MEDLINE is a literature database of biomedical information introduced in 1971 and maintained by the United States National Library of Medicine. It includes over 6,000 biomedical journals that are indexed and searchable via PubMed. MEDLINE began as MEDLARS, a computerized storage and retrieval system operated by the NLM since 1964 to index and provide access to medical literature. It has evolved to include additional databases and online services like PubMed and MedlinePlus.