This document discusses efforts in Wisconsin to establish the state as a leader in biomanufacturing. It outlines stem cell research discoveries at the University of Wisconsin-Madison dating back to the 1990s. These discoveries helped launch the biomanufacturing industry and startups in Wisconsin. The document then describes the Wisconsin Center of Excellence, a public-private collaboration committed to advancing biomanufacturing through innovation, workforce development, and industry partnerships. It provides an overview of initiatives like Forward BIO and the Consortium for Advanced Manufacturing of Cell & Tissue-based Products, which aim to catalyze innovation, support startups, and develop education programs in biomanufacturing.

1. Partnering to Advance Wisconsin as a
Biomanufacturing Hub
Bill Murphy, Director
Andy Richards, Director
Lisa Johnson, CEO
Thomas Tubon, Ph.D

2. Welcome to Wisconsin

3. The Path to Biomanufacturing
Innovation
TalentPlace

4. Stem Cell Discoveries at UW Madison
Fundamental Breakthroughs
2012: Stem cell regulation in blood development
2003: Homologous recombination in stem cells 2013:Genome editing in stem cells
2012: Stem cell regulation in
cancer
1998: Human Embryonic Stem Cells
1995: Primate Embryonic Stem Cells
2007: Human Induced Pluripotent Stem Cells

5. Stem Cell Discoveries at UW Madison
Stem Cell Differentiation
2009: iPS cells to heart muscle cells2009: iPS cells to white blood cells
2009: Stem cells to retina cells
2014: Stem cells to muscle cells
2001: ES cells to neurons
2011: Stem cells to astrocytes
2005: ES cells to motor neurons
2003: ES cells to heart muscle cells
2013: Skin cells to neural progenitors

6. Stem Cell Discoveries at UW Madison
2011: Stem cells to retina
2012: Blood to retina
2014: Stem cells to blood
2014: Stem cells to developing brain
From Stem Cells to Human Tissues
2013: Stem cells to bone-cartilage
2013: iPS cells to blood vessels
2012: Stem cells to blood-brain barrier

7. Stem Cell Discoveries at UW Madison
Disease Models & Disease Treatments
Diabetes
2003: Stem cells to pancreatic islets
Neurodegenerative Diseases
2001: SC transplant to mouse brain
“Personalized Medicine”
2013: iPS neurons in primate
Amyotrophic Lateral Sclerosis
2007: Stem cells to GDNF+ neurons
Degenerative Eye Diseases
2007: Stem cells to neural progenitors
ALS Respiratory Failure
2013: Stem cells to neural
progenitors
Diseases of Memory/Learning
2013: iPS cells to GABA and cholinergic neurons
Huntington’s Disease
2012: Stem cells – GABA neurons
Spinal Muscular Atrophy
2008: iPS cells to neurons
Best Disease
2012: iPS cells to retina cells
Gyrate Atrophy
2012: Stem cells to retina cells
Down Syndrome
2013: iPS cells to neurons
Drug Toxicity
2007: Stem cells for tox. screening
Rett Syndrome (Autism-Related)
2011: iPS cells to neurons

8. UW Stem Cell Research: by the Numbers
Research Scope
• 100 faculty
• 30 departments spanning the UW campus
• 200 current PhD students in training
• 500 research articles published annually
• $50M in federal funding annually
“The ‘Mecca’ of stem cell research”
- Irving Weissman, 2012
“The birthplace of regenerative medicine.”
- Sir Ian Wilmut, 2007

9. Biomanufacturing Startups and Partners
Cellular Logistics
A series of groundbreaking stem cell discoveries led to the development of
what we now know as the biomanufacturing industry

10. Wisconsin Center of Excellence
Place, innovation, and talent spurring
economic development

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Wisconsin –
A Biomanufacturing
Center of Excellence

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• Cell therapies
• Engineered tissues
• Pharmaceuticals
• Medical devices
• Drug discovery
What is Biomanufacturing?
Biomanufacturing is the use of advanced
manufacturing approaches to design and produce
the next generation of healthcare products.

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Comprehensive support of technological innovation
Innovation
Training
Pre-incorporation
IncubationIncubation
MentoringMentoring
Post-incorporationPost-incorporation
Facilitating Partnerships
Government Relations
Marketing & Outreach

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A unique public-private collaboration committed to
advancing the global biomanufacturing industry.
•Training the next generation of innovators and
entrepreneurs
•Facilitating partnerships between government,
academia and private industry
•Translating discoveries into commercial products and
groundbreaking therapies
www.forwardbioinitiative.org
Advancing Wisconsin’s
Position as a National Leader

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A Shared Strategic Vision
The Forward BIO Leadership Team
Chair Vice-Chair Advisor
Industry
Engagement Lead
Director CEOCo-founder Co-founder

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Join us and get involved!
Donate to the Institute
Support R&D and Workforce Projects
Join Our Industry Consortium
Sponsor Forward BIOLABSSponsor Forward BIOLABS
Connect with Promising StartupsConnect with Promising Startups
Mentor EntrepreneursMentor Entrepreneurs
Join BioForward
Member Involvement
Promote Initiative
forwardbio.wisc.edu forwardbiolabs.org bioforward.org
www.forwardbioinitiative.org

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Catalyzing Innovation in Biomanufacturing
Research, Entrepreneurship, and
Workforce Development
InnovationInnovation
WorkforceWorkforce
DevelopmentDevelopment
IndustryIndustry
PartnersPartners
forwardbio.wisc.edu

18. Accelerating the growth of startups
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Changing how life science companies are built
Equipped &Equipped &
SupportedSupported
LabsLabs
CollaborativeCollaborative
EnvironmentEnvironment
IndustryIndustry
ConnectionsConnections

19. Advancing Industry Growth
Promoting the growth of Wisconsin’s biohealth
industry & defining the future of healthcare through
leadership in integrated health solutions
AdvocacyAdvocacy
Marketing &Marketing &
EducationEducation
MemberMember
Engagement &Engagement &
CollaborationCollaboration
www.bioforward.org

20. Consortium for Advanced Manufacturing of Cell & Tissue-based
Products (CAMCTP)
DIRECTIVE
To formalize a comprehensive stakeholder network from community to career
to support bio-economic growth and workforce development in the area of
biomanufacturing for cell & tissue-based products.

21. • Institution of Origin: Madison Area Technical College
• Prior Support: $5M in NSF Advanced Technological Education grant
awards to develop Career Technical Education (CTE) programming in
Biotechnology.
• Merit: Madison College was first in the nation to start CTE programming in
Biotech, CTE programming in Stem Cells, and seeks to pioneer CTE
programming in cell manufacturing.
• Strategic Plan: Multi-year initiative to map the ecosystem and create a
community-to-career pathway for technical education in biomanufacturing.
• Broader Impact: Over 200 Regional and National Partnerships, including:
Consortium for Advanced Manufacturing of Cell & Tissue-based
Products (CAMCTP)