The document provides information on preparing and submitting a Paracetamol Elixir formulation. It includes the theory behind elixirs, ingredients for the Paracetamol Elixir, procedure for preparation, storage requirements, results of preparing a 20ml sample, and references. The key steps are to dissolve paracetamol in a mixture of alcohol, propylene glycol, glycerin and sorbital solution, then add purified water to a final volume of 10ml. The 20ml sample prepared was submitted in a well closed amber colored container with a label providing the formulation details.

1. To prepare and submit
Paracetamol Elixir I.P.
Experiment No. 4
Presented by Miss Sudipta Roy

2. • Theory :
• Elixirs are clear liquid oral preparation of potent
drugs like (antibiotics , antihistaminics , sedatives
etc ) on unpalatable drugs . They are pleasantly
flavored and usually attractly colored . Paracetamol
elixir have active paracetamol as analgesic (
reducing pain ) and antipyretic ( reducing
temperature in fever ), that can also be used to
releive the system of influenza fever and cold.

3. • Requirements :
• Apparatus : Mortar , Pestle , Beaker
• Chemicals : Paracetamol , Glycerol , Propylene
Glycol , Sorbital Solution 10 %.

4. • Procedure :
Dissolve paracetamol in a mixture of alcohol , Propylene glycol ,
Glycerin , Sorbital Solution 10 %.
Add sufficient amount of purified water to produce the final volume
up to 10 ml.
• Category : Antipyretic and Analgesic
• Storage : Store in a cool and dark place in well closed container
with neat label protected rom sunlight.
• Result : ---------ml of paracetaml elixir I.P. preparation was
submtted in well closed amber colored container with neat label.

5. Formulation Table
Ingredients Quantity Given Quantity Taken
(Factor * Quantity
given )
Factor
Calculation.
Paracetamol
Glycerol
Propylene Glycol
Sorbital Solution
10 %
Ethanol
Flavouring Agent
Coloring Agen
Preservative Agent
Purified Agent
480 mg
10 ml
2 ml
5 ml
2 ml
Q.S.
Q.S.
Q.S.
2*480 =960 mg
2*10=20 ml
2*2=4 ml
2*5=10 ml
2*2=4 ml
Q.S.
Q.S.
Q.S.
Factor =
Required
Quantity/
Quantity given
= 20 ml/ 10 ml
= 2

6. Observation Table
Name of the
Preparation.
Test Specification Observation
Paracetamol Elixir
IP (20 ml )
Description
Color
Volume
Odour
Taste
Translucent
White
100 ml
Odourless
Sweet

7. Labelling
Paracetamol Elixir IP (20 ml )
Ingredients :
Paracetamol - 960 mg
Glycerol - 20 ml
Propylene Glycol - 4 ml
Sorbital Solution 10 % - 10 ml
Ethanol - 4 ml
Flavouring Agent - Q.S.
Coloring Agent - Q.S.
Preservative Agent - Q.S.
Purified Agent - Q.S.
Category : Antipyretic and Analgesic
Direction : As directed by physician.
Storage : Store in airtight container in cool temperature not exceeding 25 degree
centrigrade.
ManufacturingDate -
Expiry Date -
Manufacturedby-
Manufacturing Place - Depatment of Pharmaceutics , East POint College of Pharmacy,
Janaprabha, Bidarahalli.

8. • Reference :
• A practical book of Pharmaceutics, Rahul B. Lovhare,
Akash Jain , Dr. Md. Rageeb Md. Usman, Nikam
Manohar Baburao, Page No. 11-12
• Text Book :
• Dispensing Pharmacy, Cooper-gun.
• Dispensing Pharmacy , RM Mehta.
• Dispensing Pharmacy, A Practical Manual, Sanmathi B S,
Kalpesh K Mehta, Anshu Gupta