Topical Gel for Osteoarthritis

1. Mobiease TG
ULTIMATE EASY MOBILITY

2. Osteoarthritis
 Osteoarthritis is a non-inflammatory,
degenerative condition of joints
Characterized by degeneration of
articular cartilage and formation of new
bone i.e. osteophytes.

3. Osteoarthritis
 Common in weight-bearing joints such
as hip and knee.
 Also seen in spine and hands.
 Both male and females are affected.
 But more common in older women i.e.
above 50 yrs,particularly in
postmenopausal age.

4. Classification of joints

5. Types of joints
Immoveable
Joints connected by
fibrous tissue are
immoveable
e.g. sutures of the skull
Slightly moveable
Joints connected by
cartilage are slightly
moveable
e.g. vertebrae
Freely moveable
Joints separated by a
cavity containing
synovial fluid are freely
moveable
e.g. hip, knee, elbow
Musculoskeletal
diseases generally
affect freely moveable
or synovial joints

6. Synovium
Secretes the
synovial fluid
Capsule
Ligaments hold the
bones together
Synovial fluid
Lubricates the
joint capsule
Bone
Cartilage
Protects the
end of the bone
Anatomy of a freely moveable
(synovial) joint
Muscle
Tendon

7. Types of cartilage
Fibrous
Found where a
tendon or relatively
inelastic ligament
attaches to bone
Elastic
Found in the
earlobes and
supports the
windpipe
Articular
Found on the ends of
bone joints to reduce
friction and act as a
shock absorber
Musculoskeletal
diseases generally
affect articular
cartilage in synovial
joints

8. Cartilage and Fluid Function:-
Reduce friction between bones
Lubricates joints
Fluid provides nutrients to cartilage
Lessens shock of walking and jogging
impact

9. Bone & Soft Tissues Diseases
A – Chronic Inflammatory
Conditions

10. Arthritis (Joints inflammation)
 Arthritis: is a group of conditions involving
damage to the joints of the body with
inflammation
 Major complains: joint pain, inflammation,
tear of joint (edema), muscle strains, stiffness
& fatigue
 Causes:
-Primary forms of arthritis: Osteoarthritis
,Rheumatoid arthritis
-Secondary forms of arthritis: due to other
diseases (eg: Psoriatic arthritis, Reactive

11. Osteoarthritis

14. It is a chronic disorder characterized by softening and
disintegration of articular cartilage, with new growth
of cartilage and bone (osteophytes) at the joint
margins.
OSTEOARTHRITIS (OA)

16. Classification:
i. Primary generalized osteoarthritis (often
hereditary).
ii. Secondary osteoarthritis (secondary to trauma or
previous joint disease).
OSTEOARTHRITIS (OA)

17. 1. Aging
2. Sex
3. Heredity
4. Previous joint disease
5. Climatic factors.
6. Dietetic factors.
7. Trauma to joints
ETIOLOGY OF OSTEOARTHRITIS

18. N.B)Trauma to joints:
Acute trauma: Previous fracture or dislocation
involving joints.
Chronic strain: Accumulated micro traumas &
obesity (excessive body weight obviously
increases the load born by weight - bearing
joints).

19. 1) Pain: varies from mild to very severe
2) Stiffness.
3) Swelling: Synovial swelling of effusion.
4) Limitation of movement.
5) Deformity: results from irregularities of articular
surfaces of large joints.
SYMPTOMS OF OSTEOARTHRITIS

20. I. Cells
Produce fibers and ground substance.
Fibrocytes
1- Condrocytes 2- Octeocytes
Produce cartilage Produce bone
II. Fibers
Protein in nature, collagenous or Elastic or reticular.
III. Ground substance
Protein sugar complexes (Proteoglycans).

21. Modest, patchy
chronic synovitis
Bone ends thicken
Bony outgrowths
(osteophytes) form
Bone fragments may
float in the joint space
Fluid filled cysts may form
in the bone
OA jointNormal joint
Cartilage:
Pitted and frayed surface
Loss of elasticity
Cartilage may wear away
completely
Thickening
of capsule
Characteristics of OA
Dieppe P. 1998

22. Osteoarthritis (OA)... Degenerative Joint Disease
 Osteoarthritis (OA): is a group of mechanical
abnormalities involving degradation of joints including
articular cartilage and subchondral bone
 Symptoms:
Joint pain, tenderness, stiffness, locking, and edema
 Causes:
- Mechanical injury, overweight, loss of strength in
muscles supporting joints, and impairment of
peripheral nerves (leading to sudden or
uncoordinated movements that overstress joints)

23. Risk factors for primary OA
OA
Obesity
Occupation
Age
Family history
Genetics
Trauma
Joint
dysplasia
Bone injury
Gender
Joint injury

24. Rheumatoid arthritis

25. RA is an inflammatory disease
 Most common cause of inflammatory arthritis,
affecting 0.3–1.0% of the population worldwide
 Prevalence increases with age and about twice as
many women are affected as men
 Characterized by lymphoid infiltration of the synovium
leading to joint destruction
 Auto-immune disease
 affecting joints causing a symmetrical polyarthritis
 widespread systemic effects on blood, lungs, eyes
etc.
 Associated with high disability, mortality and morbidity

26. Joint affected by RA
Cartilage damaged and
may be destroyed
Erosions in bone
Swollen inflamed
synovium

27. Rheumatoid Arthritis (RA)
 Rheumatoid arthritis (RA): is a chronic, systemic
inflammatory disorder that may affect many tissues
and organs, but principally attacks synovial joints
 The pathology of the disease process often leads to
the destruction of articular cartilage and ankylosis of
the joints
 Symptoms: include joint pain, tenderness, stiffness,
locking, and sometimes an effusion.

28. Differential diagnosis of OA
from RA
OA RA
More common in
hip and knee
More common in
wrist, elbow and shoulder
Joint tenderness
but no warmth
Joint warmth and redness
Patient typically >45 years
at onset
Usually symmetrical
joint involvement
Patient typically 25–55
years at onset
Asymmetrical joints
Joint space narrowing

30. ingredients
 N-Acetyl-D-Glucosamine
Sulfate (NAG)
 Chondroitin sulfate
 MSM
 Hyaluronic acid
 Clove oil
 Eucalyptus oil
 Gingko Biloba
 Gota Kola
 Menthol
 Camphor
 VitC
 VitC Acetate
 Glycine

31.  Glucosamine is a monosaccharide (2-
amino-2-deoxy-D-glucose; C6H14NO5)
with a high molecular weight .
 It is naturally produced in the human body
and is an important precursor in the
biosynthesis of glycosylated proteins and
lipids.
 Glucosamine is synthesized in vivo from
glucose and is used to produce
glycosaminoglycan chains from which
proteoglycans are formed.
Glucosamine

32. • Fight inflammation,
• Play an important role in lubricating the joints,
• Increasing joint mobility
• slowing or preventing the deterioration of joint
cartilage.
• Relief of joint pain and improvement of symptoms.
Glucosamine

33. Glucosamine

34. Chondroitin
 Chondroitin is a high molecular weight (10 000
– 50 000 Da) glycosaminoglycan, which is found
in cartilage and connective tissue.
 Chondroitin, like glucosamine, is hydrophilic
and soluble in water, producing a viscous fluid
similar to sodium hyaluronate.
 Chondroitin helps maintain the viscosityin
joints, stimulates cartilage repair and inhibits
enzymes that degrade cartilage.

35. Chondroitin

36. Chondroitin:
• Stimulation of the synthesis of proteoglycans and
hyaluronic acid
• Has powerful anti-inflammatory effect.
• Decrease in catabolic activity of chondrocytes
inhibiting the synthesis of proteolytic enzymes, nitric
oxide, and other substances that contribute to
damage cartilage matrix and cause death of
articular chondrocytes.

37. Methyl sulfonyl methane or MSM
• MSM has been proven to have anti-inflammatory and
antioxidant mechanisms in an in-vitro study in which
human neutrophils were artificially stimulated to
produce oxidative compounds, including hydrogen
peroxide, superoxide, and hypochlorous acid. After cell
lines were treated with DMSO2 these free radical by-
products were decreased.

38. • Acting as an anti-inflammatory agent, reduction
in tissue swelling, reduction in vasodilation,
pain is reduced.
• MSM may reduce muscle spasm and MSM
reduces the rate of pain impulse activity in the
C-fiber component of the peripheral nervous
system.

39. Eucalyptus oil
Active constituent
 eucalyptol (1,8-cineol), p-cymene, alpha-pinenes, limonene,
camphene.
Action
 Has Antioxidant Effects.
 has a warming effect on the skin and muscles.
 Helps in getting relief from the pain.
 Has analgesic and anti inflammatory in nature.

40. bilobaGingko
 Antioxidant Properties
 stimulate circulation
 Aid for healing of cartilage and joint.

41. Gotu Kola (Centella)
• Enhance the formulation of tough, fibrous protein
known as collagen in bones, cartilage and
connective tissue.
• These substances work to promote healthy blood
vessels by strengthening their walls and
improving blood flow so improve circulation.
• Antioxidant capacity.
• Anti-inflammatory effect through

42. Clove Oil
 Is used as a topical application to relieve
pain , natural analgesic . antioxidant and
anesthetics properties.
 Clove essential oil possesses anti
inflammatory,
 inhibitory effects of clove on pro-
inflammatory cytokines production by
macrophages.
 inhibit macrophages to produce both IL-
1beta and IL-6.

43. Camphor & Menthol
Camphor
 Is a stimulant, rubefacient & antipruritic .
 it becomes ideal for painful areas.
 Provide symptomatic relief for mild to moderate
muscular and joint aches and pains, muscle
cramps, shoulder aches and stiff neck
 For the temporary relief of pain associated with
rheumatism, arthritis, neuralgia, sprains and
strains of joints and muscles.

44. Camphor & Menthol
Camphor
 Its counterirritant action is due to vasoconstriction
which leads to the activation of reflex mechanisms
resulting in improved local circulation.
 When rubbed on the skin, it acts as a rubefacient and
causes localized vasodilatation , which gives feelings
of comfort and warmth.
 it may create a feeling of coolness, and a mild, local
anesthetic effect, which may be followed by
numbness.
 Antioxidant effect.

45. Camphor & Menthol
Menthol
 It has cold or heat sensations as well as its ant
nociceptive and counterirritant properties
 It dilates the blood vessels causing a sensation
of coldness, followed by an analgesic effect.
 increasing the penetration of components
when applied on the skin, to give a faster onset
of action.
 It is utilized to soothe the effects of muscle
soreness, and even joint pain .

46. Glycerin
Moisturizer
The primary use of glycerin for
the skin is as a moisturizer for dry,
rough or scaly skin.
Reduce irritation .
Anti Bruising and Anti-Swelling

47. Vit C & vit C Acetate
Anti-Oxidant effect
 Vitamin C, as a free-radical fighter, helps ward
off many illnesses linked to oxidation,
including arthritis.
 stimulates collagen synthesis,
 Proteoglycan synthesis is increased in
chondrocyte cultures.
 The effect of chondrocyte protection could be
mediated by its antioxidant capacity.

48. Reduce muscle aches
 For a study published in 2006, 18 healthy
men took either a placebo or three grams of
vitamin C in supplement form each day for
two weeks.
 Next, all participants performed 70 elbow
extensions, then continued taking either the
placebo or vitamin C supplements for four
days.
 Study results showed that vitamin C reduced
muscle soreness.
Zainuddin Z, Newton M, Sacco P, Nosaka K. "Effects of massage on delayed-onset muscle
soreness, swelling, and recovery of muscle function." J Athl Train. 2005 40(3):174-80.

50. New
Idea
Be
differe
nt
TG
technique

58. Mobiease TGG Dual-
Action Formula

59. Mobiease TGG Dual-Action
Formula
• Fight inflammation, encourage new cartilage to
be built, and inhibit the production of enzymes
that destroy cartilage
• Play an important role in lubricating the joints,
• Increasing joint mobility and slowing or
preventing the deterioration of joint cartilage.
• Relief of joint pain and improvement of
symptoms.

60. competitors
name composition company price
Myocool 100 gm Glucosamin + chondrotin +
peperment oil + eucalyptus
oil + winter green oil +
camphor
Purex health
care
Myocool 50 gm
Panol cream 50 gm Glucosamin + MSM+
peperment oil + eucalyptus
oil + Rosemary oil + willow
bark +
EPCI / Arrow
pharm
Sulfax cream 60 gm Glucosamin + MSM+
chondrotin + peperment oil
+ eucalyptus oil +
Rosemary oil + willow bark
+
Park Ville
Sulfax gel 60 gm

61. competitors
name composition company price
Relax Massage
gel 50 gm
Glucosamin + MSM+ chondrotin sabaa
Acucort 60 gm Glucosamin + MSM+ chondrotin
+ camphor + Eugenol + Ginko
biloba
Medics
pharma
Urgent Glucosamin + MSM+ chondrotin
+ camphor + Eugenol + sod.
Hayaluronate + salysilic acid
Health pharm
Maxoran Glucosamin + MSM+ chondrotin
+ herbal extract
Health power
pharm
Osteoforte gel
20 gm
Glucosamin + chondrotin +
peperment oil + Horse chest nut
Pemla
pharma

62. name composition company price
Femorex gel 50
gm
Glucosamin + MSM+
chondrotin + camphor +
Eugenol + Ginko biloba
Rand pharm
Gotavex gel Glucosamin + MSM+ +
camphor + eucalyptus+
Ginko biloba + Gota Kola
+ Vit E
Admo pharm

63. Thank you