The engagement of colleges and universities in their regional economies depends on forging collaborations. The task is tricky, because these collaborations often engage people who have never worked together. These partnerships form in the “civic space” outside the four walls of any one organization. In this civic space, no one can tell anyone else what to do. Strategic Doing presents a new approach to forming sophisticated collaborations quickly, guiding them toward measurable outcomes, and adjusting along the way. A number of universities are now deploying this discipline, as they develop collaborations, workforce innovations, and clusters.