This document summarizes the polio situation in the Eastern Mediterranean Region as of October 2021. It reports that Afghanistan and Pakistan continue to have cases of wild poliovirus type 1 and circulating vaccine-derived poliovirus type 2. Sudan has had an outbreak of cVDPV2 that may now be stopped, but cross-border risks remain. Somalia, Egypt, and Yemen also have had poliovirus outbreaks or events. The document discusses opportunities and risks in the region and ensuring polio assets transition smoothly to continue their sustainable impact.