1. The document examines post-transcriptional regulation of VEGFA mRNA by the tumor suppressor VHL. 2. It finds that VHL promotes ubiquitylation and degradation of the RNA-binding proteins AUF1 and HuR under normoxic conditions. This allows AUF1 and HuR to stabilize and increase VEGFA mRNA. 3. Under hypoxic conditions, reduced VHL activity prevents degradation of AUF1 and HuR. This allows them to interact with and destabilize VEGFA mRNA, decreasing its levels. Therefore, VHL and oxygen tension regulate VEGFA expression through effects on AUF1 and HuR.