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Pseudo stratified
• False stratified appearance
• All cells resting on a basement membrane
  but not all of them reach the surface
  ( columnar & basal cell)
• Nuclei are at variable level
• No nuclei in the apical 1/3 of the
  cytoplasm
• Associated with cilia & goblet cells
Transitional epithelium
• Specialized epithelium
• Urothelium
• It can stretch greatly without losing its
  integrity
• Undistended
• Distended
UNDISTENDED L/M
• 5 -6 LAYERS
• BASAL LOW COLUMNAR CELLS
• MIDDLE LAYER POLYHEDRAL & FLASK
  SHAPE CELLS
• UPPER LAYER LARGE DOME SHAPE CELLS
         bulge into lumen
         dark pink line
          mono/binucleate
          indentations on under surface
Distended L/M
• 2-3 layer
• Basal low cuboidal
• Surface cells approach a squamous form
CHARACTERISTICS
•   UNILAMINR
•   MITOTIC ACTIVITY
•   IMPERMEABLE
•   STRETCHING
ELECTRON MICROSCPE
• All cells reach basal lamina through
  slender processes
• Outer lipid layer Thick integral proteins
  – Plaques Uroplakin
  – Interplaque areas hinges
• Concentration of microfilament
  – Internalization of membrane vesicle
• Desmosomes between adjacent cells
CHARACTERISTICS
• UNILAMINR MITOTIC ACTIVITY
  – All cells reach basal lamina through slender
    processes
• IMPERMEABLE
  – Thicker outer layer of cell membrane
  – desmosomes
• Ability to change surface area
  – Mucosal folding
  – Dome cells
GLANDULAR EPITHELIUM
• UNICELLULAR
• MULTICELLULAR
  ENDOCRINE aggregated cells form
  anastomosing cordswith interspersed capillaries
  EXOCRINE
        Architectural classification
        mode of secretion
        Type of secretion
Architectural
• Simple
  tubular
       straight large intestine
       coiled----sweat glands
       branched---cardiac end of stomach
  alveolar
        straight----urethra
         branched-----pyloric part of stomach
• Compound
     tubular-----Brunner gland
     alveolar----excretory part
     tubuloalveolar---submandibular
MODE OF SECRETION
• APOCRINE
     apical part of cell is lost with secretion
  modified sweat gland
• MEROCRINE
     no part of cytoplasm is lost e.g. sweat
  gland
• HOLOCRINE
     whole of the cell is lost e.g. sebaceous
  gland
TYPE OF SECRETION
          SEROUS & MUCOUS
•   Bluish purple             • Pink
•   Nucleus round basal       • Flat perpiheral
•   Cell out line not clear
•   Lumen indistinct          • Clear
•   Basal basophilia
                              • Distinct
                              • No basal basophilia
Tissue part 3
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Tissue part 3

  • 1. Pseudo stratified • False stratified appearance • All cells resting on a basement membrane but not all of them reach the surface ( columnar & basal cell) • Nuclei are at variable level • No nuclei in the apical 1/3 of the cytoplasm • Associated with cilia & goblet cells
  • 2.
  • 3. Transitional epithelium • Specialized epithelium • Urothelium • It can stretch greatly without losing its integrity • Undistended • Distended
  • 4. UNDISTENDED L/M • 5 -6 LAYERS • BASAL LOW COLUMNAR CELLS • MIDDLE LAYER POLYHEDRAL & FLASK SHAPE CELLS • UPPER LAYER LARGE DOME SHAPE CELLS bulge into lumen dark pink line mono/binucleate indentations on under surface
  • 5.
  • 6. Distended L/M • 2-3 layer • Basal low cuboidal • Surface cells approach a squamous form
  • 7. CHARACTERISTICS • UNILAMINR • MITOTIC ACTIVITY • IMPERMEABLE • STRETCHING
  • 8. ELECTRON MICROSCPE • All cells reach basal lamina through slender processes • Outer lipid layer Thick integral proteins – Plaques Uroplakin – Interplaque areas hinges • Concentration of microfilament – Internalization of membrane vesicle • Desmosomes between adjacent cells
  • 9. CHARACTERISTICS • UNILAMINR MITOTIC ACTIVITY – All cells reach basal lamina through slender processes • IMPERMEABLE – Thicker outer layer of cell membrane – desmosomes • Ability to change surface area – Mucosal folding – Dome cells
  • 10.
  • 11. GLANDULAR EPITHELIUM • UNICELLULAR • MULTICELLULAR ENDOCRINE aggregated cells form anastomosing cordswith interspersed capillaries EXOCRINE Architectural classification mode of secretion Type of secretion
  • 12.
  • 14. • Simple tubular straight large intestine coiled----sweat glands branched---cardiac end of stomach alveolar straight----urethra branched-----pyloric part of stomach • Compound tubular-----Brunner gland alveolar----excretory part tubuloalveolar---submandibular
  • 15. MODE OF SECRETION • APOCRINE apical part of cell is lost with secretion modified sweat gland • MEROCRINE no part of cytoplasm is lost e.g. sweat gland • HOLOCRINE whole of the cell is lost e.g. sebaceous gland
  • 16.
  • 17. TYPE OF SECRETION SEROUS & MUCOUS • Bluish purple • Pink • Nucleus round basal • Flat perpiheral • Cell out line not clear • Lumen indistinct • Clear • Basal basophilia • Distinct • No basal basophilia