This document provides guidance on gut decontamination methods for poisoned patients, including ipecac, gastric lavage, activated charcoal, and whole bowel irrigation. It recommends that ipecac and gastric lavage should rarely be used. Activated charcoal is most effective if administered within one hour of ingestion for known poisons that can be bound by charcoal. Whole bowel irrigation may be useful for sustained-release preparations or potentially toxic heavy metal ingestions if started within 4 hours. Each method has specific guidelines around dosage, timing, and contraindications.