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Biomanufacturing 2018

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Partnering to Advance Wisconsin as a Bio-manufacturing Hub.

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Biomanufacturing 2018

  1. 1. Partnering to Advance Wisconsin as a Biomanufacturing Hub Bill Murphy, Director Andy Richards, Director Lisa Johnson, CEO Thomas Tubon, Ph.D
  2. 2. Welcome to Wisconsin
  3. 3. The Path to Biomanufacturing Innovation TalentPlace
  4. 4. Stem Cell Discoveries at UW Madison Fundamental Breakthroughs 2012: Stem cell regulation in blood development 2003: Homologous recombination in stem cells 2013:Genome editing in stem cells 2012: Stem cell regulation in cancer 1998: Human Embryonic Stem Cells 1995: Primate Embryonic Stem Cells 2007: Human Induced Pluripotent Stem Cells
  5. 5. Stem Cell Discoveries at UW Madison Stem Cell Differentiation 2009: iPS cells to heart muscle cells2009: iPS cells to white blood cells 2009: Stem cells to retina cells 2014: Stem cells to muscle cells 2001: ES cells to neurons 2011: Stem cells to astrocytes 2005: ES cells to motor neurons 2003: ES cells to heart muscle cells 2013: Skin cells to neural progenitors
  6. 6. Stem Cell Discoveries at UW Madison 2011: Stem cells to retina 2012: Blood to retina 2014: Stem cells to blood 2014: Stem cells to developing brain From Stem Cells to Human Tissues 2013: Stem cells to bone-cartilage 2013: iPS cells to blood vessels 2012: Stem cells to blood-brain barrier
  7. 7. Stem Cell Discoveries at UW Madison Disease Models & Disease Treatments Diabetes 2003: Stem cells to pancreatic islets Neurodegenerative Diseases 2001: SC transplant to mouse brain “Personalized Medicine” 2013: iPS neurons in primate Amyotrophic Lateral Sclerosis 2007: Stem cells to GDNF+ neurons Degenerative Eye Diseases 2007: Stem cells to neural progenitors ALS Respiratory Failure 2013: Stem cells to neural progenitors Diseases of Memory/Learning 2013: iPS cells to GABA and cholinergic neurons Huntington’s Disease 2012: Stem cells – GABA neurons Spinal Muscular Atrophy 2008: iPS cells to neurons Best Disease 2012: iPS cells to retina cells Gyrate Atrophy 2012: Stem cells to retina cells Down Syndrome 2013: iPS cells to neurons Drug Toxicity 2007: Stem cells for tox. screening Rett Syndrome (Autism-Related) 2011: iPS cells to neurons
  8. 8. UW Stem Cell Research: by the Numbers Research Scope • 100 faculty • 30 departments spanning the UW campus • 200 current PhD students in training • 500 research articles published annually • $50M in federal funding annually “The ‘Mecca’ of stem cell research” - Irving Weissman, 2012 “The birthplace of regenerative medicine.” - Sir Ian Wilmut, 2007
  9. 9. Biomanufacturing Startups and Partners Cellular Logistics A series of groundbreaking stem cell discoveries led to the development of what we now know as the biomanufacturing industry
  10. 10. Wisconsin Center of Excellence Place, innovation, and talent spurring economic development
  11. 11. 11 Wisconsin – A Biomanufacturing Center of Excellence
  12. 12. 12 • Cell therapies • Engineered tissues • Pharmaceuticals • Medical devices • Drug discovery What is Biomanufacturing? Biomanufacturing is the use of advanced manufacturing approaches to design and produce the next generation of healthcare products.
  13. 13. 13 Comprehensive support of technological innovation Innovation Training Pre-incorporation IncubationIncubation MentoringMentoring Post-incorporationPost-incorporation Facilitating Partnerships Government Relations Marketing & Outreach
  14. 14. 14 A unique public-private collaboration committed to advancing the global biomanufacturing industry. •Training the next generation of innovators and entrepreneurs •Facilitating partnerships between government, academia and private industry •Translating discoveries into commercial products and groundbreaking therapies www.forwardbioinitiative.org Advancing Wisconsin’s Position as a National Leader
  15. 15. 15 A Shared Strategic Vision The Forward BIO Leadership Team Chair Vice-Chair Advisor Industry Engagement Lead Director CEOCo-founder Co-founder
  16. 16. 16 Join us and get involved! Donate to the Institute Support R&D and Workforce Projects Join Our Industry Consortium Sponsor Forward BIOLABSSponsor Forward BIOLABS Connect with Promising StartupsConnect with Promising Startups Mentor EntrepreneursMentor Entrepreneurs Join BioForward Member Involvement Promote Initiative forwardbio.wisc.edu forwardbiolabs.org bioforward.org www.forwardbioinitiative.org
  17. 17. 17 Catalyzing Innovation in Biomanufacturing Research, Entrepreneurship, and Workforce Development InnovationInnovation WorkforceWorkforce DevelopmentDevelopment IndustryIndustry PartnersPartners forwardbio.wisc.edu
  18. 18. Accelerating the growth of startups 18 Changing how life science companies are built Equipped &Equipped & SupportedSupported LabsLabs CollaborativeCollaborative EnvironmentEnvironment IndustryIndustry ConnectionsConnections
  19. 19. Advancing Industry Growth Promoting the growth of Wisconsin’s biohealth industry & defining the future of healthcare through leadership in integrated health solutions AdvocacyAdvocacy Marketing &Marketing & EducationEducation MemberMember Engagement &Engagement & CollaborationCollaboration www.bioforward.org
  20. 20. Consortium for Advanced Manufacturing of Cell & Tissue-based Products (CAMCTP) DIRECTIVE To formalize a comprehensive stakeholder network from community to career to support bio-economic growth and workforce development in the area of biomanufacturing for cell & tissue-based products.
  21. 21. • Institution of Origin: Madison Area Technical College • Prior Support: $5M in NSF Advanced Technological Education grant awards to develop Career Technical Education (CTE) programming in Biotechnology. • Merit: Madison College was first in the nation to start CTE programming in Biotech, CTE programming in Stem Cells, and seeks to pioneer CTE programming in cell manufacturing. • Strategic Plan: Multi-year initiative to map the ecosystem and create a community-to-career pathway for technical education in biomanufacturing. • Broader Impact: Over 200 Regional and National Partnerships, including: Consortium for Advanced Manufacturing of Cell & Tissue-based Products (CAMCTP)

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