Topical medications are applied directly to body surfaces like the skin, eyes, ears, nose, and rectum. There are many classes of topical medications including creams, ointments, patches, and sprays. The administration of topical medications requires following safety procedures like wearing gloves, applying the correct dose to the right site, and educating the patient. Special considerations are needed for administering eye drops, ointments, and ear drops to ensure the safe and proper application of these topical medications.