This document summarizes the COVID-19 situation globally and in the Eastern Mediterranean region as of October 2020. It discusses key factors impacting COVID-19 transmission in the region like migrant workers, travel restrictions, fragility and conflict, mass gatherings, and demographics. It outlines achievements in expanding testing capacity, building on existing systems, and logistics support. It also notes challenges around IPC practices, lack of national programs, limited public health measures, and difficulty sustaining behavior changes. The document requests that ministers prioritize COVID-19 response, invest in health systems and preparedness, and engage all relevant sectors. It provides three recommendations for member states around implementing multi-sectoral plans, providing evidence-based public information,