The document discusses plasmapheresis, which is a process that involves removing plasma from blood and returning the remaining blood components to the patient. It describes different types of plasmapheresis procedures and their uses, such as removing antibodies, immune complexes, toxins or replacing deficient plasma components. Potential complications are also outlined. The document provides information on both manual and automated plasmapheresis methods and equipment.

1. Dr. Nippun Prinja

2.  Plasmapheresis
 Plasma exchange

3.  TPE
 Healthy Donors Plasma Exchange

4.  Crystalloids
 Colloids
 Plasma Protein Fraction
 FFP

5.  Removal Of Antibodies
 Removal Of Immune Complexes
 Hyperviscosity Syndromes
 Removal Of toxins
 Replacement Of Deficient Plasma
Components

6.  1=standard& acceptable
 2=generally accepted
 3=case studies
 4=lacking efficacy
 P=phase 3 pharma trials

7.  Manual-by use of plastic bag
 Automated-by cell separator machines

8.  Reaction to replacement fluids
 Vasovagal reactions
 Pyrogenic reactions
 Hypocalcemia
 Haemolytic transfusion reactions.

9.  THERAPEUTIC LEUCAPHERESIS
 THERAPEUTIC THROMBOPHERESIS
 THERAPEUTIC ERYTHROPHERESIS

10.  MANUAL
 APHERESIS MACHINE

11.  INTERMITTENT FLOW CENTRIFUGATION.
 CONTINUOUS FLOW CENTRIFUGATION.

12.  Haemonetics
 Density=redcells>white
cells>platelets>plasma
 Seprated components from bowl through
outlet port into seprated bag
 Centrifuge stops and pump get reversed
 Components not required returned to
individual
 6-8 cycles are done till desired quality &
quantity

14.  COMTEC,AMICUS.
 Blood is withdrawn,processed and returned
to the individual simultaneously.
 Earlier two venous access,now one.
 Advantage of speed,small extra corporeal
volume.
 Isovolumeic status of donor is maintained
minimizing fluid loss.

17.  ICU
 Well trained staff
 First aid kit
 Written consent
 Adverse effects/reaction
 Availability of physician if complication