The document discusses various bacterial diseases categorized by pathogenic bacteria, symptoms caused, and mechanisms of infection. Key points include:
1) Common bacterial infections in children include those caused by Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae type b, which can cause pneumonia, meningitis, and other diseases.
2) Sexually transmitted diseases discussed are gonorrhea (caused by Neisseria gonorrhoeae), chancroid (Haemophilus ducreyi), granuloma inguinale, and syphilis (Treponema pallidum).
3) Enteropathogenic bacteria like Salmonella, Shigella,
This document discusses several bacterial diseases, focusing on Neisseria species. It provides classification, characteristics, and pathogenic details of Neisseria meningitidis and Neisseria gonorrhoeae. N. meningitidis can cause meningitis and has 13 serogroups. It is transmitted through respiratory droplets. N. gonorrhoeae causes the sexually transmitted infection gonorrhea and has developed resistance to penicillin. The document also briefly mentions Corynebacterium diphtheriae and its ability to produce a pseudomembrane in the throat through a toxin.
Lecture 3. diseases caused by bacterial infectionIffah Raniya
This document provides an overview of bacterial skin diseases and infections. It discusses several gram-positive bacteria like Staphylococcus and Streptococcus that can cause infections. It describes common skin infections from Staphylococcus like folliculitis and boils. It also covers Streptococcus and the skin infection of scarlet fever. The document further discusses gram-negative pathogens such as Pseudomonas, Vibrio, E. coli, Campylobacter, Helicobacter, and Neisseriae that can infect the skin. It provides details on diseases associated with these bacteria and their characteristics, transmission, pathogenesis and symptoms.
This case study involves a 40-year-old intravenous drug user who presented with cellulitis in the right arm along with fever and dizziness. Blood tests revealed abnormal EKG and murmur. Streptococcus pyogenes was isolated from blood cultures and identified using Gram stain and Lancefield serology. The patient was diagnosed with systemic Streptococcal infection including cellulitis, streptococcal toxic shock syndrome, and bacterial endocarditis likely resulting from repeated IV drug use. Treatment involved intravenous antibiotics and supportive care.
This document discusses Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA). It describes the identification and characteristics of S. aureus, including its ability to cause various infections like abscesses, sepsis, impetigo, and toxic shock syndrome. MRSA is defined as S. aureus resistant to beta-lactam antibiotics like methicillin due to the mecA gene. MRSA infections are difficult to treat and prevention relies on hand washing and infection control practices. Community-associated MRSA strains often contain the Panton-Valentine leukocidin toxin which increases virulence.
This document discusses the aerobic actinomycete Nocardia. It begins by classifying Nocardia taxonomically and noting it is an opportunistic pathogen found in soil. The document then covers the epidemiology, pathogenesis, clinical manifestations including pulmonary, skin and disseminated infections, diagnosis through microscopy, culture and molecular methods, and treatment with antimicrobials. In summary, Nocardia is an environmental actinomycete that can cause infection in immunocompromised individuals, with pulmonary disease being most common and diagnosis relying on microscopy, culture and molecular identification methods.
This document provides an overview of Rickettsiae, including their classification, characteristics, life cycle, transmission, and pathogenic species. Rickettsiae are obligate intracellular bacteria that parasitize arthropod and vertebrate cells. They are transmitted between hosts by arthropod vectors like ticks and mites. Major diseases discussed include Rocky Mountain spotted fever caused by Rickettsia rickettsii transmitted by ticks, and typhus caused by R. prowazekii transmitted between humans by body lice. The document outlines the classification, characteristics, life cycles and transmission mechanisms of the main Rickettsiae genera.
The document discusses various bacterial diseases categorized by pathogenic bacteria, symptoms caused, and mechanisms of infection. Key points include:
1) Common bacterial infections in children include those caused by Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae type b, which can cause pneumonia, meningitis, and other diseases.
2) Sexually transmitted diseases discussed are gonorrhea (caused by Neisseria gonorrhoeae), chancroid (Haemophilus ducreyi), granuloma inguinale, and syphilis (Treponema pallidum).
3) Enteropathogenic bacteria like Salmonella, Shigella,
This document discusses several bacterial diseases, focusing on Neisseria species. It provides classification, characteristics, and pathogenic details of Neisseria meningitidis and Neisseria gonorrhoeae. N. meningitidis can cause meningitis and has 13 serogroups. It is transmitted through respiratory droplets. N. gonorrhoeae causes the sexually transmitted infection gonorrhea and has developed resistance to penicillin. The document also briefly mentions Corynebacterium diphtheriae and its ability to produce a pseudomembrane in the throat through a toxin.
Lecture 3. diseases caused by bacterial infectionIffah Raniya
This document provides an overview of bacterial skin diseases and infections. It discusses several gram-positive bacteria like Staphylococcus and Streptococcus that can cause infections. It describes common skin infections from Staphylococcus like folliculitis and boils. It also covers Streptococcus and the skin infection of scarlet fever. The document further discusses gram-negative pathogens such as Pseudomonas, Vibrio, E. coli, Campylobacter, Helicobacter, and Neisseriae that can infect the skin. It provides details on diseases associated with these bacteria and their characteristics, transmission, pathogenesis and symptoms.
This case study involves a 40-year-old intravenous drug user who presented with cellulitis in the right arm along with fever and dizziness. Blood tests revealed abnormal EKG and murmur. Streptococcus pyogenes was isolated from blood cultures and identified using Gram stain and Lancefield serology. The patient was diagnosed with systemic Streptococcal infection including cellulitis, streptococcal toxic shock syndrome, and bacterial endocarditis likely resulting from repeated IV drug use. Treatment involved intravenous antibiotics and supportive care.
This document discusses Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA). It describes the identification and characteristics of S. aureus, including its ability to cause various infections like abscesses, sepsis, impetigo, and toxic shock syndrome. MRSA is defined as S. aureus resistant to beta-lactam antibiotics like methicillin due to the mecA gene. MRSA infections are difficult to treat and prevention relies on hand washing and infection control practices. Community-associated MRSA strains often contain the Panton-Valentine leukocidin toxin which increases virulence.
This document discusses the aerobic actinomycete Nocardia. It begins by classifying Nocardia taxonomically and noting it is an opportunistic pathogen found in soil. The document then covers the epidemiology, pathogenesis, clinical manifestations including pulmonary, skin and disseminated infections, diagnosis through microscopy, culture and molecular methods, and treatment with antimicrobials. In summary, Nocardia is an environmental actinomycete that can cause infection in immunocompromised individuals, with pulmonary disease being most common and diagnosis relying on microscopy, culture and molecular identification methods.
This document provides an overview of Rickettsiae, including their classification, characteristics, life cycle, transmission, and pathogenic species. Rickettsiae are obligate intracellular bacteria that parasitize arthropod and vertebrate cells. They are transmitted between hosts by arthropod vectors like ticks and mites. Major diseases discussed include Rocky Mountain spotted fever caused by Rickettsia rickettsii transmitted by ticks, and typhus caused by R. prowazekii transmitted between humans by body lice. The document outlines the classification, characteristics, life cycles and transmission mechanisms of the main Rickettsiae genera.
This document discusses various infectious diseases caused by viruses, bacteria, and parasites. It provides details on pathogens such as influenza virus, herpes virus, tuberculosis (M. tuberculosis), leprosy (M. leprae), streptococcal infections, and parasitic infections including schistosomiasis and hydatid cyst. For each disease, it describes the causative agent, pathogenesis, clinical manifestations, pathological features, and complications.
This document discusses various body fluids and their microbiological analysis. It describes serous fluids as either transudates which are non-infected or exudates which contain inflammatory cells and pathogens. Examples of serous fluids covered include pleural, peritoneal, pericardial, synovial, hydrocele fluids. For each fluid, the document discusses locations in the body, potential causes of infection, and laboratory methods for diagnosis including collection, staining, culturing and examining samples.
Selected human infectious diseases part 2Jason Sulit
This document describes staphylococcal scalded skin syndrome (SSSS) and toxic epidermal necrolysis (TEN) in neonates and children. It includes photos showing large areas of skin denudation and blistering. SSSS is caused by a toxin that separates the epidermis from the dermis. The affected areas dry out and flake off over 2 weeks. It is treated with intravenous penicillin and fluid replacement. TEN has a similar appearance but is usually drug-induced or due to infection. High-dose steroids may be used to treat TEN. Biopsy is important to differentiate the two conditions.
This document summarizes bacterial infections caused by Streptococcus and Staphylococcus bacteria. It discusses the classification of infections and virulence factors of pathogens. It describes Streptococcal infections including alpha-hemolytic and beta-hemolytic Streptococci. Specific Streptococcal diseases like scarlet fever and bacterial meningitis are mentioned. Staphylococcal infections involving the skin/soft tissues or being invasive are outlined, including boils, impetigo, cellulitis, and sepsis. The document provides an overview of key bacterial infections and the microbes that cause them.
Actinomycetes and Nocardia, Bacteria but similar to fungi usually because of its morphological feature of forming a branching filament network, causing Actinomycosis, Actinomycetoma, Farmer's Lung, etc. Demonstrated under microscope by Gram's stain and ZN staining. Cultured on BHI and Thioglycolate broth. Characteristically produce Supher granules. Penicillin is the drug of choice in allergic to penicillin can be replaced by Erythromycin or Tetracycline. In worst cases surgical removal of affected tissue required.
This document provides information about Klebsiella, including its classification, description, antigenic structure, virulence factors, pathogenesis, laboratory diagnosis, and treatment. It discusses that Klebsiella are Gram-negative rods that are non-motile and produce a pronounced capsule. They can cause both community and hospital-acquired infections like pneumonia, UTIs, and bacteremia. Laboratory identification involves culture, Gram stain, and biochemical testing. Treatment involves antibiotics that can overcome Klebsiella's beta-lactamase production, such as certain cephalosporins, fluoroquinolones, and carbapenems.
This document provides information on Entamoeba histolytica, a pathogenic protozoan parasite. It outlines the etiology, epidemiology, pathogenesis, clinical manifestations, diagnosis, treatment, and complications of E. histolytica infection. Key points include:
- E. histolytica infects up to 10% of the world's population and is a major cause of parasitic death. It typically causes asymptomatic colonization but can lead to amebic colitis or liver abscess.
- Infection occurs through ingestion of cysts in contaminated food/water. Cysts excyst in the intestine and trophozoites may invade the colonic mucosa.
- Diagnosis involves antigen detection in stool
S. pyogenes is a Gram-positive bacterium that commonly causes infections of the skin and throat. It is transmitted through direct contact with infected individuals. The bacterium produces several virulence factors like M protein, capsule, and streptokinase that help it evade the immune system and spread infection. Common diseases caused include pharyngitis, impetigo, and necrotizing fasciitis. Treatment involves antibiotics like penicillin.
Actinomycetes are a group of gram-positive bacteria that form branching filaments and resemble fungi. They include the genera Actinomyces, Norcardia, and Streptomyces. Actinomyces are anaerobic bacteria that are part of normal oral and gut flora and can cause actinomycosis, a chronic suppurative infection. Nocardia are partially acid-fast aerobic bacteria that are opportunistic pathogens commonly causing nocardiosis, a lung infection or disseminated disease in immunocompromised individuals. Actinomycetes play an important environmental role in soil decomposition and are a major source of antibiotics produced industrially.
Chlamydia is an obligate intracellular bacterium that can cause several diseases in humans. It has a unique life cycle alternating between two forms - the infectious elementary body and the dividing reticulate body. C. trachomatis is the most common species and can cause trachoma, sexually transmitted diseases like urethritis and cervicitis. C. psittaci causes psittacosis transmitted from birds while C. pneumoniae causes atypical pneumonia. Diagnosis involves culture or serology while treatment uses tetracycylines or macrolides. Prevention focuses on abstinence, barrier methods and controlling infection in birds.
Bacterial infections of the oral cavity can take many forms. Scarlet fever is caused by Streptococcus bacteria and presents with a red rash and strawberry tongue. Tuberculosis is caused by Mycobacterium tuberculosis and typically causes lesions in the lungs but can also cause oral ulcers, gingivitis, and osteomyelitis of the jaw. Diphtheria is caused by Corynebacterium diphtheriae and presents with a diphtheritic membrane that can cover the tonsils, soft palate, and throat.
Leptospirosis is a bacterial disease caused by Leptospira interrogans that is distributed worldwide but mostly affects populations in rural and semi-urban areas. It is transmitted through contact with water or soil contaminated by infected animal urine. Clinical presentation varies from mild flu-like symptoms to severe disease affecting multiple organs. Diagnosis involves serological tests, culture or PCR. Treatment is with doxycycline or penicillin with supportive care for organ complications. Prevention focuses on rodent control, vaccination of animals, and avoiding contact with contaminated water sources.
Klebsiella is a genus of Gram-negative, facultatively anaerobic, rod-shaped bacteria that is commonly found in soil and water. The most important species in medicine are K. pneumoniae, K. aerogenes, K. oxytoca, and K. rhinoscleromatis. K. pneumoniae is an opportunistic pathogen that can cause infections of the urinary tract, wounds, pneumonia, and sepsis. It is identified through Gram staining, growth on selective media, and biochemical testing. Treatment involves cephalosporins and aminoglycosides as Klebsiella often produces beta-lactamases making it resistant to ampicillin.
This document summarizes information about the bacteria Klebsiella. It belongs to the genus Klebsiella within the family Enterobacteriaceae. Klebsiella is a facultative anaerobe found in the normal flora of humans. It can cause various opportunistic infections especially in immunocompromised individuals. While some Klebsiella infections respond to antibiotics, some strains have developed resistance. Carbapenem-resistant Klebsiella pneumoniae can be difficult to treat.
BACTERIAL DISEASES OF FOXES.
All of the information are collected , it's not a research work but I think it will help the students to know about the basic information.
This document provides an overview of histoplasmosis, including its epidemiology, pathophysiology, clinical manifestations, diagnosis, and treatment. It describes how histoplasmosis is caused by the dimorphic fungus Histoplasma capsulatum, which exists as a mold in the environment and a yeast in tissues. Most infections are asymptomatic, but symptomatic cases can range from mild acute pulmonary infection to potentially fatal disseminated infection. Diagnosis involves antigen detection, culture, histopathology, or serologic testing. Treatment with antifungals is recommended for severe or disseminated cases.
Actinomycetes are filamentous, gram-positive bacteria that can cause infections in humans. Important genera include Actinomyces, Nocardia, and Actinomadura. Actinomyces causes actinomycosis, presenting as cervicofacial abscesses with draining sinuses. Diagnosis involves microscopy of pus showing club-shaped granules and filaments. Nocardia are environmental bacteria that can cause pulmonary or disseminated nocardiosis in immunocompromised individuals. They are acid-fast and form colonies on culture. Actinomadura is a common cause of actinomycetoma, presenting as subcutaneous nodules and sinuses in the
Actinomycosis is a rare bacterial infection caused by Actinomycetaceae bacteria. It is unusual in that it can spread slowly through body tissue. It is diagnosed through biopsy and treated with long-term antibiotics and sometimes minor surgery. The infection most commonly affects the oral cavity, lungs, abdomen, or pelvis. Risk factors include poor dental hygiene, inhaling contaminated material, injuries that breach protective barriers, and long-term intrauterine device use. Symptoms vary depending on the infected area but may include lumps, sinus tracts, fever, and pain. With full treatment, actinomycosis usually responds well.
This document discusses various genital tract infections, their causes, symptoms, and laboratory diagnosis. It covers infections like urethritis, syphilis, cancroids, lymphogranuloma venereum, granuloma inguinale, herpes genitals, vaginitis, puerperal sepsis, toxic shock syndrome, and prostatitis. For laboratory diagnosis, it recommends collecting samples like urethral discharge, cervical discharge, vaginal discharge, fluids, scrapings, urine, and blood. Direct exams, cultures, and serology can be used to detect organisms causing each infection.
This document provides an overview of pathogenic cocci bacteria, focusing on Staphylococcus aureus, Neisseria gonorrhoeae, and Neisseria meningitidis. It describes the characteristics, epidemiology, pathogenesis, clinical manifestations, diagnosis, and treatment of infections caused by these bacteria. Key points include that S. aureus is a common cause of skin and soft tissue infections, N. gonorrhoeae causes the sexually transmitted infection gonorrhea, and N. meningitidis can cause meningitis and sepsis.
This document discusses several non-specific surgical infections including syphilis, gonorrhea, cancrum oris, anthrax, and actinomycosis. It provides details on the causative agents, transmission, clinical presentation, diagnosis, and treatment of each infection. Key points covered include that syphilis and gonorrhea are sexually transmitted bacterial infections, cancrum oris is a rapidly progressive infection more common in immunocompromised individuals, while anthrax causes skin, respiratory, or intestinal illness depending on transmission route.
The document summarizes diseases of the urinary and reproductive systems. It describes the structure and functions of the urinary tract and normal microbiota. It then discusses various urinary tract infections (UTIs) like cystitis and pyelonephritis caused by E. coli. It also covers sexually transmitted diseases (STDs) like gonorrhea caused by N. gonorrhoeae, syphilis caused by T. pallidum, and nongonococcal urethritis. It briefly discusses viral diseases like genital herpes and genital warts, as well as fungal infection candidiasis and the protozoan STD trichomoniasis.
This document discusses various infectious diseases caused by viruses, bacteria, and parasites. It provides details on pathogens such as influenza virus, herpes virus, tuberculosis (M. tuberculosis), leprosy (M. leprae), streptococcal infections, and parasitic infections including schistosomiasis and hydatid cyst. For each disease, it describes the causative agent, pathogenesis, clinical manifestations, pathological features, and complications.
This document discusses various body fluids and their microbiological analysis. It describes serous fluids as either transudates which are non-infected or exudates which contain inflammatory cells and pathogens. Examples of serous fluids covered include pleural, peritoneal, pericardial, synovial, hydrocele fluids. For each fluid, the document discusses locations in the body, potential causes of infection, and laboratory methods for diagnosis including collection, staining, culturing and examining samples.
Selected human infectious diseases part 2Jason Sulit
This document describes staphylococcal scalded skin syndrome (SSSS) and toxic epidermal necrolysis (TEN) in neonates and children. It includes photos showing large areas of skin denudation and blistering. SSSS is caused by a toxin that separates the epidermis from the dermis. The affected areas dry out and flake off over 2 weeks. It is treated with intravenous penicillin and fluid replacement. TEN has a similar appearance but is usually drug-induced or due to infection. High-dose steroids may be used to treat TEN. Biopsy is important to differentiate the two conditions.
This document summarizes bacterial infections caused by Streptococcus and Staphylococcus bacteria. It discusses the classification of infections and virulence factors of pathogens. It describes Streptococcal infections including alpha-hemolytic and beta-hemolytic Streptococci. Specific Streptococcal diseases like scarlet fever and bacterial meningitis are mentioned. Staphylococcal infections involving the skin/soft tissues or being invasive are outlined, including boils, impetigo, cellulitis, and sepsis. The document provides an overview of key bacterial infections and the microbes that cause them.
Actinomycetes and Nocardia, Bacteria but similar to fungi usually because of its morphological feature of forming a branching filament network, causing Actinomycosis, Actinomycetoma, Farmer's Lung, etc. Demonstrated under microscope by Gram's stain and ZN staining. Cultured on BHI and Thioglycolate broth. Characteristically produce Supher granules. Penicillin is the drug of choice in allergic to penicillin can be replaced by Erythromycin or Tetracycline. In worst cases surgical removal of affected tissue required.
This document provides information about Klebsiella, including its classification, description, antigenic structure, virulence factors, pathogenesis, laboratory diagnosis, and treatment. It discusses that Klebsiella are Gram-negative rods that are non-motile and produce a pronounced capsule. They can cause both community and hospital-acquired infections like pneumonia, UTIs, and bacteremia. Laboratory identification involves culture, Gram stain, and biochemical testing. Treatment involves antibiotics that can overcome Klebsiella's beta-lactamase production, such as certain cephalosporins, fluoroquinolones, and carbapenems.
This document provides information on Entamoeba histolytica, a pathogenic protozoan parasite. It outlines the etiology, epidemiology, pathogenesis, clinical manifestations, diagnosis, treatment, and complications of E. histolytica infection. Key points include:
- E. histolytica infects up to 10% of the world's population and is a major cause of parasitic death. It typically causes asymptomatic colonization but can lead to amebic colitis or liver abscess.
- Infection occurs through ingestion of cysts in contaminated food/water. Cysts excyst in the intestine and trophozoites may invade the colonic mucosa.
- Diagnosis involves antigen detection in stool
S. pyogenes is a Gram-positive bacterium that commonly causes infections of the skin and throat. It is transmitted through direct contact with infected individuals. The bacterium produces several virulence factors like M protein, capsule, and streptokinase that help it evade the immune system and spread infection. Common diseases caused include pharyngitis, impetigo, and necrotizing fasciitis. Treatment involves antibiotics like penicillin.
Actinomycetes are a group of gram-positive bacteria that form branching filaments and resemble fungi. They include the genera Actinomyces, Norcardia, and Streptomyces. Actinomyces are anaerobic bacteria that are part of normal oral and gut flora and can cause actinomycosis, a chronic suppurative infection. Nocardia are partially acid-fast aerobic bacteria that are opportunistic pathogens commonly causing nocardiosis, a lung infection or disseminated disease in immunocompromised individuals. Actinomycetes play an important environmental role in soil decomposition and are a major source of antibiotics produced industrially.
Chlamydia is an obligate intracellular bacterium that can cause several diseases in humans. It has a unique life cycle alternating between two forms - the infectious elementary body and the dividing reticulate body. C. trachomatis is the most common species and can cause trachoma, sexually transmitted diseases like urethritis and cervicitis. C. psittaci causes psittacosis transmitted from birds while C. pneumoniae causes atypical pneumonia. Diagnosis involves culture or serology while treatment uses tetracycylines or macrolides. Prevention focuses on abstinence, barrier methods and controlling infection in birds.
Bacterial infections of the oral cavity can take many forms. Scarlet fever is caused by Streptococcus bacteria and presents with a red rash and strawberry tongue. Tuberculosis is caused by Mycobacterium tuberculosis and typically causes lesions in the lungs but can also cause oral ulcers, gingivitis, and osteomyelitis of the jaw. Diphtheria is caused by Corynebacterium diphtheriae and presents with a diphtheritic membrane that can cover the tonsils, soft palate, and throat.
Leptospirosis is a bacterial disease caused by Leptospira interrogans that is distributed worldwide but mostly affects populations in rural and semi-urban areas. It is transmitted through contact with water or soil contaminated by infected animal urine. Clinical presentation varies from mild flu-like symptoms to severe disease affecting multiple organs. Diagnosis involves serological tests, culture or PCR. Treatment is with doxycycline or penicillin with supportive care for organ complications. Prevention focuses on rodent control, vaccination of animals, and avoiding contact with contaminated water sources.
Klebsiella is a genus of Gram-negative, facultatively anaerobic, rod-shaped bacteria that is commonly found in soil and water. The most important species in medicine are K. pneumoniae, K. aerogenes, K. oxytoca, and K. rhinoscleromatis. K. pneumoniae is an opportunistic pathogen that can cause infections of the urinary tract, wounds, pneumonia, and sepsis. It is identified through Gram staining, growth on selective media, and biochemical testing. Treatment involves cephalosporins and aminoglycosides as Klebsiella often produces beta-lactamases making it resistant to ampicillin.
This document summarizes information about the bacteria Klebsiella. It belongs to the genus Klebsiella within the family Enterobacteriaceae. Klebsiella is a facultative anaerobe found in the normal flora of humans. It can cause various opportunistic infections especially in immunocompromised individuals. While some Klebsiella infections respond to antibiotics, some strains have developed resistance. Carbapenem-resistant Klebsiella pneumoniae can be difficult to treat.
BACTERIAL DISEASES OF FOXES.
All of the information are collected , it's not a research work but I think it will help the students to know about the basic information.
This document provides an overview of histoplasmosis, including its epidemiology, pathophysiology, clinical manifestations, diagnosis, and treatment. It describes how histoplasmosis is caused by the dimorphic fungus Histoplasma capsulatum, which exists as a mold in the environment and a yeast in tissues. Most infections are asymptomatic, but symptomatic cases can range from mild acute pulmonary infection to potentially fatal disseminated infection. Diagnosis involves antigen detection, culture, histopathology, or serologic testing. Treatment with antifungals is recommended for severe or disseminated cases.
Actinomycetes are filamentous, gram-positive bacteria that can cause infections in humans. Important genera include Actinomyces, Nocardia, and Actinomadura. Actinomyces causes actinomycosis, presenting as cervicofacial abscesses with draining sinuses. Diagnosis involves microscopy of pus showing club-shaped granules and filaments. Nocardia are environmental bacteria that can cause pulmonary or disseminated nocardiosis in immunocompromised individuals. They are acid-fast and form colonies on culture. Actinomadura is a common cause of actinomycetoma, presenting as subcutaneous nodules and sinuses in the
Actinomycosis is a rare bacterial infection caused by Actinomycetaceae bacteria. It is unusual in that it can spread slowly through body tissue. It is diagnosed through biopsy and treated with long-term antibiotics and sometimes minor surgery. The infection most commonly affects the oral cavity, lungs, abdomen, or pelvis. Risk factors include poor dental hygiene, inhaling contaminated material, injuries that breach protective barriers, and long-term intrauterine device use. Symptoms vary depending on the infected area but may include lumps, sinus tracts, fever, and pain. With full treatment, actinomycosis usually responds well.
This document discusses various genital tract infections, their causes, symptoms, and laboratory diagnosis. It covers infections like urethritis, syphilis, cancroids, lymphogranuloma venereum, granuloma inguinale, herpes genitals, vaginitis, puerperal sepsis, toxic shock syndrome, and prostatitis. For laboratory diagnosis, it recommends collecting samples like urethral discharge, cervical discharge, vaginal discharge, fluids, scrapings, urine, and blood. Direct exams, cultures, and serology can be used to detect organisms causing each infection.
This document provides an overview of pathogenic cocci bacteria, focusing on Staphylococcus aureus, Neisseria gonorrhoeae, and Neisseria meningitidis. It describes the characteristics, epidemiology, pathogenesis, clinical manifestations, diagnosis, and treatment of infections caused by these bacteria. Key points include that S. aureus is a common cause of skin and soft tissue infections, N. gonorrhoeae causes the sexually transmitted infection gonorrhea, and N. meningitidis can cause meningitis and sepsis.
This document discusses several non-specific surgical infections including syphilis, gonorrhea, cancrum oris, anthrax, and actinomycosis. It provides details on the causative agents, transmission, clinical presentation, diagnosis, and treatment of each infection. Key points covered include that syphilis and gonorrhea are sexually transmitted bacterial infections, cancrum oris is a rapidly progressive infection more common in immunocompromised individuals, while anthrax causes skin, respiratory, or intestinal illness depending on transmission route.
The document summarizes diseases of the urinary and reproductive systems. It describes the structure and functions of the urinary tract and normal microbiota. It then discusses various urinary tract infections (UTIs) like cystitis and pyelonephritis caused by E. coli. It also covers sexually transmitted diseases (STDs) like gonorrhea caused by N. gonorrhoeae, syphilis caused by T. pallidum, and nongonococcal urethritis. It briefly discusses viral diseases like genital herpes and genital warts, as well as fungal infection candidiasis and the protozoan STD trichomoniasis.
Urinary tract infections (UTIs) are among the most common infections encountered by doctors. They can affect people of all ages and have a wide range of clinical manifestations, from asymptomatic to severe systemic symptoms. The urinary tract is normally sterile, and any bacterial growth in the urine constitutes a UTI regardless of bacterial count. UTIs are commonly caused by bacteria like E. coli entering the urinary tract and multiplying. Treatment depends on whether the infection is uncomplicated or complicated by anatomical or functional factors. Empiric broad-spectrum therapy is started and later adjusted based on culture and sensitivity results.
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1. The document discusses the anatomy and physiology of the digestive tract, focusing on the pathogens Salmonella, Shigella, and Yersinia.
2. It describes the characteristics and pathogenesis of Salmonella and Shigella, including their ability to invade the intestinal epithelium and cause diseases like gastroenteritis and dysentery.
3. The treatment and prevention of infections from these pathogens involves controlling contamination, identifying carriers, and using antibiotics in some cases. Proper food preparation helps control the spread of Salmonella.
Leptospirosis is a zoonotic bacterial disease caused by Leptospira interrogans bacteria transmitted through contact with infected animal urine. It is common in tropical areas with high rainfall. Symptoms range from mild flu-like illness to severe Weil's disease affecting multiple organs. Diagnosis involves exposure history plus lab tests like MAT, PCR, or culture. Treatment consists of antibiotics like doxycycline or IV penicillin for severe cases. Without treatment, causes of death include renal failure, cardiopulmonary failure, and hemorrhage.
Malaria is a disease caused by Plasmodium parasites and transmitted via the bites of infected Anopheles mosquitoes. There are four human-infecting Plasmodium species, with P. falciparum being the most deadly. Malaria transmission is influenced by factors like mosquito distribution, temperature, and patient immunity. In Tanzania, over 93% of the population lives in malaria-risk areas, making children and pregnant women most vulnerable.
Schistosomiasis is a parasitic disease caused by several species of flatworm. It affects over 200 million people in developing countries. People can become infected by wading or swimming in freshwater bodies inhabited by snails that carry the parasite larvae. The parasite has a complex lifecycle involving snail and human hosts. In humans, the larvae mature into adult worms that reside in blood vessels and release eggs, which can cause immune reactions and organ damage. Symptoms range from rash and fever during initial infection to long-term issues like bladder polyps, kidney failure, and cancer. Diagnosis involves detecting parasite eggs in stool or urine samples, and treatment is usually with the drug praziquantel.
The document discusses various types of skin and soft tissue infections including impetigo, abscesses, cellulitis, and erysipelas. It describes the typical causative bacteria, clinical presentation, risk factors, diagnosis, and treatment for each type of infection. Key points covered include how Staphylococcus aureus and Streptococcus pyogenes are the most common causes. Proper diagnosis involves considering patient history and symptoms, and treatment often involves antibiotics as well as surgical drainage or debridement for more severe cases such as necrotizing fasciitis.
This document discusses Leptospira, a pathogenic spirochete bacteria that causes leptospirosis. It is a zoonotic disease transmitted through contact with infected animal urine. Leptospira has a thin, coiled morphology and grows slowly in culture. It can penetrate skin or mucous membranes, causing a mild flu-like illness or the potentially fatal Weil's disease characterized by jaundice and kidney damage. Diagnosis involves culture, serology, or ELISA testing of blood, urine or CSF. Treatment is with penicillin or doxycycline. Prevention involves controlling rodent populations, vaccinating livestock, and taking protective measures during high risk activities like farming.
The normal human skin is colonized by many bacteria that live harmlessly in communities known as the skin microbiome. The resident bacteria include propionibacterium species in hair follicles, and aerobic cocci and coryneforms on the surface. Staphylococcus aureus and propionibacteria can produce free fatty acids from skin lipids. Impetigo is a common skin infection caused by S. aureus or streptococci, occurring as non-bullous or bullous types. Bullous impetigo is caused by exfoliative toxins that disrupt skin adhesion molecules.
This document provides an overview and schedule for the PLE Board Exam Review in 2023. The review will take place on March 12, 2023 and cover topics including IDS/communicable diseases, pulmonology, gastroenterology, and rheumatology. Each topic is allotted a specific time block and there are breaks scheduled between sections. The review also includes sample questions related to various diseases like leptospirosis, typhoid, tetanus, and others.
Urinary tract infection (UTI) is a bacterial infection that affects the urinary system, including the bladder, urethra, ureters, and kidneys. Common symptoms include frequent urination, burning sensation during urination, and lower abdominal pain. UTIs are usually treated with antibiotics, and preventive measures such as good urinary hygiene and staying hydrated can help reduce the risk. UTIs are more common in women, but can affect men, children, and the elderly as well. Prompt diagnosis and appropriate treatment are important to prevent complications and promote recovery.
Enteroviral_infection Department of Children Infection Diseases.pdfvaxbane
Enteroviral infection is caused by various enteroviruses and can manifest as mild febrile illness to more severe diseases like meningitis, myocarditis, or hepatitis. It is transmitted through direct contact or contaminated surfaces. Clinical manifestations vary and include aseptic meningitis, herpangina, hand-foot-and-mouth disease, acute hemorrhagic conjunctivitis, minor summer flu-like illness, and rashes. Diagnosis involves virus isolation from specimens, serology to detect antibody response, or PCR. Treatment is supportive and prevention relies on isolation, disinfection, and possibly immunoglobulin after exposure.
Neonatal sepsis is a clinical syndrome of systemic illness accompanied by bacteria in the blood occurring in the first month of life. It can be early-onset within the first week of life, usually acquired during birth from the mother, or late-onset between 1 week to 1 month of life, often from the hospital environment. Symptoms are non-specific but can include temperature irregularities, poor feeding, or respiratory distress. Treatment involves blood cultures, antibiotics like ampicillin and gentamicin, and supportive care for complications involving various organ systems. Future treatments may involve immunotherapies and blocking inflammatory responses.
Neonatal sepsis is a clinical syndrome of systemic illness accompanied by bacteria in the blood occurring in the first month of life. It can be early-onset within the first week of life, usually acquired during birth from the mother, or late-onset between 1 week to 1 month of life, often from hospital-acquired infections. Symptoms are non-specific but can include temperature irregularities, poor feeding, or respiratory distress. Treatment involves blood cultures, antibiotics like ampicillin and gentamicin, and supportive care for complications involving various organ systems. Ongoing research focuses on immunotherapies and blocking inflammatory responses.
The document discusses the importance of nursing informatics. It notes that informatics can help nursing practice become more visible through healthcare data, empowering nurses to influence policy. It also emphasizes that information is critical for effective decision-making and high-quality nursing care. The document recommends that nurses strive for an "innovator" level of technical competency in nursing informatics.
This document provides an overview of the gastrointestinal system, including:
- A review of gastrointestinal anatomy and physiology with emphasis on the sympathetic and parasympathetic nervous systems.
- A discussion of common gastrointestinal disorders like GERD, hiatal hernia, and esophageal cancer.
- Details on laboratory procedures used to evaluate gastrointestinal issues such as occult blood, C/S stool, and stool exams.
- Information on gastrointestinal surgical procedures including Nissen fundoplication.
The document is authored by Colleen C. Flores, RN and focuses on providing nurses with knowledge to care for patients with gastrointestinal conditions.
The document discusses various types of acute inflammatory disorders including hepatitis, appendicitis, pancreatitis, and cholecystitis. It provides details on:
1) The causes, symptoms, transmission, and prognosis of different types of hepatitis (A, B, C, D, E).
2) The pathophysiology of appendicitis as obstruction in the appendix lumen leads to inflammation, restricted blood flow, and potential perforation.
3) The pathophysiology of acute pancreatitis as spasm, edema or blockage in the ampulla of Vater causes reflux of enzymes and autodigestion of the pancreas.
4) Nursing management focuses on isolation, nutrition,
This document provides a summary of disturbances in oxygenation carrying mechanisms and transportation facilities. Specifically, it discusses issues related to disruptions in blood circulation and oxygen delivery. Key points include that disturbances can occur in the blood itself as well as the vessels and mechanisms that transport blood and oxygen throughout the body. Maintaining proper functioning of these critical systems is essential for health.
This document discusses several cardiovascular disorders related to disturbances in oxygen transport, including structural heart valve disorders like mitral valve prolapse, mitral regurgitation, and mitral stenosis. It also covers infective endocarditis, rheumatic heart disease, myocarditis, pericarditis, aortic aneurysm, and vascular disorders like Buerger's disease, Raynaud's disease, and venous thrombosis. For each condition, it provides information on clinical manifestations, diagnosis, and treatment approaches.
The document discusses proper patient positioning and equipment used for various surgical procedures, including safety belts, armboards, wrist straps, and other attachments that help expose the operative site and support the body. It also covers preoperative skin preparation and draping techniques to prevent infection and maintain a sterile field during surgery. Specific positioning and draping methods are recommended for different types of operations involving the abdomen, pelvis, spine, and other body areas.
The document defines pain and its terminology, describes the pathophysiology and perception of pain, different types of pain syndromes and management approaches, including pharmacological treatments like analgesics and non-pharmacological options like cognitive behavioral therapy and various physical therapies. Pain is a complex, subjective experience influenced by physiological, psychological, social, and cultural factors.
1. The document outlines a post-anesthesia care unit (PACU) scoring system to assess patient recovery and determine readiness for discharge. It assesses 5 areas: activity, respiration, circulation, consciousness, and color.
2. A sample patient in the document scores a 2 for each category, indicating full recovery in each area assessed.
3. A discharge score of 7-8 points is required. The scoring system provides a standardized way to evaluate patient recovery and determine appropriate timing of discharge from the PACU.
This document discusses patient safety considerations for surgery. It emphasizes providing safe patient care by ensuring the correct patient, site, and procedure. It also stresses providing a safe environment by adhering to asepsis and promoting effective communication. The document outlines steps to take in the preoperative phase like addressing nutritional deficiencies, conducting exams, and administering pre-op medications to reduce anxiety and nausea. Informed consent and surgical checklists are also addressed.
Introduction to surgery with his 1st sem 2011Bea Galang
This document discusses the history and evolution of surgery from ancient times to modern times. It covers important developments like the first surgeries performed in ancient Egypt and India, advances during the Middle Ages by surgeons like Guy de Chauliac, and seminal discoveries and techniques from the 16th century onward by figures like Ambroise Pare, William Harvey, Joseph Lister, and later pioneers of techniques like anesthesia, antisepsis, and organ transplantation. It outlines milestones from trepanation to the first heart transplant that have helped establish surgery as a major field of medicine.
This document discusses surgical instrumentation including sutures, needles, and hemostasis. It provides definitions and classifications for cutting instruments, grasping instruments, retractor instruments, and sutures/needles. Specific types of instruments are listed such as scalpels, scissors, forceps, and needle holders. Characteristics and proper use of different suture needles are also outlined.
1. Surgical drains are used to collapse surgical dead space, drain abscesses, provide early warning of leaks, and control established fistula leaks.
2. Post-operative care objectives include re-establishing physiological equilibrium, preventing pain and complications, and promoting functions like respiration, circulation, nutrition, and wound healing.
3. Common post-operative complications involve respiratory, cardiovascular, gastrointestinal, urinary, wound, and integumentary systems. Close monitoring is needed to detect and manage complications early.
This document discusses proper surgical scrub techniques and protocols. It covers:
- Proper handwashing and scrubbing methods, including the brush stroke technique of scrubbing nails, fingers, hands, and arms for the required duration.
- Gowning and gloving procedures to maintain sterility after scrubbing.
- Types of surgical scrubs including full, short, and indications for each.
- Operating room attire and restrictions for different zones to maintain asepsis.
1. The document discusses different types of anesthesia including general anesthesia which causes loss of consciousness and regional anesthesia which causes loss of sensation in one area while maintaining consciousness.
2. It describes various agents that can be used for anesthesia like opioids, barbiturates, benzodiazepines and different techniques for their administration including topical application, local infiltration, nerve blocks and spinal or epidural anesthesia.
3. The advantages of regional anesthesia are discussed versus general anesthesia.
This document lists complications that can occur from various drugs and anesthetics. It discusses potential side effects such as cardiac arrest, respiratory depression, hypotension, loss of protective pain response, vomiting, and malignant hyperthermia that require establishing an open airway, oxygen administration, and notifying the surgeon. It also covers prevention and intervention steps for issues like anaphylaxis, hypotension, nausea and vomiting, headaches, overdosage, and respiratory and neurological complications. Local and systemic side effects of local anesthetics are also outlined.
The document discusses various issues that may arise in labor and birth and their management, including:
1) Trial labor is used to determine if normal labor can progress with conditions like borderline pelvis, induction and augmentation are used to artificially start or assist stalled labor, and instrumental deliveries like forceps and vacuum can be used when pushing is ineffective.
2) Cesarean delivery is performed by making an abdominal and uterine incision when vaginal birth poses risks, and complications include infections, hemorrhage, and injury to mother or baby.
3) Postpartum complications are also reviewed like hematoma, infection, mastitis, thrombosis, and postpartum depression or psychosis.
Infertility is the inability to conceive a child or sustain a pregnancy, affecting 14% of couples. It can be primary (never conceived) or secondary (unable to conceive again). Male infertility can be caused by low sperm count, mobility issues, or ejaculation problems from infections, obesity, or medications. Female infertility can be due to cervical, vaginal, or ovulation issues from conditions like PCOS or thyroid problems. Diagnosis involves semen analysis, ovulation monitoring, and tests of fallopian tube patency. Treatment may include lifestyle changes, medication, surgery, assisted reproduction techniques like IVF, or alternatives like adoption.
This document provides an introduction to philosophy. It discusses how Pythagoras coined the term "philosophy" to describe those who seek wisdom rather than fame or wealth. Philosophy is defined as the love of wisdom and involves reflecting on topics like knowledge, God, life, death, human nature, ethics, and society through reason alone. The major branches of philosophy explore questions regarding the existence of God, the nature of knowledge, what it means to be human, free will, ethics, beauty, the meaning of life, and attainment of happiness.
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Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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• Pitfalls and pivots needed to use AI effectively in public health
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2. Microbial Diseases of the Urinary and Reproductive Systems Microbes usually enter the urinary system through the urethra. Microbes usually enter the reproductive system through the vagina (in females) or urethra (in males).
7. Normal Microbiota Urinary bladder and upper urinary tract sterile Lactobacilli predominant in the vagina >1,000 bacteria/ml or 100 coliforms/ml of urine indicates infection
8. Cystitis Usually caused by E. coli S. saprophyticus May also be caused by Proteus Klebsiella Enterococcus Pseudomonas E. coli usually causes pyelonephritis. Antibiotic-sensitivity tests may be required before treatment.
9. UTI Ureteritis = inflammation of ureter (maybe caused by stone in the ureter) Cystitis = inflammation of bladder (caused by ascending bacterial infection usually E. coli) Urethritis= inflammation of urethra (may lead to prostatitis and epididymitis)
11. FACTORS THAT CONTRIBUTE TO UTI FEMALE (PROXIMITY TO THE ANUS, SHORTER URETHRA) POOR HYGIENE UNSAFE SEXUAL PRACTICES BACK TO FRONT STROKE HIGH pH URINARY STASIS KIDNEY STONES OBSTRUCTION OF URINE OUTFLOW
12. S/Sx: PAIN assessment Pain during and after urination = cystitis Pain after urination = urethritis Inguinal pain = ureteritis Flank pain = pyelonephritis Inflammatory manifestations fever and chills Cx: Ascending infection Obstruction (stones/calculi)
13. Management E. coli (most common C.A.) Increase fluids Warm sitz bath EMPTY the bladder Good hygiene Observe safe sexual practice Front to back stroke Acidify urine (cranberry juice, prune, plums) C/S test before giving antibiotics For urosepsis give aminoglycosides Observe complications
14. Leptospirosis Leptospira interrogans Reservoir: Dogs and rats Transmitted by skin/mucosal contact from urine-contaminated water Diagnosis: Isolating bacteria or serological tests Figure 26.4
35. Gonorrhea Neisseria gonorrhoeae Attaches to oral or urogenital mucosa by fimbriae. Females may be asymptomatic; males have painful urination and pus discharge. Treatment is with antibiotics. If left untreated, may result in Endocarditis Meningitis Arthritis Ophthalmia neonatorum
38. Nongonococcal Urethritis Chlamydia trachomatis May be transmitted to a newborn's eyes Painful urination and watery discharge Mycoplasma hominis Ureaplasma urealyticum
41. SIGNS AND SYMPTOMS Females: usually asymptomatic or minimal urethral discharge w/ lower abdominal pain Male: Mucopurulent discharge, Painful urination 29 Rex Karl S. Teoxon, R.N, M.D
69. CHLAMYDIA Chlamydia trachomatis, gram (-) IP: 2-10 days 46 Rex Karl S. Teoxon, R.N, M.D
70. SIGNS AND SYMPTOMS Maybe asymptomatic Gray white discharge, Burning and itchiness at the urethral opening DX: Gram stain Antigen detection test on cervical smear Urinalysis 47 Rex Karl S. Teoxon, R.N, M.D
83. Syphilis Direct diagnosis Darkfield microscopic identification of bacteria Staining with fluorescent-labeled, monoclonal antibodies Indirect, serological diagnosis VDRL, RPR, ELISA test for reagin-type antibodies using cardiolipid (Ag) FTA-ABS tests for anti-treponemal antibodies
85. Syphilis Primary stage: Chancre at site of infection Secondary: Skin and mucosal rashes Latent period: No symptoms Tertiary: Gummas on many organs Congenital: Neurological damage Primary and secondary stages treated with penicillin
100. 10-90 days (usually 3-4 weeks) after initial contact the host mounts an inflammatory response at the site of inoculation resulting in the hallmark syphilitic lesion, called the chancre (usually painless)
131. DIAGNOSIS Dark-field examination of lesion- 1st and 2nd stage Non specific VDRL and RPR FTA-ABS Mgmt Primary and secondary - Pen G Tertiary - IV Pen G 85 Rex Karl S. Teoxon, R.N, M.D
132. Diagnostic Tests for Syphilis (Original Wasserman Test) NOTE: Treponemal antigen tests indicate experience with a treponemal infection, but cross-react with antigens other than T. pallidum ssp. pallidum. Since pinta and yaws are rare in USA, positive treponemal antigen tests are usually indicative of syphilitic infection.
133. SYPHILISTREATMENT Patient and sexual partner(s) should be treated Antibiotic therapy Penicillin – preferred in pregnancy Doxycycline Tetracycline
141. CHLAMYDIALGV STD caused by serovars L1, L2, L3 Common in Asia, Africa, South America, and the Caribbean Incubation period 3 days to 3 weeks Painless vesicleregional lymphaticsinguinal and femoral adenitis and proctitis
142. Chancroid (Soft Chancre) Haemophilus ducreyi Ulcer on genitalia May break through surface Infection of lymph nodes Treatment: Erythromycin and ceftriaxone
144. DIAGNOSIS Viral culture Pap smear (shows cellular changes) Tzanck smear (scraping of ulcer for staining) 94 Rex Karl S. Teoxon, R.N, M.D
145. MANAGEMENT Anti viral – acyclovir (zovirax) CX: Meningitis – mild and self limiting Neonatal infection (vaginal birth) Disseminated with liver involvement Encephalitis Skin, eyes, mouth 95 Rex Karl S. Teoxon, R.N, M.D
146. Genital Herpes Herpes simplex virus 2 (Human herpesvirus 2 or HHV–2) Neonatal herpes transmitted to fetus or newborns Recurrences from viruses latent in nerves Suppression: Acyclovir or valacyclovir
147. HERPES GENITALIS HSV 2 Envelop, icosahedral, dsDNA Latent – sacral nerve ganglia 97 Rex Karl S. Teoxon, R.N, M.D
151. SIGNS AND SYMPTOMS Painful sexual intercourse Painful vesicular lesions (cervix, vagina, perineum, glans penis) 101 Rex Karl S. Teoxon, R.N, M.D
152. Genital Warts Human papillomaviruses Treatment: Imiquimod to stimulate interferon HPV 16 causes cervical cancer and cancer of the penis. DNA test is needed to detect cancer-causing strains. Vaccination against HPV strains
153. GENITAL WARTS Condyloma Acuminatum HPV type 6 & 11, papilloma virus 103 Rex Karl S. Teoxon, R.N, M.D
154. SIGNS AND SYMPTOMS Single or multiple soft, fleshy painless growth of the vulva, vagina, cervix, urethra, or anal area, Vaginal bleeding, discharge, odor and dyspareunia DX: Pap smear-shows cellular changes (koilocytosis) Acetic acid swabbing (will whiten lesion) 104 Rex Karl S. Teoxon, R.N, M.D
159. MANAGEMENT Laser treatment is more effective CX: Neoplasia Neonatal laryngeal papillomatosis (vaginal birth) Rex Karl S. Teoxon, R.N, M.D 109
160. Candidiasis Candida albicans Grows on mucosa of mouth, intestinal tract, and genitourinary tract. NGU in males Vulvovaginal candidiasis Diagnosis is by microscopic identification and culture of yeast. Treatment: Clotrimazole or miconazole.
161. CANDIDIASIS Moniliasis (oral candidiasis) Vulvovaginal candidiasis Candida albicans (Yeast or fungus) 111 Rex Karl S. Teoxon, R.N, M.D
162. SIGNS AND SYMPTOMS Cheesy white discharge Extreme itchiness DX: KOH (wet smear indicate positive result) 112 Rex Karl S. Teoxon, R.N, M.D
167. Trichomoniasis Trichomonas vaginalis Found in semen or urine of male carriers Vaginal infection causes irritation and profuse discharge. Diagnosis is by microscopic identification of protozoan. Treatment: Metronidazole. Figure 26.15
169. SIGNS AND SYMPTOMS Females: itching, burning on urination, yellow gray frothy malodorous vaginal discharge, foul smelling Males: usually asymptomatic Dx: microscopic exam of vaginal discharge 119 Rex Karl S. Teoxon, R.N, M.D
179. HIV and AIDS Retrovirus (HIV1 & HIV2) Attacks and kills CD4+ lymphocytes (T-helper) Capable of replicating in the lymphocytes undetected by the immune system Immunity declines and opportunistic microbes set in No known cure Rex Karl S. Teoxon, R.N, M.D 129
181. MOT Sexual intercourse (oral, vaginal and anal) Exposure to contaminated blood, semen, breast milk and other body fluids Blood Transfusion IV drug use Transplacental Needle stick injuries 131 Rex Karl S. Teoxon, R.N, M.D
182. HIGH RISK GROUP Homosexual or bisexual Intravenous drug users BT recipients before 1985 Sexual contact with HIV+ Babies of mothers who are HIV+ Rex Karl S. Teoxon, R.N, M.D 132
184. SIGNS AND SYMPTOMS Acute viral illness (1 mo after initial exposure) – fever, malaise, lymphadenopathy Clinical latency – 8 yrs w/ no sx; towards end, bacterial and skin infections and constitutonal sx – AIDS related complex; CD4 counts 400-200 AIDS – 2 yrs; CD4 T lymphocyte < 200 w/ (+) ELISA or Western Blot and opportunistic infections 134 Rex Karl S. Teoxon, R.N, M.D
185. DIAGNOSIS HIV+ 2 consecutive positive ELISA and 1 positive Western Blot Test AIDS+ HIV+ CD4+ count below 200/ml 135 Rex Karl S. Teoxon, R.N, M.D
186. SIGNS AND SYMPTOMS Extreme fatigue Intermittent fever Night sweats Chills Lymphadenopathy Enlarged spleen Rex Karl S. Teoxon, R.N, M.D 136
187. SIGNS AND SYMPTOMS Anorexia Weight loss Severe diarrhea Apathy and depression PTB Kaposis sarcoma Pneumocystis carinii AIDS dementia 137 Rex Karl S. Teoxon, R.N, M.D