This document outlines key concepts about the Expanded Programme for Immunization (EPI). It begins by defining important immunology terms like immunity, antigen, antibody, vaccine, and immunization. It then reviews the basic concepts of immunology, describing the innate and adaptive immune systems, including humoral and cell-mediated responses. The document introduces the EPI and discusses its objectives to describe immunization guidelines, schedules, target groups, vaccine administration and side effects. It concludes by differentiating between passive and active immunization.