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Biosensors
    Anthony Carr
     Brett Gobe
    Ben LaPierre
What are biosensors?
   Detectors based on selective molecular
    components of plants or animals.
   Modern Biosensors evolved from 2 different
    disciplines
       Molecular Biology
       Information Technology.
   Offers a wide variety of applications.
       Medical
       Environmental
       Military / Law Enforcement
Evolution of the Medical
Biosensor
   Mid 1950’s - Leland C Clark invents an
    electrode that measures dissolved oxygen in
    the blood of patients undergoing surgery.
   He surrounded a platinum electrode and
    reference electrode with a plastic membrane
    permeable to gases. The voltage differential
    measured between the two gave the rate at
    which the oxygen was being diffused.
   Clark extended this electrode idea to include glucose
    sensors.
   However these never made their way into routine patient
    care. This was due to flaws in accuracy when clots
    formed around the electrode.
Required Characteristics
    Sensitivity               Utility
    Low detection limits      Field portability
    Cost                      Ruggedness
    Simplicity                Reproducibility
    Reliability               Ease of calibration
    Speed                     Stability
    Accuracy                  Room for
    Precision                  improvement
Biosensors
  Combine a biological compound with a
   transducer
  What is a transducer?
Flow Injection Analysis
(FIA)
  What is FIA?
Uses of Biosensors
  Environmental Monitoring
  Military
  Law Enforcement
  Medical
Present Applications of
Biosensors
  Medical Care (both clinical and
   laboratory use)
  The determination of food quality
  The detection of environmental
   pollutants
  Industrial Process Control
Applications (cont’d.)
   Biosensors in process control will be able to measure
    materials in the process flow of temperature, pressure
    and the acidity readings.
   The development of biosensors in industry can
    improve manufacturing techniques, which would allow
    for a wider range of sensing molecules to be
    produced at a cheaper rate.
   In the field of medicine, tumor cells are used as a
    biosensor to monitor chemotherapeutic drug
    susceptibilities.
   Biosensors also play a role in the manufacturing of
    pharmaceuticals and replacement organs such as an
    artificial pancreas for diabetics.
   It is found that biosensors are widely used in
    environmental testing by using a “flow-
    through” system to monitor wastewater (a
    flow-through system includes instruments
    using surface plasmon resonance).
   These censors are not only restricted to the
    use of molecules. Rather living
    microorganisms such as bacteria can be used
    to detect substances such as vitamin B12.
   Conclusively, biosensors play a part in the
    field of medicine, environmental quality, and
    industry mainly by identifying material and the
    degree of concentration present.
QUESTIONS?

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Uses of biosensors

  • 1. Biosensors Anthony Carr Brett Gobe Ben LaPierre
  • 2. What are biosensors?  Detectors based on selective molecular components of plants or animals.  Modern Biosensors evolved from 2 different disciplines  Molecular Biology  Information Technology.  Offers a wide variety of applications.  Medical  Environmental  Military / Law Enforcement
  • 3.
  • 4. Evolution of the Medical Biosensor  Mid 1950’s - Leland C Clark invents an electrode that measures dissolved oxygen in the blood of patients undergoing surgery.  He surrounded a platinum electrode and reference electrode with a plastic membrane permeable to gases. The voltage differential measured between the two gave the rate at which the oxygen was being diffused.
  • 5. Clark extended this electrode idea to include glucose sensors.  However these never made their way into routine patient care. This was due to flaws in accuracy when clots formed around the electrode.
  • 6. Required Characteristics  Sensitivity  Utility  Low detection limits  Field portability  Cost  Ruggedness  Simplicity  Reproducibility  Reliability  Ease of calibration  Speed  Stability  Accuracy  Room for  Precision improvement
  • 7. Biosensors  Combine a biological compound with a transducer  What is a transducer?
  • 8.
  • 9. Flow Injection Analysis (FIA)  What is FIA?
  • 10. Uses of Biosensors  Environmental Monitoring  Military  Law Enforcement  Medical
  • 11. Present Applications of Biosensors  Medical Care (both clinical and laboratory use)  The determination of food quality  The detection of environmental pollutants  Industrial Process Control
  • 12. Applications (cont’d.)  Biosensors in process control will be able to measure materials in the process flow of temperature, pressure and the acidity readings.  The development of biosensors in industry can improve manufacturing techniques, which would allow for a wider range of sensing molecules to be produced at a cheaper rate.  In the field of medicine, tumor cells are used as a biosensor to monitor chemotherapeutic drug susceptibilities.  Biosensors also play a role in the manufacturing of pharmaceuticals and replacement organs such as an artificial pancreas for diabetics.
  • 13. It is found that biosensors are widely used in environmental testing by using a “flow- through” system to monitor wastewater (a flow-through system includes instruments using surface plasmon resonance).  These censors are not only restricted to the use of molecules. Rather living microorganisms such as bacteria can be used to detect substances such as vitamin B12.  Conclusively, biosensors play a part in the field of medicine, environmental quality, and industry mainly by identifying material and the degree of concentration present.