The document discusses Thermo Scientific's leadership in serving science through analytical instruments, equipment, reagents, software and services. It highlights the company's size and scale, unmatched capabilities, portfolio of leading brands, and mission to make the world healthier, cleaner and safer. Key strengths include global industry leadership, ability to continuously invest in growth opportunities through R&D, and an excellent track record of financial performance. New products are presented for applications such as sample preparation, analysis, and data interpretation.
Alyante is a custom research services organisation that delivers quality research to help improve your research efficiencies. It provides comprehensive end-to-end solutions ranging from chemical and pharmaceutical development to product supply, including complete regulatory support for filing. To enhance your product portfolio, Alyante offers innovative services including NDDS.
Alyante’s array of innovation-based services and commitment to excellence will help you create new value.
Alyante is an assurance of an alliance that strives to keep your research always ahead of the competition through innovation and trust.
DCN Diagnostics. Design and Development of Lateral Flow Assay SystemsBrendan O'Farrell
DCN Diagnostics designs and develops rapid assay systems for medical and veterinary diagnostics, bio-defense, agriculture, environmental testing and other market segments. DCN's service offering includes contract assay development, education and training courses in lateral flow technologies, industrial design and mechanical engineering services related to development of related devices for rapid diagnostics. Our specialties include lateral flow, flow through and microfluidic assay formats, and we have developed qualitative, quantitative, visual or fluorescent assay systems. DCN's ISO 9001:228 and EN 13485 compliant quality system is set up to allow us to deliver the full FDA compliant design history file. Our process and unique teams of highly experienced development scientists working alongside our engineering teams allow us to deliver the product, not just the parts. DCN Diagnostics is the sole supplier of cellulose nanobead technology for lateral flow diagnostics outside of Japan and can supply technical consulting and development assistance to companies wishing to develop and manufacture highly sensitive and quantitative lateral flow assays using the NanoAct (tm) beads. Our experience in multiplexing and joint ownership in the Symbolics patents covering aspects of multipex arraying in lateral flow formats allows DCN to assist our clients in creating highly unique and functional assays for any environment or application. DCN also provides our unique UltraGold (tm) colloidal gold for use in lateral flow assays. DCN's 40nm gold colloid is highly controlled, very stable and designed specifically for use in lateral flow and flow through assays.
Established in 1962 Chem Service is the largest independent supplier of Analytical Reference Materials and the original source of small quantities of organic chemicals. Chem Service also has over 2,000 Pesticide Standards, including Pesticide Standards for Cannabis in its catalogue. Chem Service offers Custom made Standards manufactured to your specific requirements, all standards are accredited to ISO 17043:2016; ISO/IEC 17025:2005; ISO 9001:2015 Quality Management System.
Over 95% of Chem Services’ neat Standards Grade materials have a purity of 98.0% or greater.
Chem Services’ worldwide customers are found in the chemical, government, food quality, agricultural and life science research communities.
3 Ways the New Thermo Scientific LC MS Triple Quads Improve Residue AnalysisThermo Fisher Scientific
Learn how the new Thermo Scientific LC-MS triple quadrupole mass spectrometers incorporate unique design features that improve analysis of food matrices for veterinary drug and pesticide residues.
The Thermo Fisher Scientific MicrobeBridge™ software is a desktop application which
connects .ab1 data files generated on Applied Biosystems™ 3500 and 3130 Genetic
Analyzers and 3730 DNA Analyzers with the Centers for Disease Control and
Prevention (CDC)’s MicrobeNet virtual reference database via internet connection for
bacterial identification using 16S rRNA gene sequencing analysis.
High-throughput proteomics: from understanding data to predicting themMaté Ongenaert
High-throughput proteomics: from understanding data to predicting themprof. dr. Lennart Martens
UGent - Department of Biochemistry, Faculty of Medicine and Health Sciences, VIB - Group Leader Computational Omics and Systems Biology Group (CompOmics), Department of Medical Protein Research
In proteomics, as in any high-throughput omics field, the rate of data generation has increased dramatically, yielding very large datasets that require substantial processing to render them useful and interpretable. Key concepts here are data management, data-bound analysis algorithms, and user interface design. But we do not need to limit ourselves to only the interpretation of experimental results. By combining data from across many (unrelated) experiments, we can gain substantial knowledge about the strengths and limitations of our technological approaches. High-throughput methods however, rarely serve as the endpoint for research. As exquisite parallel hypothesis testers, these approaches can quickly highlight promising follow-up targets for more detailed study. Yet moving from discovery to targeted analysis requires much more in-depth understanding of sample and methodology, which is where the insights gained from large-scale data analysis come into play. Armed with this knowledge, we can begin to predict experimental outcomes based on specific hypotheses, thus effectively creating tests or assays that can be used in focused validation experiments
Visualization Approaches for Biomedical Omics Data: Putting It All TogetherNils Gehlenborg
Keynote Talk presented at the 1st Annual BiVi Community Annual Meeting (17 December 2014)
http://bivi.co/page/bivi-annual-meeting-16-17th-december-2014
Visualization Approaches for Biomedical Omics Data: Putting It All Together
The rapid proliferation of high quality, low cost genome-wide measurement technologies such as whole-genome and transcriptome sequencing, as well as advances in epigenomics and proteomics, are enabling researchers to perform studies that generate heterogeneous datasets for cohorts of thousands of individuals. A common feature of these studies is that a collection of genome-wide, molecular data types and phenotypic or clinical characterizations are available for each individual. These data can be used to identify the molecular basis of diseases and to characterize and describe the variations that are relevant for improved diagnosis, prognosis and targeted treatment of patients. An example for a study in which this approach has been successfully applied is The Cancer Genome Atlas project (http://cancergenome.nih.gov).
In my talk I will discuss how visualization approaches can be applied to enable exploration and support analysis of data generated by such studies. Specifically, I will review techniques and tools for visual exploration of individual omics data types, their ability to scale to large numbers of individuals or samples, and emerging techniques that integrate multiple omics data types for interactive visual analysis. I will also examine technical and legal challenges that developers of such visualization tools are facing. To conclude my talk, I will outline research opportunities for the biological data visualization community that address major challenges in this domain.
DNA sequencing: rapid improvements and their implicationsJeffrey Funk
these slides analyze the rapid improvements in DNA sequencers and the implications for these rapid improvements for drug discovery, new crops, materials creation, and new bio-fuels. Many of the rapid improvements are from "reductions in scale." As with integrated circuits, reducing the size of features on DNA sequencers has enabled many orders of magnitude improvements in them. Unlike integrated circuits, the improvements are also due to changes in technology. For example, changes from pyrosequencing to semiconductor and nanopore sequencing have also been needed to achieve the reductions in scale. Second, pyrosequencing also benefited from improvements in lasers and camera chips.
Alyante is a custom research services organisation that delivers quality research to help improve your research efficiencies. It provides comprehensive end-to-end solutions ranging from chemical and pharmaceutical development to product supply, including complete regulatory support for filing. To enhance your product portfolio, Alyante offers innovative services including NDDS.
Alyante’s array of innovation-based services and commitment to excellence will help you create new value.
Alyante is an assurance of an alliance that strives to keep your research always ahead of the competition through innovation and trust.
DCN Diagnostics. Design and Development of Lateral Flow Assay SystemsBrendan O'Farrell
DCN Diagnostics designs and develops rapid assay systems for medical and veterinary diagnostics, bio-defense, agriculture, environmental testing and other market segments. DCN's service offering includes contract assay development, education and training courses in lateral flow technologies, industrial design and mechanical engineering services related to development of related devices for rapid diagnostics. Our specialties include lateral flow, flow through and microfluidic assay formats, and we have developed qualitative, quantitative, visual or fluorescent assay systems. DCN's ISO 9001:228 and EN 13485 compliant quality system is set up to allow us to deliver the full FDA compliant design history file. Our process and unique teams of highly experienced development scientists working alongside our engineering teams allow us to deliver the product, not just the parts. DCN Diagnostics is the sole supplier of cellulose nanobead technology for lateral flow diagnostics outside of Japan and can supply technical consulting and development assistance to companies wishing to develop and manufacture highly sensitive and quantitative lateral flow assays using the NanoAct (tm) beads. Our experience in multiplexing and joint ownership in the Symbolics patents covering aspects of multipex arraying in lateral flow formats allows DCN to assist our clients in creating highly unique and functional assays for any environment or application. DCN also provides our unique UltraGold (tm) colloidal gold for use in lateral flow assays. DCN's 40nm gold colloid is highly controlled, very stable and designed specifically for use in lateral flow and flow through assays.
Established in 1962 Chem Service is the largest independent supplier of Analytical Reference Materials and the original source of small quantities of organic chemicals. Chem Service also has over 2,000 Pesticide Standards, including Pesticide Standards for Cannabis in its catalogue. Chem Service offers Custom made Standards manufactured to your specific requirements, all standards are accredited to ISO 17043:2016; ISO/IEC 17025:2005; ISO 9001:2015 Quality Management System.
Over 95% of Chem Services’ neat Standards Grade materials have a purity of 98.0% or greater.
Chem Services’ worldwide customers are found in the chemical, government, food quality, agricultural and life science research communities.
3 Ways the New Thermo Scientific LC MS Triple Quads Improve Residue AnalysisThermo Fisher Scientific
Learn how the new Thermo Scientific LC-MS triple quadrupole mass spectrometers incorporate unique design features that improve analysis of food matrices for veterinary drug and pesticide residues.
The Thermo Fisher Scientific MicrobeBridge™ software is a desktop application which
connects .ab1 data files generated on Applied Biosystems™ 3500 and 3130 Genetic
Analyzers and 3730 DNA Analyzers with the Centers for Disease Control and
Prevention (CDC)’s MicrobeNet virtual reference database via internet connection for
bacterial identification using 16S rRNA gene sequencing analysis.
High-throughput proteomics: from understanding data to predicting themMaté Ongenaert
High-throughput proteomics: from understanding data to predicting themprof. dr. Lennart Martens
UGent - Department of Biochemistry, Faculty of Medicine and Health Sciences, VIB - Group Leader Computational Omics and Systems Biology Group (CompOmics), Department of Medical Protein Research
In proteomics, as in any high-throughput omics field, the rate of data generation has increased dramatically, yielding very large datasets that require substantial processing to render them useful and interpretable. Key concepts here are data management, data-bound analysis algorithms, and user interface design. But we do not need to limit ourselves to only the interpretation of experimental results. By combining data from across many (unrelated) experiments, we can gain substantial knowledge about the strengths and limitations of our technological approaches. High-throughput methods however, rarely serve as the endpoint for research. As exquisite parallel hypothesis testers, these approaches can quickly highlight promising follow-up targets for more detailed study. Yet moving from discovery to targeted analysis requires much more in-depth understanding of sample and methodology, which is where the insights gained from large-scale data analysis come into play. Armed with this knowledge, we can begin to predict experimental outcomes based on specific hypotheses, thus effectively creating tests or assays that can be used in focused validation experiments
Visualization Approaches for Biomedical Omics Data: Putting It All TogetherNils Gehlenborg
Keynote Talk presented at the 1st Annual BiVi Community Annual Meeting (17 December 2014)
http://bivi.co/page/bivi-annual-meeting-16-17th-december-2014
Visualization Approaches for Biomedical Omics Data: Putting It All Together
The rapid proliferation of high quality, low cost genome-wide measurement technologies such as whole-genome and transcriptome sequencing, as well as advances in epigenomics and proteomics, are enabling researchers to perform studies that generate heterogeneous datasets for cohorts of thousands of individuals. A common feature of these studies is that a collection of genome-wide, molecular data types and phenotypic or clinical characterizations are available for each individual. These data can be used to identify the molecular basis of diseases and to characterize and describe the variations that are relevant for improved diagnosis, prognosis and targeted treatment of patients. An example for a study in which this approach has been successfully applied is The Cancer Genome Atlas project (http://cancergenome.nih.gov).
In my talk I will discuss how visualization approaches can be applied to enable exploration and support analysis of data generated by such studies. Specifically, I will review techniques and tools for visual exploration of individual omics data types, their ability to scale to large numbers of individuals or samples, and emerging techniques that integrate multiple omics data types for interactive visual analysis. I will also examine technical and legal challenges that developers of such visualization tools are facing. To conclude my talk, I will outline research opportunities for the biological data visualization community that address major challenges in this domain.
DNA sequencing: rapid improvements and their implicationsJeffrey Funk
these slides analyze the rapid improvements in DNA sequencers and the implications for these rapid improvements for drug discovery, new crops, materials creation, and new bio-fuels. Many of the rapid improvements are from "reductions in scale." As with integrated circuits, reducing the size of features on DNA sequencers has enabled many orders of magnitude improvements in them. Unlike integrated circuits, the improvements are also due to changes in technology. For example, changes from pyrosequencing to semiconductor and nanopore sequencing have also been needed to achieve the reductions in scale. Second, pyrosequencing also benefited from improvements in lasers and camera chips.
SmashFly Transform: How Storytelling Transformed Thermo Fisher's Employer BrandSmashFly Technologies
This is the way to give an employer brand presentation: by leading with employees and their stories. Charlotte Marshall, Employer Brand Leader at Thermo Fisher Scientific, humanized and personalized the company's employer brand by telling the authentic stories of the people who make the company successful every day.
It was my OB presentation on Thermo Fisher scientific ltd. We have covered journey of Thermo Fisher, Organisation structure, Organisation configuration, Organisation Design, Integrated Model, Relationship with Organizations, Culture etc topics.
The 'omics' revolution: How will it improve our understanding of infections a...WAidid
This slideset explains the ‘Omics’ technology and its role in the study of infections and vaccination. It is a revolution as it offers powerful tools to interrogate the animal / human immune response to vaccines and infections.
Genome size, organization,& gene regulation in prokaryotes (lac-operon)Iqra Wazir
AN overview about genomes, its organization and how it is regulated with reference to lac operon. Important terminologies related to gene regulation. Supported by animation which will run upon downloading.
Employer Brand Integrated Communication Plan (Thermo Fisher)HR Open Source
This template was contributed to by Charlotte Marshall and the Employer Brand team at Thermo Fisher as a resource for their HROS case study, "How Thermo Fisher Used Storytelling To Build Their Employer Brand"
Different omics platforms—genomics, transcriptomics, proteomics, metabolomics and fluxomics—are generating new insights into how biological systems work at a molecular level. Although each individual omics approach provides a global view of a specific cellular process, this view is limited to only one aspect. In order to gain a comprehensive understanding of the system as a whole, researchers are faced with the challenge of merging these different types of results.
PathVisio is an open source tool for drawing and editing biological pathways and visualizing and analyzing data. In order to make multi omics data visualization more intuitive we developed new add ons for the software to enable visualization of multiple data sets that can be about data of different types. This also allows visualization of data on the lines that symbolize interactions and reactions in the pathways, essentially adding edge visualization for network biology. In this way we can for instance show results of fluxomics studies or from dynamic system biology models.
CambridgeIP Fact-based Strategy Development: Accelerating your out-licensingCambridgeIP Ltd
Quentin Tannock (Chairman, CambridgeIP) presented at BIO 2010 in Chicago on the topic 'Fact-based strategy development: Accelerating your out-licensing'. The presentation includes our thoughts on the key directions of innovation in the inhaler device space, together with examples of our work in auto-injectors and other spaces.
Increasing costs and decreased productivity have hampered growth and investment in the global life sciences and health-care sector. The open-innovation approach embraced by many industries could transform the way biotech and health-care companies innovate—bringing products and services to market quickly and efficiently.
What does this mean for business and consumers in Ontario?
Presenting diverse perspectives, this breakfast panel examines the open-innovation approach and identifies opportunities and challenges for health-care stakeholders as they position themselves in the value chain. Learn how to use this approach and leverage it with success.
Currently pi network is not tradable on binance or any other exchange because we are still in the enclosed mainnet.
Right now the only way to sell pi coins is by trading with a verified merchant.
What is a pi merchant?
A pi merchant is someone verified by pi network team and allowed to barter pi coins for goods and services.
Since pi network is not doing any pre-sale The only way exchanges like binance/huobi or crypto whales can get pi is by buying from miners. And a merchant stands in between the exchanges and the miners.
I will leave the telegram contact of my personal pi merchant. I and my friends has traded more than 6000pi coins successfully
Tele-gram
@Pi_vendor_247
how to sell pi coins at high rate quickly.DOT TECH
Where can I sell my pi coins at a high rate.
Pi is not launched yet on any exchange. But one can easily sell his or her pi coins to investors who want to hold pi till mainnet launch.
This means crypto whales want to hold pi. And you can get a good rate for selling pi to them. I will leave the telegram contact of my personal pi vendor below.
A vendor is someone who buys from a miner and resell it to a holder or crypto whale.
Here is the telegram contact of my vendor:
@Pi_vendor_247
Falcon stands out as a top-tier P2P Invoice Discounting platform in India, bridging esteemed blue-chip companies and eager investors. Our goal is to transform the investment landscape in India by establishing a comprehensive destination for borrowers and investors with diverse profiles and needs, all while minimizing risk. What sets Falcon apart is the elimination of intermediaries such as commercial banks and depository institutions, allowing investors to enjoy higher yields.
how can I sell pi coins after successfully completing KYCDOT TECH
Pi coins is not launched yet in any exchange 💱 this means it's not swappable, the current pi displaying on coin market cap is the iou version of pi. And you can learn all about that on my previous post.
RIGHT NOW THE ONLY WAY you can sell pi coins is through verified pi merchants. A pi merchant is someone who buys pi coins and resell them to exchanges and crypto whales. Looking forward to hold massive quantities of pi coins before the mainnet launch.
This is because pi network is not doing any pre-sale or ico offerings, the only way to get my coins is from buying from miners. So a merchant facilitates the transactions between the miners and these exchanges holding pi.
I and my friends has sold more than 6000 pi coins successfully with this method. I will be happy to share the contact of my personal pi merchant. The one i trade with, if you have your own merchant you can trade with them. For those who are new.
Message: @Pi_vendor_247 on telegram.
I wouldn't advise you selling all percentage of the pi coins. Leave at least a before so its a win win during open mainnet. Have a nice day pioneers ♥️
#kyc #mainnet #picoins #pi #sellpi #piwallet
#pinetwork
The European Unemployment Puzzle: implications from population agingGRAPE
We study the link between the evolving age structure of the working population and unemployment. We build a large new Keynesian OLG model with a realistic age structure, labor market frictions, sticky prices, and aggregate shocks. Once calibrated to the European economy, we quantify the extent to which demographic changes over the last three decades have contributed to the decline of the unemployment rate. Our findings yield important implications for the future evolution of unemployment given the anticipated further aging of the working population in Europe. We also quantify the implications for optimal monetary policy: lowering inflation volatility becomes less costly in terms of GDP and unemployment volatility, which hints that optimal monetary policy may be more hawkish in an aging society. Finally, our results also propose a partial reversal of the European-US unemployment puzzle due to the fact that the share of young workers is expected to remain robust in the US.
Seminar: Gender Board Diversity through Ownership NetworksGRAPE
Seminar on gender diversity spillovers through ownership networks at FAME|GRAPE. Presenting novel research. Studies in economics and management using econometrics methods.
The Evolution of Non-Banking Financial Companies (NBFCs) in India: Challenges...beulahfernandes8
Role in Financial System
NBFCs are critical in bridging the financial inclusion gap.
They provide specialized financial services that cater to segments often neglected by traditional banks.
Economic Impact
NBFCs contribute significantly to India's GDP.
They support sectors like micro, small, and medium enterprises (MSMEs), housing finance, and personal loans.
how to sell pi coins in South Korea profitably.DOT TECH
Yes. You can sell your pi network coins in South Korea or any other country, by finding a verified pi merchant
What is a verified pi merchant?
Since pi network is not launched yet on any exchange, the only way you can sell pi coins is by selling to a verified pi merchant, and this is because pi network is not launched yet on any exchange and no pre-sale or ico offerings Is done on pi.
Since there is no pre-sale, the only way exchanges can get pi is by buying from miners. So a pi merchant facilitates these transactions by acting as a bridge for both transactions.
How can i find a pi vendor/merchant?
Well for those who haven't traded with a pi merchant or who don't already have one. I will leave the telegram id of my personal pi merchant who i trade pi with.
Tele gram: @Pi_vendor_247
#pi #sell #nigeria #pinetwork #picoins #sellpi #Nigerian #tradepi #pinetworkcoins #sellmypi
Yes of course, you can easily start mining pi network coin today and sell to legit pi vendors in the United States.
Here the telegram contact of my personal vendor.
@Pi_vendor_247
#pi network #pi coins #legit #passive income
#US
how to sell pi coins on Bitmart crypto exchangeDOT TECH
Yes. Pi network coins can be exchanged but not on bitmart exchange. Because pi network is still in the enclosed mainnet. The only way pioneers are able to trade pi coins is by reselling the pi coins to pi verified merchants.
A verified merchant is someone who buys pi network coins and resell it to exchanges looking forward to hold till mainnet launch.
I will leave the telegram contact of my personal pi merchant to trade with.
@Pi_vendor_247
how to sell pi coins in all Africa Countries.DOT TECH
Yes. You can sell your pi network for other cryptocurrencies like Bitcoin, usdt , Ethereum and other currencies And this is done easily with the help from a pi merchant.
What is a pi merchant ?
Since pi is not launched yet in any exchange. The only way you can sell right now is through merchants.
A verified Pi merchant is someone who buys pi network coins from miners and resell them to investors looking forward to hold massive quantities of pi coins before mainnet launch in 2026.
I will leave the telegram contact of my personal pi merchant to trade with.
@Pi_vendor_247
1. Building on Our Industry
Leadership
The world leader in serving science
Marc N. Casper
Chief Operating Officer
Ian D. Jardine, PhD
Vice President, Global R&D
Pittcon 2009 Press Conference
March 9, 2009
2. The World Leader in Serving Science
We are the leading provider of analytical instruments,
equipment, reagents and consumables, software and services
for research, analysis, discovery and diagnostics.
Leading Brands
Size and Scale Unmatched Capabilities
Complete portfolio
$10.5 billion in revenues
World-class technologies
34,000+ employees in 40 countries
Commercial and service strength
Serving 350,000 customers
in 150 countries
Fortune 300 company
2
3. A Mission We are Proud of
Safer
Healthier Cleaner
We enable our customers to make the world
healthier, cleaner and safer
3
4. Our Strengths
Global industry leadership Ability to continuously invest
in growth opportunities
Key competitive • Developing innovative products
advantages
• Invested $250 million in R&D in 2008
Broad portfolio
• • Strengthening commercial capabilities
Diverse customer base
• • Extending our channel reach
Global reach
• • Expanding in growing markets
Strong balance sheet
• • Focus on China and India
Excellent track record
of financial performance
A partner you can count on
4
5. A Compelling Value Proposition
Targeted
Innovation
We deliver unmatched scientific
productivity through our innovative
technologies, services and systems.
Scientific
Productivity
Extended
Business
Partner
5
6. Thermo Scientific: New Products for Today’s Demands
Better analytical Greater efficiency
Voice of Customer
performance and productivity
Speed and sensitivity Integrated workflows
Precise quantitation Data management
Ease of use Broad applications
Advanced technologies
Laboratory
for non-experts
Industrial and field
Sustainability
Energy efficiency
Reduced solvent usage
Differentiated in performance and productivity
6
7. Fisher Scientific: One Source, Infinite Solutions
Providing customers with a growing portfolio
of convenient sourcing and service options
7
8. Helping our Customers Achieve their Goals
Pharmaceutical Customer
Targeted Laboratory Business
Innovation Productivity Partner
Equipment standardization Consolidated ordering
Scientific collaboration
Methods development Standard operating E-commerce platform
procedures and validation
Application-based Third-party sourcing
workflows Global logistics network Outsourced services
Data management and asset management
8
9. Expanding our Capabilities with Strategic Acquisitions
Equipment
Instrumentation
Chemito Technologies: FiberLite: Carbon fiber centrifuge rotors
Routine analytical instruments
Consumables and Reagents Customer Channels
Open Biosystems: RNAi Hucoa Erloss, Afora, Bonsai:
Affinity Bioreagents: Antibodies Extends European channels
9
11. Pittcon 2009: New Products for Key Applications
Sample Analysis
Sample Preparation
Data Interpretation
11
12. Pittcon 2009: New Products for Sample Preparation
Sample Analysis
Sample Preparation
Data Interpretation
12
13. Pittcon 2009: New Products for Sample Preparation
Hamilton
Distinction II
Green Lab
Meters
Furniture
Hamilton Infinity
Fume Hood
Electrodes
siRNA, shRNA, miRNA
Bioreagents
Protein Catalogs
13
14. Pittcon 2009: New Products for Sample Analysis
Sample Analysis
Sample Preparation
Data Interpretation
14
15. New Thermo Scientific Products for Sample Analysis
Industrial &
Drug Discovery Petroleum &
Environmental &
Basic
Product Testing
& Development Chemical
Food Screening
Research
TSQ Vantage™
LCMS
Access Max™
Transcend TLX™
Accela Exactive™ LCMS
™
NanoDrop
2000/2000c
UV/Vis
Titan 4000™
Niton XRF GOLDD™ NSX Analyzer
R
Arena™
Chemistry Analyzer
A range of innovations, from research to routine testing
15
16. Revolutionary New Micro UV-Vis Capability
Basic Research
Customer Needs: Thermo Scientific NanoDrop
Quick, easy, accurate UV-Vis analysis
Low or no sample prep, reduced solvents
More sensitivity
Our Response:
Unique “all-in-one” Spectrophotometer
Ideal for DNA, RNA, proteins, cell cultures
Patent-pending combination of micro-volume
pedestal and built-in cuvette capability
200X concentration vs. conventional specs
Broad wavelength range
Kinetics capability
Dramatic advances in UV-Vis performance
16
17. Leading-Edge Performance
Thermo Scientific
NanoDrop 2000c
Key Specifications
Broad: concentration range (ng/µl) 0.4 – 15,000 ng/ul (dsDNA)
Broad: wavelength range (nm) 190 - 840
Accurate: absorbance accuracy and precision 2% and .002
Fast: measurement time (secs) <5 (pedestal)
Fast: measurement time (secs) <3 (cuvette)
Versatile: number of path lengths 7
Advanced: custom methods capability yes
Small: minimum sample size (µl) 0.5
Compact: footprint (cm) 14 x 20
17
19. Highest Triple Quad Sensitivity
Drug Discovery & Development
Customer Needs: Thermo Scientific TSQ Vantage Mass Spec
Greater sensitivity (S/N) for
Hesi II probe
ultralow-level quantitation
Precision and reproducibility
Multiple analytes per run
New
Our Response:
sweep
10X more sensitivity than cap
any other triple quad
1,000 SRMs per second and
3,000 timed SRMs per LC run
Full peptide, protein quantitation
TSQ series 2.0.0 software
Patented S-lens
Unmatched signal-to-noise performance exceeds
customer expectations
19
20. TSQ Vantage Beats Existing Systems
Sample Name: quot;Std 0.01quot; Sample ID: quot;quot; File: quot;08305rlc39a PPT Evap 8Mar08 4.wiffquot;
Peak Name: quot;Dextromethorphan-d3quot; Mass(es): quot;275.2/171.2 amuquot;
RT: 0.98 - 3.96
Comment: quot;quot; Annotation: quot;quot;
Sample Index: 31
NL: 1.35E4
RT: 3.04
Sample Type: Standard 2.68
100
Concentration: 0.0100
TIC F: + c ESI
Calculated Conc: 0.0109 740
Acq. Date: 3/9/2008
SRMms2 275.180
Acq. Time: 2:11:48 PM
720
95 [171.049-171.051]
Modified: No
Proc. Algorithm: IntelliQuan - MQII 700
MS ICIS
Noise Percentage: 93
Base. Sub. Window: 1.00 min
680
competitor 90 tt-test_mix_124
Peak-Split. Factor: 2
Report Largest Peak: No
660
Min. Peak Height: 200.00 cps
Min. Peak Width: 4.00 sec
Smoothing Width: 3 points
85
640
RT Window: 30.0 sec
Expected RT: 2.72 min
620
Use Relative RT: No
80
Int. Type: Base To Base 600
Retention Time: 2.69 min
Area: 1892.34 counts
580
Height: 5.72e+002 cps
75
Start Time: 2.63 min
Dextromethorphan-d3
560
End Time: 2.74 min
540
70
In Rat Plasma
520
500
65
(LLOQ at 0.01 ng/mL)
TSQ Vantage
480
460
60
Relative Abundance
440
420
55
>10X LOQ
400
In t e n s it y , c p s
50
380
360
better than
45
340 2.59
3.23
320
40
competitor’s
300
2.82
280 3.07
2.78
35
260 3.41
best efforts
2.85 3.13
2.95 3.58
240 2.40 3.34
30
220
200
25
180
160
20
140
15
120
100
10
80
60
5
40
20
0
0
1.0 1.5 2.0 2.5 3.0 3.5
1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 3.0 3.1 3.2 3.3 3.4 3.5 3.6
Time, min
Time (min)
Unsurpassed triple quad performance
20
21. High Performance for Routine Applications
Environmental & Food Screening
Customer Needs:
Thermo Scientific Workflow Solution
Advanced screening for routine
applications
Higher sensitivity and throughput
Streamlined method development
Our Response:
Simultaneous quantitation and
structural confirmation
Fast +/- switching for high-
speed multi-component trace
analysis
3000 timed SRMs per LC run
New TraceFinder software
Quantum
TraceFinder™ Software
Accela UHPLC Access MAX™
™
The value choice for routine food safety,
pharma, environmental and clinical applications
21
22. Accela-Access Max Performance in Pesticide Screening
Tricyclazole
Carbaryl
Carbofuran
Diuron
Siduron
Daimuron
Carpropamine
Time (minutes)
Complex multi-residue pesticide analysis (10 ppt) in <3 minutes
22
23. End-to-End Workflow for Multiplexing LC/MS/MS
Drug Discovery & Development
Customer Needs:
Thermo Scientific Workflow Solution
In-line sample extraction
End-to-end workflow analysis
Our Response:
Doubles sample analysis
throughput
Increases detection limits
New high performance ultralow
dead volume LC pumps
Fully integrated software for
multiplexed LC-MS
™
Accela UHPLC™ TSQ Vantage
Transcend TLX™
High-throughput benchmark for clinical and drug analysis
23
24. A Revolution in LC-MS
Environmental & Food Screening
Customer Needs:
Thermo Scientific Exactive
Cost effective target ID and
compound identification
Higher throughput analysis with
advanced mass accuracy
Easy-to-use workflow enabler and
productivity platform
Our Response:
Full scan MS with HCD scanning
Walk-up compound identification
• Pesticides, metabolites, tox screening
New quantitation capabilities
Accela UHPLC™
Powerful Pathfinder™ software
Speed, spectra, ultrahigh resolution, superb accurate mass,
and precise quantitation all in an affordable bench-top system
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25. The Value of Reproducible High Mass Accuracy
Total of about 110 pesticides Component Elemental Composition [M+H] Error [ppm]
(each ~ 250 ug/L) Propoxur C11H15NO3 210.1125 1.10
in very complex horse feed matrix Chlortoluron C10H13ClN2O 213.0789 1.20
Metribuzin C8H14N4OS 215.0961 2.00
Atrazine C8H14ClN5 216.1011 2.50
Diuron C9H10Cl2N2O 233.0243 2.00
Carbetamide C12H16N2O3 237.1234 1.20
Pirimicarb C11H18N4O2 239.1503 6.50
Clomazone C12H14ClNO2 240.0786 0.10
Cyanazine C9H13ClN6 241.0963 0.90
Linuron C9H10Cl2N2O2 249.0192 1.20
Thiacloprid C10H9ClN4S 253.0309 0.70
Triadimefon C14H16ClN3O2 294.1004 0.30
Paclobutrazol C15H20ClN3O 294.1368 1.40
Fenthion-
sulfoxide
Fast chromatography (<15mins) C10H15O4PS2 295.0222 2.00
Triadimenol
Exactive running at 15,000 resolution C14H18ClN3O2 296.1161 0.20
Imazalil C14H14Cl2N2O 297.0556 1.70
Spiroxamine C18H35NO2 298.2741 1.20
All molecular weight masses within 2.5 ppm except…
25
26. The Value of Reproducible High Mass Accuracy
Total of about 110 pesticides Component Elemental Composition [M+H] Error [ppm]
(each ~ 250 ug/L) Propoxur C11H15NO3 210.1125 1.10
in very complex horse feed matrix Chlortoluron C10H13ClN2O 213.0789 1.20
Metribuzin C8H14N4OS 215.0961 2.00
Atrazine C8H14ClN5 216.1011 2.50
Diuron C9H10Cl2N2O 233.0243 2.00
Carbetamide C12H16N2O3 237.1234 1.20
6.50
Pirimicarb C11H18N4O2 239.1503 6.50
Clomazone C12H14ClNO2 240.0786 0.10
Pirimicarb
Cyanazine C9H13ClN6 241.0963 0.90
Linuron C9H10Cl2N2O2 249.0192 1.20
Thiacloprid C10H9ClN4S 253.0309 0.70
Triadimefon C14H16ClN3O2 294.1004 0.30
Paclobutrazol C15H20ClN3O 294.1368 1.40
Fenthion-
Unusually high error of 6.5 ppm sulfoxide C10H15O4PS2 295.0222 2.00
Re-analyze @ higher resolution of 80,000 Triadimenol C14H18ClN3O2 296.1161 0.20
Imazalil C14H14Cl2N2O 297.0556 1.70
Spiroxamine C18H35NO2 298.2741 1.20
Only Orbitrap technology allows this level of confidence
26
28. The Value of High Mass Accuracy and
Ultrahigh Resolution
The Case for Exactive
100%
A mixture of >100 pesticides,
Detected compounds ppm
10
250
mycotoxins and veterinary 45%
drugs at different concentration
99%
levels in horse feed matrix
50
analyzed at two resolution 32%
settings utilizing full scan
accurate mass measurements 93%
250
10
(+/- 2ppm)
11%
0 20 40 60 80 100
100k
% Detected
10K
10K resolution can’t detect known chemicals
The power of 100K resolution
Vastly superior analytical results with Orbitrap performance
28
29. The Value of High Mass Accuracy and
Ultrahigh Resolution – Quantitation
Concentration
ranging from
0.2 ppb to 500
ppb
Lowest
Data point
Dextrorphan
profile
with internal
+/- 5 ppm
standard
0.5 - 500 pg
on-column
29
30. New Pathfinder Screening Software for Exactive
Drug Discovery & Development
Thermo Scientific Pathfinder
Enabling the right workflow for
the right user Experienced user
Walk-up user
Developed methods
significantly streamline
analysis
Links into other software:
• Thermo Scientific ToxID
• Thermo Scientific Xcalibur
Reports
Pathfinder leverages full instrument capabilities
30
31. Orbitrap Technology for Routine Screening Applications
Thermo Scientific Exactive
Exactive™ will displace TOFs and QTOFs!
31
32. Superior Total NSX Analysis in a Small Footprint
Petroleum & Chemical
Customer Needs:
Thermo Scientific
Easy sample introduction TITAN 4000 NSX Analyzer
Simple operation
Increased analysis speed and sensitivity
Our Response:
Total nitrogen and total sulfur (TN/TS)
analysis in <2 minutes
Up to 60% reduction in bench space
New nebulizing injection technique with
high efficiency folded combustion tube
NSX visual software EST Analytical
Booth 1816
New capability for QC with increased productivity and lower
operating costs for petrochemical and refinery industries
32
33. Next-Generation Portable XRF Elemental Analysis
Industrial & Product Testing
Customer Needs: Thermo Scientific Niton XL3t GOLDD
Speed and sensitivity
Portable and field rugged
Identify multiple elements
Other Thermo Scientific
Real time data and simple
Technology Niton XL3t GOLDD
software interface
Samples
Our Response:
10x faster than conventional
detectors
3x more precise than traditional
silicon drift detectors Smaller Area
Detector Large Area
Proprietary GOLDDTM Large Area Detector
Drift Detector
Light element detection without
helium or vacuum purging
Breakthrough lab-quality performance in a handheld detector
33
34. “Clinical Chemistry” Analyzer for Non-clinical Labs
Industrial & Product Testing
Customer Needs:
Thermo Scientific Arena Analyzer
Easy and rapid automated methods
Walk-away analysis
Single system for multiple applications
Our Response:
Fast and efficient analysis in an advanced
all-in-one system
• Colorimetric and enzymatic applications
• 45 reagent positions
• Wavelength range 340 to 880 nm
• Automatic barcode ID
Accurate QC and analysis for pharma,
agricultural, food
• Example: Asparagine + glucose = potential
acrylamide formation
Sample throughput up to 600 tests per hour
34
35. Pittcon 2009: New Data Interpretation Solutions
Sample Analysis
Sample Preparation
Data Interpretation
35
36. Pittcon 2009: New Data Interpretation Solutions
Pathfinder TraceFinder
Connects
Enterprise
Insights
OMNIC Specta on Raman
36
37. Pittcon 2009: New Data Interpretation Solutions
0001110101010010010110101001010100101010100011010010101011010101010101010101010101010110101010101010
Maximize customer ROI from previous software investments
37
38. A Mission We are Proud of
Safer
Healthier Cleaner
Environmental &
Food Safety
Pharma & Biotech Industrial
Screening
Quantitation Portability
Confirmation
Speed Speed
Throughput
Selectivity Sensitivity
Ease of use
Data management Robustness
We enable our customers to make the world
healthier, cleaner and safer
38
39. See it All!
Information
Mass Spectrometry Chromatography
Molecular Spectroscopy and Chromatography Consumables
Fisherbrand and Fisher Scientific products Nucleus
LIMS, COS and
Elemental Analysis Chemicals
Spectroscopy
Software
HandheldXRF Analyzers
Mass Spectrometry
and Chromatography
Water Purification Life Science
Discrete Photometric Blue Crew
Analyzers
Sample
Particle Technology Chromatography Preparation
Laboratory Furniture
and Fume Hoods
Elemental Analysis
UV-Visible
Fisherbrand and
Spectroscopy
and Fluorescence Micro/Analytical
Water Analysis Instruments Fisher Scientific products Technologies
TRAM
39
40. Your Passport to Scientific Innovation
Visit Thermo Scientific Booth 1432
Information
Mass Spectrometry Chromatography
Molecular Spectroscopy and Chromatography Consumables
LIMS, COS and
Elemental Analysis
Spectroscopy
Software
HandheldXRF Analyzers
Mass Spectrometry
and Chromatography
Water Purification
Discrete Photometric
Analyzers
Particle Technology
Laboratory Furniture
and Fume Hoods
Elemental Analysis
UV-Visible
and Fluorescence
Water Analysis Instruments
40