This document discusses the use of e-science, or collaborative science using advanced computing and networking infrastructure, in archaeology. It describes how e-science allows for global collaboration, sharing of resources securely over networks, and new forms of collaboration. Examples provided include projects linking digital archives and publications, using geospatial modeling to simulate ancient battles, and constructing geodatabases of archaeological evidence like tephra deposits. E-science provides opportunities to better analyze and understand large, heterogeneous archaeological data sources.