Trigeminal neuralgia or TN is inflammation of trigeminal or 5th nerve, one of the most widely distributed nerves in the head. It is a type of neuropathic pain which causes intense facial pain. Trigeminal neuralgia is also known as tic douloureux.
Trigeminal Neuralgia is a condition that occurs on the trigeminal nerve which is the 5th cranial nerve.
The patient experiences a paroxysmal, sharp pain which may arise by certain stimuli.
These involve touching a certain area, shaving, smiling, etc.
Trigeminal Neuralgia is a condition that occurs on the trigeminal nerve which is the 5th cranial nerve.
The patient experiences a paroxysmal, sharp pain which may arise by certain stimuli.
These involve touching a certain area, shaving, smiling, etc.
Trigeminal neuralgia is a truly agonizing condition, in which the patient may clutch the hand over the face and experience severe, laneinating pain associated with spasmodie contractions of the facial muscles during attacks afeature that led to the use of the term (its archaie name ) “Tie Douloureux” (Painful jerking).
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Trigeminal neuralgia is a truly agonizing condition, in which the patient may clutch the hand over the face and experience severe, laneinating pain associated with spasmodie contractions of the facial muscles during attacks afeature that led to the use of the term (its archaie name ) “Tie Douloureux” (Painful jerking).
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This is a PPT of Trigeminal neuralgia for Masters students . take an idea from it...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
Trigeminal Neuralgia
A neuropathic pain caused when trigger site stimulated by brushing, tilting head and shaving, stress and tiredness, cold and hot water, chewing and swallowing, touching and washing face, light breeze or wind on face etc.
The disease is mostly unilateral and can be treated by medications like Carbazepine, oxycarbamazepine, lamotrigine and phenytoin and gabapentin and surgeries like periferal injection, Glycerol injection in the gasserian Ganglion, periferal neurectomy, Cryotherapy, open or intracranial procedures Gammaknife radiosurgeries.
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Facial pain is pain felt in any part of the face, including the mouth and eyes.
It’s normally due to an injury or a headache, occasionally facial pain may also be due to neurological or vascular causes, but equally well may be dental in origin.
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
2. What is Trigeminal Neuralgia
Tic douloureux, which is also termed as trigeminal neuralgia is
an intense stabbing pain to one side of the face. It appears from
one or more branches of the trigeminal nerve that supplies
sensation to the face. The pain caused by Tic Douloureux lasts
from a few seconds to a few minutes. It may be so severe that
you will be compelled to wince involuntarily, that is why the
term tic. Usually the individual neither faces any pain between
attacks nor dysfunction of the muscle of the face.
3.
4. Causes of Tic Douloureux
The cause of tic douloureux is still not known. There are a
number of theories to explain why trigeminal nerve gets
affected. The most widely accepted theory is the compression
of the trigeminal nerve, usually by a blood vessel, causing it to
become inflamated. Due to this irritation the myelin sheath or
the outer covering of the nerve starts eroding over time. The
irritated nerve then becomes more volatile and randomly
instigates pain impulses. Tumors and bony abnormalities of the
skull may press on and irritate trigeminal nerve.
5. Symptoms of Trigeminal Neuralgia
Symptoms of trigeminal neuralgia include an acute onset of
sharp, stabbing pain to one side of the face. It tends to begin at
the angle of the jaw and radiate along the junction lines;
between the ophthalmic branchV1 and maxillary branch V2, or
the maxillary branch V2 and the mandibular branch V3.
The pain is severe and described as an electric shock. It may be
made worse by light touch, chewing, or cold exposure in the
mouth.
6. How is Trigeminal Neuralgia
Diagnosed?
Paroxysmal attacks of pain lasting from a fraction of a second to 2
minutes, affecting 1 or more divisions of the trigeminal nerve and
fulfilling criteria B and C.
Pain has at least one of the following characteristics: (1) intense,
sharp, superficial or stabbing; or (2) precipitated from trigger areas
or by trigger factors
Attacks stereotyped in the individual patient
No clinically evident neurologic deficit
Not attributed to another disorder
7. Treatment for Trigeminal
Neuralgia
Surgical Evaluation for Trigeminal Neuralgia
Microvascular Decompression for Trigeminal Neuralgia
Medical Therapy for Trigeminal Neuralgia
Radiosurgery for Trigeminal Neuralgia
Radiofrequency Lesioning (RFL) for Trigeminal Neuralgia
Clinical Trials for Trigeminal Neuralgia
8. For More Detail & Consultation
Please Visit
www.cnsneurosurgery.com.au