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Introduction
• Lower urinary tract symptoms (LUTS)
before POP surgery
• LUTS after POP surgery
 epidemiology
 evaluation
 interpretation
LUTS before POPsurgery
• Up to 63% with bulge symptoms
• Up to 73% with UI
• Up to 86% urgency or frequency
• Up to 62% voiding dysfunction
OABand QoL
Urinary Distress Inventory (UDI)
(ext. version)
Pelvic FloorDistress Inventory (PFDI)
PFDI
Incontinence Impact Questionnaire (IIQ)
(ext. Version)
Incontinence Impact Questionnaire (IIQ)
(short version)
Pelvic FloorImpact Questionnaire (PFIQ)
OABand POP
• OAB & POP are both common
conditions
• POP is not a causative factor of OAB
but is a coincidental finding…
• ...but there is a causal link
OABand POP
• Relative Risk (RR) of OAB in women with
POP is 2.1-5.8
• Conflicting data about relationship
between stage/compartment POP and OAB
symptoms
• In all studies there was an improvement in
OAB after POP surgery (up to 69%)
• Thus the strong link between POP and
OAB seems quite compelling
Effect of POPsurgery on OAB
Effect of POPsurgery on OAB
Effect of POPsurgery on OAB
OABafterPOPsurgery without SUI
surgery
Different risk patterns for different OAB
symptoms:
• Post-op frequency and urgency less common
in women with higher pre-op POP-Q stages
• Use of vaginal mesh material had a favorable
effect on urgency
• Previous hysterectomy predictor for
bothersome post-op urgency
Evidence emerging by studies without UD:
Effect of POPsurgery on OAB
OABafterPOPsurgery without SUI
surgery
OABafterPOPsurgery without SUI
surgery
“It is the chang e in opening pressure rather
than the baseline value which is of importance
in symptom resolution”
OABafterPOPsurgery without SUI
surgery
Evidence emerging by studies with UD:
• Improvement of the flow rate and fall of the
opening pressure related to improvement
• Relationship between preoperative DO(OR
0.2) and bladder trabeculation (OR 6.1) and
improvement of UUI after surgery
• Higher preoperative detrusor pressure was
associated with persistence of symptoms
Effect of POPsurgery on DO
Effect of POPsurgery on DO
• Most studies showed an improvement
after POP surgery but the effect is not of
the same magnitude as for OAB symptoms
(RR>1)
Effect of POPsurgery on OAB
OABafterPOPsurgery with SUI
surgery
Controversial findings !!
• Preoperative DO as predictor for persistence
of OAB complaints after surgery
• Preoperative DO as predictor of improvement
De novo OABafterPOPsurgery
• Prevalence: 5-22 %
• Older age, BMI and SUI surgery were risk
factors for de novo OAB and UUI
• After correction for age and BMI, only
concomitant SUI surgery was predictor for de
novo OAB and UUI
Effect of POPsurgery on voiding
• Placement of vaginal ring pessary led to a
normal free-flow rate in 94% of women with
grade 3 or 4 cystocele
• Vaginal ring pessary mimics the surgical
correction of prolapse and improve voiding
by relieving urethral kinking caused by
cystocele
Effect of POPsurgery on voiding
• It has been hypothesized that women with
significant POP, particularly of the anterior
vaginal wall, may have impaired bladder
emptying owing to a “kink” in the normal
urethral mechanism
• Because of this, these women may also
have voiding dysfunction
Effect of POPsurgery on voiding
• Distinction between detrusor underactivity
and bladder outlet obstruction in women is
very difficult:
Cystometry and pressure flow studyCystometry and pressure flow study
• not well validated methods to evaluate detrusor
contractility
• controversial urodynamic definition of obstructiion
• useful relationship pressure/flow for the diagnosis
of obstruction (high Pdet/low Qmax)
• nomograms validated only in male patients
Effect of POPsurgery on voiding
• The cause of this obstruction or outlet
resistance is not fully understood
• Mechanical urethral kinking
• Urethral and/or bladder neck compression
by the cystocele
• Alteration of urethral innervation affecting
urethral relaxation, detrusor contraction and
efficient bladder emptying
Effect of POPsurgery on voiding
• Women with proven voiding dysfunction on
free flowmetry were more likely to have a
cystocele and an intact retrovesical angle on
ultrasound
Effect of POPsurgery on voiding
• An enterocele was consistently associated
with low flow rate, indicating that repair of
posterior vaginal wall may solve voiding
dysfunction
Effect of POPsurgery on voiding
• Hence voiding dysfunction is not only related
to the anterior vaginal wall prolapse and repair
of other prolapsed compartment may also
result in resolution of voiding dysfunction and
possibly OAB
• The ultrasound appearance of the bladder
neck and retrovesical angle may be more
important in function than the stage of prolapse
seen clinically
• The use of ultrasound to assess the bladder
and voiding function is worthy of more
research
Occult stress urinary incontinence
(OSUI) and POP
• OSUI prior POP surgery: 5-30%
• Due to the lack of randomised controlled
trials there are not clearly defined treatment
strategies for POP and OSUI
• Positive association between OSUI and post
operative SUI (15% subjective SUI)
• However OSUI does not adequately identify
individual women in need of prophylactic anti-
incontinence surgery undergoing POP repair
Occult stress urinary incontinence
(OSUI) and POP
• “. . . in wo m e n with O SIand PO P, a clinician
wo uld have to inse rt 1 0 TVT to pre ve nt 1
wo m an fro m re q uiring a sling 2-4 ye ars po st-
o pe rative ly”
De novo SUI afterPOPsurgery
De novo SUI afterPOPsurgery
De novo SUI afterPOPsurgery
ICI
De novo SUI afterPOPsurgery
Valutazione e interpretaz delle alterazioni minzionali dopo chirurgia del prolasso_Curti

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Valutazione e interpretaz delle alterazioni minzionali dopo chirurgia del prolasso_Curti

  • 1.
  • 2. Introduction • Lower urinary tract symptoms (LUTS) before POP surgery • LUTS after POP surgery  epidemiology  evaluation  interpretation
  • 3. LUTS before POPsurgery • Up to 63% with bulge symptoms • Up to 73% with UI • Up to 86% urgency or frequency • Up to 62% voiding dysfunction
  • 4.
  • 5.
  • 7. Urinary Distress Inventory (UDI) (ext. version)
  • 10. Incontinence Impact Questionnaire (IIQ) (ext. Version)
  • 11. Incontinence Impact Questionnaire (IIQ) (short version)
  • 13. OABand POP • OAB & POP are both common conditions • POP is not a causative factor of OAB but is a coincidental finding… • ...but there is a causal link
  • 14. OABand POP • Relative Risk (RR) of OAB in women with POP is 2.1-5.8 • Conflicting data about relationship between stage/compartment POP and OAB symptoms • In all studies there was an improvement in OAB after POP surgery (up to 69%) • Thus the strong link between POP and OAB seems quite compelling
  • 18. OABafterPOPsurgery without SUI surgery Different risk patterns for different OAB symptoms: • Post-op frequency and urgency less common in women with higher pre-op POP-Q stages • Use of vaginal mesh material had a favorable effect on urgency • Previous hysterectomy predictor for bothersome post-op urgency Evidence emerging by studies without UD:
  • 21. OABafterPOPsurgery without SUI surgery “It is the chang e in opening pressure rather than the baseline value which is of importance in symptom resolution”
  • 22. OABafterPOPsurgery without SUI surgery Evidence emerging by studies with UD: • Improvement of the flow rate and fall of the opening pressure related to improvement • Relationship between preoperative DO(OR 0.2) and bladder trabeculation (OR 6.1) and improvement of UUI after surgery • Higher preoperative detrusor pressure was associated with persistence of symptoms
  • 24. Effect of POPsurgery on DO • Most studies showed an improvement after POP surgery but the effect is not of the same magnitude as for OAB symptoms (RR>1)
  • 26. OABafterPOPsurgery with SUI surgery Controversial findings !! • Preoperative DO as predictor for persistence of OAB complaints after surgery • Preoperative DO as predictor of improvement
  • 27. De novo OABafterPOPsurgery • Prevalence: 5-22 % • Older age, BMI and SUI surgery were risk factors for de novo OAB and UUI • After correction for age and BMI, only concomitant SUI surgery was predictor for de novo OAB and UUI
  • 28. Effect of POPsurgery on voiding • Placement of vaginal ring pessary led to a normal free-flow rate in 94% of women with grade 3 or 4 cystocele • Vaginal ring pessary mimics the surgical correction of prolapse and improve voiding by relieving urethral kinking caused by cystocele
  • 29. Effect of POPsurgery on voiding • It has been hypothesized that women with significant POP, particularly of the anterior vaginal wall, may have impaired bladder emptying owing to a “kink” in the normal urethral mechanism • Because of this, these women may also have voiding dysfunction
  • 30. Effect of POPsurgery on voiding • Distinction between detrusor underactivity and bladder outlet obstruction in women is very difficult: Cystometry and pressure flow studyCystometry and pressure flow study • not well validated methods to evaluate detrusor contractility • controversial urodynamic definition of obstructiion • useful relationship pressure/flow for the diagnosis of obstruction (high Pdet/low Qmax) • nomograms validated only in male patients
  • 31. Effect of POPsurgery on voiding • The cause of this obstruction or outlet resistance is not fully understood • Mechanical urethral kinking • Urethral and/or bladder neck compression by the cystocele • Alteration of urethral innervation affecting urethral relaxation, detrusor contraction and efficient bladder emptying
  • 32. Effect of POPsurgery on voiding • Women with proven voiding dysfunction on free flowmetry were more likely to have a cystocele and an intact retrovesical angle on ultrasound
  • 33. Effect of POPsurgery on voiding • An enterocele was consistently associated with low flow rate, indicating that repair of posterior vaginal wall may solve voiding dysfunction
  • 34. Effect of POPsurgery on voiding • Hence voiding dysfunction is not only related to the anterior vaginal wall prolapse and repair of other prolapsed compartment may also result in resolution of voiding dysfunction and possibly OAB • The ultrasound appearance of the bladder neck and retrovesical angle may be more important in function than the stage of prolapse seen clinically • The use of ultrasound to assess the bladder and voiding function is worthy of more research
  • 35. Occult stress urinary incontinence (OSUI) and POP • OSUI prior POP surgery: 5-30% • Due to the lack of randomised controlled trials there are not clearly defined treatment strategies for POP and OSUI • Positive association between OSUI and post operative SUI (15% subjective SUI) • However OSUI does not adequately identify individual women in need of prophylactic anti- incontinence surgery undergoing POP repair
  • 36. Occult stress urinary incontinence (OSUI) and POP • “. . . in wo m e n with O SIand PO P, a clinician wo uld have to inse rt 1 0 TVT to pre ve nt 1 wo m an fro m re q uiring a sling 2-4 ye ars po st- o pe rative ly”
  • 37. De novo SUI afterPOPsurgery
  • 38. De novo SUI afterPOPsurgery
  • 39. De novo SUI afterPOPsurgery ICI
  • 40. De novo SUI afterPOPsurgery