Turmeric is a perennial plant native to South Asia. Its root contains the active compound curcumin, which makes up 3-5% of the root and has powerful anti-inflammatory and antioxidant effects. Curcumin has been shown to inhibit cancer cell growth in multiple types of cancer including breast, skin, stomach, and colon cancer by neutralizing carcinogens, inhibiting enzymes involved in cancer growth, and blocking blood vessel formation in tumors. Turmeric and its curcumin compound have many other health benefits such as reducing cholesterol and protecting against chronic diseases like heart disease, arthritis, and Alzheimer's.
Igennus are excited to announce the launch of our new product, Longvida® Curcumin. During this webinar, Dr Bailey reviews the research behind the therapeutic use of curcumin and why Longvida is the world’s most advanced formulation of the nutrient.
Curcumin is a polyphenol compound obtained from the rhizome of Curcuma longa, also known as turmeric. This Indian spice has a long history of use in Ayurvedic medicine as a treatment for inflammatory conditions. Curcumin is well documented for its antioxidant, anti-inflammatory and anti-cancer activities. Although it has been shown to be safe at high doses (12g/d), it is poorly absorbed, undergoes rapid intestinal and hepatic metabolism and is rapidly eliminated from the body. As such, standard curcumin demonstrates poor bioavailability, even at high doses, limiting its therapeutic potential.
After much research and discussion (it’s a big and complicated topic!) between the Igennus nutrition scientists, the decision as to which type of curcumin we would use for our Synergistic Nutrients range was actually a very straightforward one. Longvida Curcumin utilises a novel delivery system (SLCP), which protects curcumin from the harsh environment of the stomach and promotes its rapid absorption into the bloodstream and target tissues, even at low doses – resulting in an incredible 285x superior bioavaibility compared with standard curcumin, 65x higher peak plasma levels and 7x longer-lasting action. Longvida is the only formulation proven to deliver high levels of free form, unconjugated curcumin, into the bloodstream. Free form curcumin is the form required for therapeutic benefits, and the only form proven to cross the blood brain barrier.
This webinar covers:
- What curcumin is, what it does and how?
- Why free form curcumin is essential for therapeutic effects
- The research and current evidence for Longvida Curcumin’s unique health benefits
- How Longvida overcomes significant bioavailability issues associated with curcumin use
- To who, why and when you should recommend curcumin
…and more.
Turmeric used in cooking across the globe in various dishes is world's best known anti-cancer superfood. This presentation gives an overview on the same and enlisted a few dishes for healthy non-cancerous life on the occasion of "World No Tobacco Day"
Igennus are excited to announce the launch of our new product, Longvida® Curcumin. During this webinar, Dr Bailey reviews the research behind the therapeutic use of curcumin and why Longvida is the world’s most advanced formulation of the nutrient.
Curcumin is a polyphenol compound obtained from the rhizome of Curcuma longa, also known as turmeric. This Indian spice has a long history of use in Ayurvedic medicine as a treatment for inflammatory conditions. Curcumin is well documented for its antioxidant, anti-inflammatory and anti-cancer activities. Although it has been shown to be safe at high doses (12g/d), it is poorly absorbed, undergoes rapid intestinal and hepatic metabolism and is rapidly eliminated from the body. As such, standard curcumin demonstrates poor bioavailability, even at high doses, limiting its therapeutic potential.
After much research and discussion (it’s a big and complicated topic!) between the Igennus nutrition scientists, the decision as to which type of curcumin we would use for our Synergistic Nutrients range was actually a very straightforward one. Longvida Curcumin utilises a novel delivery system (SLCP), which protects curcumin from the harsh environment of the stomach and promotes its rapid absorption into the bloodstream and target tissues, even at low doses – resulting in an incredible 285x superior bioavaibility compared with standard curcumin, 65x higher peak plasma levels and 7x longer-lasting action. Longvida is the only formulation proven to deliver high levels of free form, unconjugated curcumin, into the bloodstream. Free form curcumin is the form required for therapeutic benefits, and the only form proven to cross the blood brain barrier.
This webinar covers:
- What curcumin is, what it does and how?
- Why free form curcumin is essential for therapeutic effects
- The research and current evidence for Longvida Curcumin’s unique health benefits
- How Longvida overcomes significant bioavailability issues associated with curcumin use
- To who, why and when you should recommend curcumin
…and more.
Turmeric used in cooking across the globe in various dishes is world's best known anti-cancer superfood. This presentation gives an overview on the same and enlisted a few dishes for healthy non-cancerous life on the occasion of "World No Tobacco Day"
HALDI BIOLOGICALLY KNOWN AS CURCUMA LONGA AND COMMONLY TURMERIC ITS PHARMACOGNOSY IS DISCUSSED HERE ALSO WHERE IT IS GROW AT HIGHER AND ITS MEDICINAL USES AND FORMULATION AVAILABLE IN MARKET.
Curcumin, the compound responsible for the yellow color of turmeric has much more to offer than just its color. Curcumin comes with a plethora of health benefits which makes it a hot topic in the nutraceutical industry. Unleash the world of curcumin and see the reasons why you need to spice it up!
Turmeric (nature’s precious gift) is a plant that has a very long history of
medicinal use, dating back nearly 4000 years.
• In Southeast Asia, turmeric is used not only as a principal spice but also as a component in religious ceremonies. Because of its brilliant yellow color, turmeric is also known as “Indian saffron.”
• Modern medicine has begun to recognize its importance, as indicated by the over 3000 publications dealing with turmeric that came out within the last 25 years.
• Tamil Nadu, is the world’s largest producer of and the most important trading center for turmeric. It is also known as “Yellow City,” “Turmeric City,” or “Textile City.”
Ayurveda Herbs : Medicinal uses of Turmeric
Ayurveda, the Indian System of Medicine, uses TURMERIC as medicine since centuries. The herb is very effective in many disease conditions. This is also a household remedy in India and in Indian Continents. Details are given about the medicinal properties of this Herb,with its uses.
Turmeric used in cooking across the globe in various dishes is world's best known anti-cancer superfood. This presentation gives an overview on the same and enlisted a few dishes for healthy non-cancerous life on the occasion of "World No Tobacco Day"
Cloves are the aromatic flower buds of a tree in the family Myrtaceae, Syzygium aromaticum. They are native to the Maluku Islands in Indonesia, and are commonly used as a spice. Cloves are commercially harvested primarily in Indonesia, India, Madagascar, Zanzibar, Pakistan, Sri Lanka and Tanzania.
1. Pharmacognostic profile of Fenugreek
2. Macroscopy
3. General uses and Common names of fenugreek
4. Health benefits
5. Nutraceutical properties
6. Medicinal uses of fenugreek
7. Doses & Adverse effects
8. Formulations
9. Thank you
Spice as Medicine: Coriander & Cilantro, Coriandrum sativumKevin KF Ng
Coriander and cilantro have been used as spice and medicine for thousands of years. Modern science has uncovered their bioactive compounds which are beneficial for health
HALDI BIOLOGICALLY KNOWN AS CURCUMA LONGA AND COMMONLY TURMERIC ITS PHARMACOGNOSY IS DISCUSSED HERE ALSO WHERE IT IS GROW AT HIGHER AND ITS MEDICINAL USES AND FORMULATION AVAILABLE IN MARKET.
Curcumin, the compound responsible for the yellow color of turmeric has much more to offer than just its color. Curcumin comes with a plethora of health benefits which makes it a hot topic in the nutraceutical industry. Unleash the world of curcumin and see the reasons why you need to spice it up!
Turmeric (nature’s precious gift) is a plant that has a very long history of
medicinal use, dating back nearly 4000 years.
• In Southeast Asia, turmeric is used not only as a principal spice but also as a component in religious ceremonies. Because of its brilliant yellow color, turmeric is also known as “Indian saffron.”
• Modern medicine has begun to recognize its importance, as indicated by the over 3000 publications dealing with turmeric that came out within the last 25 years.
• Tamil Nadu, is the world’s largest producer of and the most important trading center for turmeric. It is also known as “Yellow City,” “Turmeric City,” or “Textile City.”
Ayurveda Herbs : Medicinal uses of Turmeric
Ayurveda, the Indian System of Medicine, uses TURMERIC as medicine since centuries. The herb is very effective in many disease conditions. This is also a household remedy in India and in Indian Continents. Details are given about the medicinal properties of this Herb,with its uses.
Turmeric used in cooking across the globe in various dishes is world's best known anti-cancer superfood. This presentation gives an overview on the same and enlisted a few dishes for healthy non-cancerous life on the occasion of "World No Tobacco Day"
Cloves are the aromatic flower buds of a tree in the family Myrtaceae, Syzygium aromaticum. They are native to the Maluku Islands in Indonesia, and are commonly used as a spice. Cloves are commercially harvested primarily in Indonesia, India, Madagascar, Zanzibar, Pakistan, Sri Lanka and Tanzania.
1. Pharmacognostic profile of Fenugreek
2. Macroscopy
3. General uses and Common names of fenugreek
4. Health benefits
5. Nutraceutical properties
6. Medicinal uses of fenugreek
7. Doses & Adverse effects
8. Formulations
9. Thank you
Spice as Medicine: Coriander & Cilantro, Coriandrum sativumKevin KF Ng
Coriander and cilantro have been used as spice and medicine for thousands of years. Modern science has uncovered their bioactive compounds which are beneficial for health
Curcumin for Cancer Prevention & Cure 09370322999Shibu Thankachan
Call 09370322999 to knore more on our product Curcumin C3 Power™ which is the best solution for Cancer prevention
Cancer is a term used for a broad group of diseases involving unregulated cell growth. There are more than hundred types of cancerous growth of cells that can affect almost any part of the body including brain, lung, breast, skin, blood, colon or cervix.
Up to 40% of all cancer deaths can be prevented by eliminating tobacco use, improving diets and physical activity, lowering alcohol consumption, eliminating workplace carcinogens and immunizing against Hepatitis B virus and human papillomavirus. Also a large proportion of cancer can be cured if detected early.
Lot of Researches have shown that Curcumin the active ingredient in turmeric has emerged as a potent multimodal cancer-preventing agent. Daily intake of required amount of Curcumin can go a long way in preventing cancer
Le curcuma est une plante herbacée vivace originaire du sud de l'Asie. Son rhizome séché et réduit en poudre est une épice très populaire. Le curcuma, nommé haridra en sanscrit, est un des principaux ingrédients du cari, un mélange d'épices omniprésent dans la cuisine indienne. En Asie, on a depuis longtemps découvert qu’ajouter du curcuma aux aliments permettait de conserver leur fraîcheur, leur saveur et leur valeur nutritive.
Ainsi, bien avant l'époque des conservateurs synthétiques, le curcuma jouait un rôle primordial comme additif alimentaire. Son nom chinois, Jianghuang, signifie « gingembre jaune », une allusion à sa ressemblance avec le gingembre, une plante de la même famille, et à la remarquable couleur de son rhizome qu'on a utilisé comme colorant et teinture.
En médecine ayurvédique (médecine traditionnelle de l'Inde), de même que dans les médecines traditionnelles de la Chine, du Japon, de la Thaïlande et de l'Indonésie, le curcuma est utilisé pour stimuler la digestion, notamment parce qu’il augmente la sécrétion biliaire. En fait, ces propriétés sont universellement reconnues, si bien que le rhizome est commercialisé dans le monde entier.
Au cours des dernières décennies, on a isolé, dans les rhizomes du curcuma, des substances auxquelles on a donné le nom de curcuminoïdes (la curcumine constitue environ 90 % de ces composés). Il s'agit d'antioxydants très puissants, qui pourraient expliquer un certain nombre des indications médicinales traditionnelles de cette plante, notamment pour le traitement de divers troubles inflammatoires dont les douleurs rhumatismales ou menstruelles. En Asie et en Inde, il est également utilisé de façon topique pour accélérer la guérison des ulcères, des blessures ainsi que des lésions causées par la gale et l’eczéma, par exemple.
Traitement du cancer. Les propriétés anticancéreuses de la curcumine sont prises très au sérieux par la communauté scientifique et plusieurs essais cliniques sont en cours27. Jusqu’à présent, on ne dispose que de peu de résultats, mais ils sont encourageants. Utilisée seule ou en association avec la chimiothérapie, la curcumine (8 g par jour) a permis, dans quelques cas, de stabiliser l’évolution du cancer du pancréas23,42 . Cet effet a également été observé chez des patients souffrant de cancer colorectal43.
Ces études préliminaires ont toutefois confirmé ce que les études avec l’animal avait révélé : la biodisponibilité de la curcumine est très faible 22,23,44. Elle est peu absorbée par les intestins et la fraction absorbée est rapidement transformée par le foie et éliminée. Les quantités qui se sont révélées efficaces dans les expériences in vitro sont donc difficiles à atteindre dans l’organisme19. C’est une des raisons pour laquelle les essais cliniques utilisent des doses si importantes et se focalisent sur les cancers du tube digestif où les quantités de curcumine demeurent élevées.
The Benefits of Turmeric (and 12 Practical Uses)Katie Wells
Turmeric: 12 Practical Uses for this Powerful Spice
Turmeric is a common cooking spice with some powerful health promoting properties! Find out 12 ways to incorporate it into your daily life and routine.
Cancer is the most evil of illnesses. It has only objective - to finish you off in the fastest time possible. And it usually succeeds.
But the reality is that in many cases, cancer does not find us. We invite cancer, by doing things we should not be doing...
This is a presentation which was sent to me by a friend. Being a topic which remains a perennial cause of concern I felt that I should share it with everyone - hence this upload.
Excellent presentation on cancer
A book written by Professor Richard Beliveau and Dr Denis Ginger on “foods to fight cancer” have the following findings:
Statistic shows that one out of three people is affected by cancer before the age of 75
This represents 12 per cent of all reported deaths on Earth.
However, fear not, there is hope.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
2. About the PlantAbout the Plant
Perennial
Relative of Ginger
Trumpet shape, dull yellow
flowers
Can grow 5-6 feet
Native to South Asia. Often
grown in India, Nepal and
China.
3. Active Ingredient:Active Ingredient:
CurcuminCurcumin
The root and rootstock, or rhizome, of the plant contain
the active ingredient.
3%-5% of the root has active ingredient1
It is an antioxidant
Studies have been done with 3.5-10 grams to inhibit and
prevent cancer cell growth1
Anti-inflammatory effects have been shown to be
comparable to the potent drugs hydrocortisone and
phenylbutazone as well as over-the-counter anti-
inflammatory agents such as Motrin
4. Curcumin ExtractionCurcumin Extraction 66
Plant is grown
Rhizome harvested
Solvent is created using polar solvent (acetone,
methanol, ethanol, ethyl acetate)
To remove color:
Freeze
Centrifuge or vacuum filtration
Purified with a hexane wash
5. Cancer PreventionCancer Prevention
Neutralizes substances and conditions that cause cancer. 3
Helps cells retain integrity if infected by carcinogen. 3
Curcumin can destroy tumor growth. 1,3
Possibly inhibits synthesis of protein that causes tumor growth and preventing development
of additional blood supply necessary for cell growth.1
Tumors of esophagus, mouth, intestines, stomach, breast and skin
In animal testing, cancer growth is slowed, inhibited and mass reduced1
Can inhibit enzyme growth of Topoisomerase.3
Topoisomerase works within the nucleus of the cell, where it first binds to supercoiled DNA
and then catalyzes the passage of one DNA helix through another via a transient double-
stranded break. This splits the DNA and thus allows cell replication to occur. Stopping
Topoisomerase stops replication which stops the spread of the problem.4
Natural COX-2 inhibitor3
Block an enzyme called cyclooxygenase-2. This is beneficial because the COX-2 enzyme
helps make carcinogens more active in the body and allows cancerous cells to survive by
growing new blood vessels. 5
Colon cells protected from free radical that damage DNA because of curcumin's
antioxidant actions.3
6. Effects on the BodyEffects on the Body
Stimulates galbladder
Stimulates circulatory system
Reduces cholesterol levels
Dissolves blood clots
Stops external and internal bleeding
Relieves painful menstration and angina
Remedy for IBS, colitis, Chron’s disease
Reduces illness from toxins and parasites and bacteria
Curcumin enhances liver function
7. Effects on the BodyEffects on the Body
In colon, cells turn over ever 3 days, making this a high risk for cancer
cell reproduction.1
When used in combination with phenethyl isothiocyanate (found in
cruciferous vegetables such as broccoli, cabbage, Brussels sprouts, kale,
kolhrabi and turnips) reduced tumor growth and the ability of prostate
cancer cells to spread in test animals.
Nagabhushan has shown that the curcumin in turmeric can2
:
inhibit the mutagenicity of polycyclic aromatic hydrocarbons (PAHs)
(carcinogenic chemicals created by the burning of carbon based fuels
including cigarette smoke)
inhibit radiation-induced chromosome damage
prevent the formation of harmful heterocyclic amines and nitroso
compounds, which may result in the body when certain processed foods,
such as processed meat products that contain nitrosamines, are eaten
irreversibly inhibit the multiplication of leukemia cells in a cell culture
8. Drug InformationDrug Information
Available Forms (dose)
Root or rhizome (1.5-3 g/day)
Traditional Powder (often used for cooking)
(1-3g per day)
Capsuels containing standardized powder
(400-600mg, 3 times per day)
Fluid extract (antibacterial oil) (1:1 30-90
drops/day)
Tincture (1:2 15-30 drops 4 times/day)
Topical (as needed)
Bromelain (from pineapples) often used in
combination
Turmeric or Curcumin with Cruciferous
Vegetables or their sprouts is very effective.
Drug Interactions
Blood thinning medications
Warfarin (Coumadin)
Clopidogrel (Plavix)
Aspirin
Drugs that reduce stomach acid
Cimetidine (Tagamet)
Famotidine (Pepcid)
Ranitidine (Zantac)
Esomeprazole (Nexium)
Omeprazole
Lansoprazole (Prevacid)
Diabetes medication
Make effects stronger – lowering
blood sugar
9. Additional ResearchAdditional Research
OpportunitiesOpportunities
1. Holistic health studies on nutrition and cancer prevention.
2. Food combinations and maximum cancer prevention.
3. HIV and AIDS reduction research.
4. Holistic plant treatment vs. curcumin use (whole rizome versus
extract).
5. Other ways to extract curcumin.
6. Reducing impact of cancer causing external influences.
10. Other UsesOther Uses
Rheumatoid Arthritis
Cystic Fibrosis Sufferers
Alzheimer's
Stomach Ulcers
Studied to prevent ‘bad cholesterol’
Used to improve kidney transplants
Pain relief
Food preservation
Toothache
Bruises
Lower Cholesterol
500 mg of curcumin taken for 7
days with a oxidized cholesterol
drop of 33% in blood, with total
cholesterol drop of 11% and HDL
increased by 29% 2
Interferes with some viruses: Hepititus
HIV Inhibition
When HIV cells were fed in a
laboratory in Bangalor, India, cells
stopped reproducing. Harvard
Medical School Study showed that
curcumin blocked a specific gene
that activates virus and causes it to
spread. Antimicrobial properties
protect maleffects from HIV (NPD
in Vermont). 3
Flatulence
Jaundice
Menstrual difficulties
Bloody urine
Hemorrhage
Chest pain
Colic
11. 20 reasons to add turmeric20 reasons to add turmeric
to your diet:to your diet:
1. It is a natural antiseptic and antibacterial agent, useful in disinfecting cuts and burns.
2. When combined with cauliflower, it has shown to prevent prostate cancer and stop the growth of existing prostate
cancer.
3. Prevented breast cancer from spreading to the lungs in mice.
4. May prevent melanoma and cause existing melanoma cells to commit suicide.
5. Reduces the risk of childhood leukemia.
6. Is a natural liver detoxifier.
7. May prevent and slow the progression of Alzheimer's disease by removing amyloyd plaque buildup in the brain.
8. May prevent metastases from occurring in many different forms of cancer.
9. It is a potent natural anti-inflammatory that works as well as many anti-inflammatory drugs but without the side
effects.
10. Has shown promise in slowing the progression of multiple sclerosis in mice.
11. Is a natural painkiller and cox-2 inhibitor.
12. May aid in fat metabolism and help in weight management.
13. Has long been used in Chinese medicine as a treatment for depression.
14. Because of its anti-inflammatory properties, it is a natural treatment for arthritis and rheumatoid arthritis.
15. Boosts the effects of chemo drug paclitaxel and reduces its side effects.
16. Promising studies are underway on the effects of turmeric on pancreatic cancer.
17. Studies are ongoing in the positive effects of turmeric on multiple myeloma.
18. Has been shown to stop the growth of new blood vessels in tumors.
19. Speeds up wound healing and assists in remodeling of damaged skin.
20. May help in the treatment of psoriasis and other inflammatory skin conditions.
(From: http://www.healthdiaries.com/eatthis/20-health-benefits-of-turmeric.html)