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Trigeminal neuralgia
Moderated by: Dr. Vidhi Rathi
Presented by: Gauri Bargoti
NEURALGIA
Pain of severe throbbing or stabbing
character in the course of distribution of a
nerve.
TRIGEMINAL NEURALGIA
• Trigeminal neuralgia (TN) is sudden,
usually unilateral, severe, brief, stabbing,
recurrent episodes of pain in the
distribution of one or more branches of
the trigeminal nerve.
SYNONYMS
• Trifacial neuralgia
• Fothergill’s disease
• Tic-doloureux (painful jerking)
ETOIOLOGY
• INTRACRANIAL CAUSES
1. Petrous ridge compression-internal carotid artey
pulsations
2. Multiple sclerosis
3. Intracranial tumors- at the cerebellopontine angle
4. Intracranial vascular abnormalities-basilar artery
aneurysm, superior cerebellar artery abnormality
• EXTRACRANIAL CAUSES
1. Vascular factors
2. Dental etiology
3. Post traumatic neuralgia
4. Infections
5. Viral etiology
• Neuralgias and neuritis
• Syphilis
• Tuberculosis
• Tumor of the brain
• Basilar meningitis
• Pontine diseases .
• Skull fracture
• Aneurysm of the carotid
artery or circle of willis
• Psychoneuroses,and
• Cavernous sinus
thrombosis
Other disorders that may affect the trigeminal
nerve include :
TYPES OF TRIGEMINAL
NEURALGIA
• Pre Trigeminal neuralgia
• Idiopathic Trigeminal neuralgia
• Symptomatic neuralgia
• Pre trigeminal neuralgia: dull aching
pain usually observed before appearance
of trigeminal neuralgia
• Idopathic neuralgia: where the etiology
remains unknown
• Symptomatic neuralgia: the type in
which the etiology is known
CLINICAL FEATURES
• Incidence : 4 in 1,00,000
• Age : 4th to 5th decade
• Sex : F>M
• 60% on the right side, 3%
bilateral.
• Mean age of onset-52-58yrs
Involvement : maxillary-60%
mandibular-49%
ophthalmic-16%
all 3 divisions-1%
• Manifests as sudden, unilateral,
intermittent, paroxysmal, sharp,
shooting, lancinating pain,
elicited by slight touch.
• Patient usually complains of
electric shock/lightening like
pain
• Usually confined to one part.
• Lasts for few seconds to
minutes.
• Motionless or mask like face.
• Rarely crosses the midline.
• Trigger points - Spontaneous attack or
triggered by trigger zone or movement of the
face as in chewing, talking, brushing or
yawning
• This leads patient frequently go unshaven or
unwashed
• Paroxysms occur in cycles.
• Depression and weight loss
Trigger zones are usually located on vermillion
border of lip, ala of the nose, cheek, chin, and
around the eye.
• There is generally no evidence of sensory
or motor impairment
• Apart from pain the other features are
itching & sensitivity of the face
• Rarely trigeminal neuralgia is associated
with hemi facial spasm- a condition called
TIC CONVULSIF that involves both V &
VII cranial nerves
DIAGNOSIS
•
•
•
•
•
•
History
Trigeminal nerve examination
Diagnostic nerve blocking
MRI (brain)
EEG
Microneurography
DIFFERENTIAL DIAGNOSIS
•
•
•
•
•
•
•
•
•
Post herpetic neuralgia
Dental pain
Post traumatic neuralgia
Multiple sclerosis
Glossopharyngeal neuralgia
Migraine
SUNCT syndrome (sudden unilateral neuralgia type of
pain with conjunctival involvement)
Migraine
Tumors of nasopharynx( trotter`s syndrome)
MANAGEMENT
• PHARMACOLOGICAL
• SURGICAL
• OTHERS
PHARMACOLOGICAL
•
•
•
FIRST LINE OF APPROACH
Carbamazepine 100, 200mg..
SECOND LINE OF APPROACH
Phenytoin 100mg
Baclofen 5-80 mg/day
Lamotrigine 25 mg/day
THIRD LINE OF APPROACH
Clonazepam 4-8 mg
Valproic acid 250-500 mg
Oxcarbazepine 1200mg/day
Other methods used are
• Trichloro ethylene inhalation
• Topical capsaicin cream application
• Proparacaine 0.5% anaesthetic drops in eye
• Anti inflammatory drug-Indomethacin & short
courses of steroids are found useful in some
cases

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trigeminal neuralgia

  • 1. Trigeminal neuralgia Moderated by: Dr. Vidhi Rathi Presented by: Gauri Bargoti
  • 2. NEURALGIA Pain of severe throbbing or stabbing character in the course of distribution of a nerve.
  • 3. TRIGEMINAL NEURALGIA • Trigeminal neuralgia (TN) is sudden, usually unilateral, severe, brief, stabbing, recurrent episodes of pain in the distribution of one or more branches of the trigeminal nerve.
  • 4. SYNONYMS • Trifacial neuralgia • Fothergill’s disease • Tic-doloureux (painful jerking)
  • 5. ETOIOLOGY • INTRACRANIAL CAUSES 1. Petrous ridge compression-internal carotid artey pulsations 2. Multiple sclerosis 3. Intracranial tumors- at the cerebellopontine angle 4. Intracranial vascular abnormalities-basilar artery aneurysm, superior cerebellar artery abnormality
  • 6. • EXTRACRANIAL CAUSES 1. Vascular factors 2. Dental etiology 3. Post traumatic neuralgia 4. Infections 5. Viral etiology
  • 7. • Neuralgias and neuritis • Syphilis • Tuberculosis • Tumor of the brain • Basilar meningitis • Pontine diseases . • Skull fracture • Aneurysm of the carotid artery or circle of willis • Psychoneuroses,and • Cavernous sinus thrombosis Other disorders that may affect the trigeminal nerve include :
  • 8.
  • 9.
  • 10. TYPES OF TRIGEMINAL NEURALGIA • Pre Trigeminal neuralgia • Idiopathic Trigeminal neuralgia • Symptomatic neuralgia
  • 11. • Pre trigeminal neuralgia: dull aching pain usually observed before appearance of trigeminal neuralgia • Idopathic neuralgia: where the etiology remains unknown • Symptomatic neuralgia: the type in which the etiology is known
  • 12. CLINICAL FEATURES • Incidence : 4 in 1,00,000 • Age : 4th to 5th decade • Sex : F>M • 60% on the right side, 3% bilateral. • Mean age of onset-52-58yrs
  • 14. • Manifests as sudden, unilateral, intermittent, paroxysmal, sharp, shooting, lancinating pain, elicited by slight touch. • Patient usually complains of electric shock/lightening like pain • Usually confined to one part. • Lasts for few seconds to minutes. • Motionless or mask like face.
  • 15. • Rarely crosses the midline. • Trigger points - Spontaneous attack or triggered by trigger zone or movement of the face as in chewing, talking, brushing or yawning • This leads patient frequently go unshaven or unwashed • Paroxysms occur in cycles. • Depression and weight loss
  • 16. Trigger zones are usually located on vermillion border of lip, ala of the nose, cheek, chin, and around the eye.
  • 17.
  • 18. • There is generally no evidence of sensory or motor impairment • Apart from pain the other features are itching & sensitivity of the face • Rarely trigeminal neuralgia is associated with hemi facial spasm- a condition called TIC CONVULSIF that involves both V & VII cranial nerves
  • 20. DIFFERENTIAL DIAGNOSIS • • • • • • • • • Post herpetic neuralgia Dental pain Post traumatic neuralgia Multiple sclerosis Glossopharyngeal neuralgia Migraine SUNCT syndrome (sudden unilateral neuralgia type of pain with conjunctival involvement) Migraine Tumors of nasopharynx( trotter`s syndrome)
  • 22. PHARMACOLOGICAL • • • FIRST LINE OF APPROACH Carbamazepine 100, 200mg.. SECOND LINE OF APPROACH Phenytoin 100mg Baclofen 5-80 mg/day Lamotrigine 25 mg/day THIRD LINE OF APPROACH Clonazepam 4-8 mg Valproic acid 250-500 mg Oxcarbazepine 1200mg/day
  • 23. Other methods used are • Trichloro ethylene inhalation • Topical capsaicin cream application • Proparacaine 0.5% anaesthetic drops in eye • Anti inflammatory drug-Indomethacin & short courses of steroids are found useful in some cases