Web ArchaeologyTjarda de Haan
Project ‘The Digital City Revives’. A Case Study of Web Archaeology - A sneak preview: DIY Handbook for Web Archaeology
Tjarda de Haan, web archaeologist & guest e-curator Amsterdam Museum
Heritage Studies: Preservation and Presentation of the Moving Image
University of Amsterdam, 20 April 2017
Marieke van Erp & Victor de Boer (2021, June). A Polyvocal and Contextualised Semantic Web. In European Semantic Web Conference (pp. 506-512). Springer, Cham.
Presented on 8 June, 2021
Design challenges, content and tools for cultural heritageISMB
A personal stream of consciousness in 60 slides: from Physical to Digital and beyond, encompassing themes like culture dualisms, value chains and workflows, challenges, opportunities and other topics, to suggest a rich design space.
The Social Digitization Workshop of the Silesian Digital Library at the Siles...Śląska Biblioteka Cyfrowa
Presentation given at the third European Congress on E-Inclusion ‘Transforming Access to Digital Europe in Public Libraries’ (ECEI11), European Parliament, Brussels
Project "The Digital City Revives, A Case Study of Web Archaeology"Tjarda de Haan
Presentation at the iPRES 2016, 13th International Conference on Digital Preservation. Bern, October 3-6, 2016
By Tjarda de Haan, guest e-curator & web archaeologist at the Amsterdam Museum
Partners:
National Coalition Digital Preservation, Netherlands Institute for Sound and Vision, Old inhabitants, (ex) DDS employees and DDS affiliated web-archeologists, UvA Faculty of Science and Waag Society
Visit:
http://www.dpconline.org/newsroom/latest-news/1777-qthe-digital-city-revivesq-a-case-study-of-web-archaeology
http://hart.amsterdammuseum.nl/re-dds
http://www.bitsandbytesunited.com/?portfolio=publication-the-reconstruction-of-the-digital-city-a-case-study-of-web-archaeology
Digital Cultural Heritage and the new EU Framework Programmelocloud
2nd LoCloud CY Awareness Event at the Ministry of Education and Culture.
Presentation delivered by Marinos Ioannides, Cyprus University of Technology
Cyprus
5 March 2014
Definitions, issues and debates in the Digital Humanities.
• What are Digital Humanities centres? Are there new ones? For
example at Princeton!
• And organizations like HASTAC and http://www.artshumanities.
net.
• DIGHUMLAB draft mission and goals.
• European organizations, DARIAH, CLARIN, NeDiMAH, etc..
• Some famous and useful case studies, tools and methods
• Education opportunities.
• Getting started in DH..
Digital Humanities is a term that elicits both excitement and scorn in scholarly circles, and there is still a great deal of discussion as to whether it is a field of inquiry, a set of research methods, or simply a new perspective on arts and humanities research. This workshop will provide a brief survey of how the evolving theory and practice of using contemporary technology and technology-assisted research methods are impacting scholarship in the arts and humanities.
Similar to Visualizing the Past for the Present: A Summation of Interdisciplinary Digital Archaeological Research for the University of California, San Diego Graduate Student Association Award Ceremony
Presentation to Digital Humanities class at Pratt Institute on the history of computing in the field of archaeology and current digital humanities projects.
Enhancing Museum Narratives with the QRator ProjectSteve Gray
Museums & the Web 2012 session presented by Steven Gray UCL CASA and Claire Ross, UCLDH
Enhancing Museum Narratives with the QRator Project: a Tasmanian devil, a Platypus and a Dead Man in a Box.
A Virtual Learning Environment, Museum, and Library Exhibit - presentation of the paper of Valerie Hill & Stylianos Mystakidis at VSMM 2012 conference, Milan, Italy.
Sorin Hermon, 'Towards an integrated repository for research and management o...3D ICONS Project
Sorin Hermon, 'Towards an integrated repository for research and management of archaeological 3D assets', presentation given at the World Archaeology Congress, Jordan, January 2013.
Edited and revised: Overview of the international and interdisciplinary Gordon Research Conference on Visualization in Science and Education and info on key cognitive science and other visualization researchers. History of the conference, NSF workshop, and research on learning with visualizations.
Major points:
#1 Spatial and experiential issues of digital/virtual archives
#2 Archives of spatial objects and platial relationships
For Knowescape workshop, 3-4 September 2015, Valetta, Malta. Workshop: "Knowledge maps and access to digital archives". URL: http://knowescape.org/event/the-role-of-knowledge-maps-for-access-to-digital-archives/
Tectonic Storytelling with Open Source and Digital Object Identifiers - a cas...Peter Löwe
The communication of advances in research to the common public for both education and decision making is an important aspect of scientific work. An even more crucial task is to gain recognition within the scientific community,
which is judged by impact factor and citation counts. Recently, the latter concepts have been extended from
textual publications to include data and software publications.
This paper presents a case study for science communication and data citation. For this, tectonic models, Free and Open Source Software (FOSS), best practices for data citation and a multimedia online-portal for scientific content
are combined. This approach creates mutual benefits for the stakeholders: Target audiences receive information on
the latest research results, while the use of Digital Object Identifiers (DOI) increases the recognition and citation of
underlying scientific data. This creates favourable conditions for every researcher as DOI names ensure citeability and long term availability of scientific research.
In the developed application, the FOSS tool for tectonic modelling GPlates is used to visualise and manipulate
plate-tectonic reconstructions and associated data through geological time. These capabilities are augmented by the Science on a Halfsphere project (SoaH) with a robust and intuitive visualisation hardware environment.
The tectonic models used for science communication are provided by the AGH University of Science and Technology.
They focus on the Silurian to Early Carboniferous evolution of Central Europe (Bohemian Massif) and were
interpreted for the area of the Geopark Bergstraße Odenwald based on the GPlates/SoaH hardware- and software stack.
As scientific story-telling is volatile by nature, recordings are a natural means of preservation for further use, reference and analysis. For this, the upcoming portal for audiovisual media of the German National Library of Science and Technology TIB is expected to become a critical service infrastructure. It allows complex search queries, including metadata such as DOI and media fragment identifiers (MFI), thereby linking data citation and science
communication.
Mapping Social Sciences and Humanities - Impact, Orientation, Understanding A...Andrea Scharnhorst
This presentation gives an overview about the current use of science maps in evaluation, strategic planning, career development; and how they could be used in future.
Presentation given by Rebecca Grant of the Digital Repository of Ireland at the Digital Preservation for Arts, Social Sciences and Humanities (DPASSH) conference, Dublin, 26 June 2015. This paper investigates how guidance on research data management differs for researchers in the sciences, social sciences and humanities.
International Perspectives: Visualization in Science and EducationLiz Dorland
Overview of the international and interdisciplinary Gordon Research Conference on Visualization in Science and Education and info on key cognitive science and learning sciences researchers. History of the conference, NSF workshop, and research on learning with visualizations.
Similar to Visualizing the Past for the Present: A Summation of Interdisciplinary Digital Archaeological Research for the University of California, San Diego Graduate Student Association Award Ceremony (20)
Semiotics & Symbolic Anthropology: An Introduction and Discussion of how it r...Ashley M. Richter
How can technology guide the citizens of the world to a new level of cultural literacy?
This discussion of symbols and visual literacy is a primer to the importance of the palimpsests all around us and how the the data integration and visualization of the future need to capitalize on their ability to convey this information and make it meaningful to users.
First User Experiences in 3D Science Fiction Data Visualization SystemsAshley M. Richter
An overview and discussion of technology design as it relates to the first user experiences had with new technologies in science fiction and how that relates to software development for new forms of visualization and data integration systems.
tei
What are the data layers that need to come together to image and document and integrate our data about the world to generate an active living digital twin of time and space? A rapid discussion of the possibilities....
g
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Competitive intelligence for multimodal data integrationAshley M. Richter
What are some of the areas to watch to determine how things are going and what groups will get there first with respective to innovative multimodal data integration and visualization systems.
vsia gin s ar
An In-house Presentation for the Center of Interdisciplinary Science for Art, Architecture, and Archaeology which gives an overview of the 2012 Sediment Intervals &
Site De-Formation Processes:
Exploring Time Lapse Laser Scanning Capabilities & Methodologies for Archaeology Project, more colloquially known as 'Sandcastles for Science'.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Visualizing the Past for the Present: A Summation of Interdisciplinary Digital Archaeological Research for the University of California, San Diego Graduate Student Association Award Ceremony
1. Visualizing the Past for the Present:
Archaeology in an Interdisciplinary Age
Ashley M. Richter
Ashley M. Richter
PhD Student in
Anthropological Archaeology
National Science Foundation’s (NSF)
Integrative Graduate Education and Research Traineeship (IGERT) project for
Training, Research and Education in Engineering for Cultural Heritage Diagnostics (TEECH)
at the Center of Interdisciplinary Science for Art, Architecture, and Archaeology (CISA3)
at the California Institute of Telecommunication and Information Technology (Calit2)
at the University of California, San Diego (UCSD)
2. TABLE OF CONTENTS
•What is Archaeology?
•How does Cultural Heritage Diagnostic Visualization
fit in to Archaeology?
•UCSD & CISA3 pushing the cultural heritage
diagnostic visualization envelope
•Work on Integrated Tech for Data Capture &
Dissemination
•Establishment of the CISA3 Undergraduate Research
Internship (C.U.R.Is)
•The Future of Cultural Heritage Diagnostics…
3. What is Archaeology?
The Scientific Study of Material Remains
of Past Human Cultures
= Artifacts and Sites
4. Why?
So that we can try and interpret intersections
between Objects, Space, and Time
to make sense of our past.
Often works best to visualize for dissemination
- timelines, maps, etc…= BIG DATA issues
5. I study spatial relations within sites and
the placement of sites within the
landscape.
V.S
.
The center of campus
has moved as the
campus expanded
Roman Dining vs Contemporary Dining at the Loft
9. PHYSICAL
Evolving Data Capturing Technologies
Mean
INTANGIBLE
(Ceci n’est pas le site!)
The Site A Photograph of the Site
(2D)
Accurate 3D Point Cloud
Model of the Site
10.
11. Layered Realities!!
3D Immersive Cave Systems
Collaborative Visualization Walls
Augmented Reality: ARtifact
Capable Point Rendering Software
16. SANDCASTLES FOR SCIENCE
NSF-IGERT Mini- Grant Project: Sediment Interval & Site Deformation Processes:
Exploring Time Lapse Laser Scanning Capabilities & Methodologies for Archaeology
17. Jordan 2012:
Back at Faynan looking at integrating more
technologies into the data capture process…
18. Invited to collect data at Petra….
The Temple of the Winged Lions with the
American Center of Oriental Research’s
Conservation Project
23. The CISA3 Undergraduate Research Interns:
Past & Present
•Rebecca Asch, International Studies, Data Collection Management
•Shelby Cohantz, Cognitive Science, Neurological User Interface Design
•James M. Darling, Cognitive Science, Phenomenological User Interface Design
•Ross Davison, Archaeology, Laser Scanning Use in Field Archaeology
(now graduated, works with CyArk)
•Jonathan Eliashiv, Geophysics, Underwater Site De-Formation
•Aliya Hoff, Anthropology- Underwater Archaeology
•Kat Huggins, Anthropology, Illustration Apps, Materiality & 3D Printing
•Annie Jessup-Snyder, Visualizing Lithic Typologies
•Jessica Linback, International Studies, Data Hierarcihes for Point Clouds
•Bridget McGovern, Linguistics, Education Outreach
•Adrian Phillips, ICAM, Social Implications of Augmented Reality Systems
•Savannah Shifrin, Anthropology, Coastal Site Deformation
•Leah Trujillo, Anthropology, Education Outreach
(graduated- now works for LACHMA)
•Lillian Wakefield, Environmental Chemistry, XRF & Multispectral Imaging for Cultural
Heritage Diagnostic Visualization
24.
25.
26. Taking our terrestrial data collection and visualization
methodologies and applying them towards underwater
cultural heritage surveys
Underwater Archaeology
32. ACKNOWLEDGEMENTS
•The National Science Foundation (NSF) Education and Research Traineeship (IGERT)
project for Training, Research and Education in Engineering for Cultural Heritage
Diagnostics (TEECH)
• the Center of Interdisciplinary Science for Art, Architecture, and Archaeology (CISA3)
•
• the California Institute of Telecommunication and Information Technology (Calit2)
•
•the Anthropology Department at the University of California, San Diego (UCSD)
•My fellow CISA3 Asgardians: Vid Petrovic, Tom Wypych, David Vanoni, and Andrew
Huyhn
•My CISA3 colleagues, esp: John Mangan, Joe DeBlasio, David Srour, Jason Kimball
•My CURIs- especially James Darling and Aliya Hoff
•Professors Thomas E. Levy (Anthropology), Falko Kuester (Computer Science &
Engineering), Maurizio Seracini (EmerituS Engineering)
•The fabulous Alex Hubenko and amazing Vanessa Pool
Thank GSA and UCSD
Intro slide, mention Levy and Falko and Maurizio
Therefore Archaeology is looking at the intersection between space and time- involves a lot of visualization- timelines, maps, etc…
Roman dining room examples vs spatiality in the Loft…UCSD campus- old campus center at Old Student Center -new campus center at Price Center- can look at evolution of the school through the placement of its architecture throughout the landscape
Traditionally done by hand, or more recently point by point via GIS mapping-single points
maps-measuring tape, phenomenology, photographs
But we’d assume that in today’s modern world, we’d assume that all of that wonderful tech gets applied to archaeology and pop culture sources speak to this having happened and to science fiction potential for high speed data capture and visualization
Bones
CSI
Prometheus LiDAR balls
BUT ITS NOT YET SO- visual data manipulation limited, 3D modelling mostly- one offs- not a systems for entering, storing, and accessing information
Single point data capture has turned into being able to capture billions of points (aka point clouds) through laser scanning technology like terrestrial LiDAR (Light Detection and Ranging) and Photogrammetric techniques like structured light and structure from motion- the latter of which turns photographs into low density point clouds
Physical to Digital- New questions of materiality… Studying Spatial relations withouth being at site or looking at point clouds of objects- = non-intrusive potential for archaeology as well as a possible scaffold for all other data to live on
Do have archive systems-like CyArk- which was dev by the creator of laser scanning tech and with whom I was initially trained…
But its mostly static, and of data collected without enforced standards for quality assurance
BUT in order to get to those pop culture promises of survey visualization- need to take everything several steps further then piecemeal archives
Need standards and new vis systems which are developed for cultural heritage information
UCSD is one of the forerunners of visualization systems and here are starting to build these systems
VizWalls, CAVES, Visicore & Augmented Reality
As part of CISA3- could start pushing the archaeological visualization envelope- was already working on cultural heritage artifacts (DaVinci and Italy),
how could we apply this field archaeology…
CENTER OF INTERDISCIPLINARY SCIENCE FOR ART, ARCHITECTURE, and ARCHAEOLOGY
As an archaeologist- approached the initial data collection problems- how can we use laser scanning tech (LiDAR) for quick data collection in excavation and surveying environments
Solved certain archaeology specific field issues-
Resulted in Enhanced speed
My trial system at Khirbat Faynan in southern Jordan worked so well that we applied it to a nearby endangered site
The Birth of Rescue LiDAR: Umm al-Amad
Both look great- but we can do better with integrated tech….Sandcastles for Science photogrammetry vs. cloud- both need to be enhanced for higher resolution detail and how to handle temporal data
So this past year when we went back to Jordan- we took several other technologies with us to start building a more intense ‘data scaffold’
Structure from Motion & ARtifact--- TEMPORAL SCANNING
Ways to use multiple data capture techs simultaneously
Building new systems, methodologies, and workflows- Faynan & Petra
Adding in Structure from motion (point clouds made from photographs)- point out comparative photograph at the bottom….
INVITED to try it out at Petra
Continuing to add in other tech- looking at working in structured light, CavCams, …
Continuing to add more- looking at structured light etc
Balboa Park testing, Italy this fall
Building up a data capture system so that we have high quality, scientifically collected data to be the scaffold for additional, annotations of other types of media and textual data for dissemination in layered realities- 3D immersive and AR- can use in the field for diagnostic purposes and for general dissemination =- a new way to auto publish and continue adding to public data
= a big picture plan to try to get cultural heritage interests and tech to grow together into a purpose-driven system that enhances both the state of visualization technology and the field of archaeology/cultural heritage
Involves interdisciplinary research on the part of everyone involved- and there’s a lot of people involved because it cant be done by one person alone-collaboration is ESSENTIAL to getting big dream off the ground
Not just with wonderful professors and my amazing graduate student colleagues- essential to get the younger generations involved –they’ll be the ones who pursue this further than I can at its very start
So after collecting a few amazing undergraduate research assistants, coerced my awesome advisors into establishing a CISA3 Undergraduate Research Internship for them- a research driven class of sorts with each student working towards a research offshoot connected to the wider CISA3 goals – projects which I monitor and am actively involved in
List of CURIs
Range from the dissemination end of the big picture and Cognitive Science themed projects testing for and creating a cognitively minded user interface for accessing data in AR and 3D
Through educational outreach initiatives..
And back to the issues of data collection- how can we follow our terrestrial methodologies for underwater archaeology?
And how can we incorporate not just visual data- but compositional data as well?- material science and chemistry
Industrial radiography and xrf (x-ray flourescence)
All of my projects and my undergraduates projects add into my colleagues and professors projects to cumulatively build towards the end science fiction goal of interactive, immersive, virtual systems of data transparency and access for cultural heritage purposes- which as one of the biggest possible and time sensitive contributors of big data in need of organizing and crunching- is the perfect theme to develop these survey and storage techniques within -
Its new and its wonderful and will always stay interdisciplinary
Yay for UCSD for embracing this concept and allowing for liminal and blendy activities
Lots of names have been bandied about to title this concept- but we particularly like cultural heritage diagnostics
Hopefully liminal breadth will be recognized as program of its own…
Acknowledgements
The Essence of Cannibalism: Come visit us, we enjoy people