This document discusses several major trade routes between 500-1500 CE, including the Silk Roads, Indian Ocean trade routes, and Trans-Saharan trade routes. It notes that trade along these routes led to the spread of religions, languages, technologies, and diseases across large regions. Specifically, it mentions the diffusion of Buddhism, Christianity, Islam, the Bubonic Plague, and smallpox. Additionally, the document outlines some continuities in long-distance trade over this time period, such as the role of cities and ports as trade hubs and the importance of luxury goods in driving commercial exchange.